【摘要】：目的觀察308 nm準分子激光聯(lián)合外用5%米諾地爾溶液治療斑禿的療效。方法將102例門診確診的斑禿患者隨機分為兩組,觀察組52例用308 nm準分子激光(每周2次)進行斑禿皮損局部照射,聯(lián)合外涂5%米諾地爾溶液(1 mL/次,2次/d,連用3個月)治療。對照組50例單純外搽5%米諾地爾溶液治療。結(jié)果觀察組有效52例,其中治愈28例(53.85%),顯效17例(33.33%),有效率為87.18%;對照組有效50例,其中治愈16例(32.43%),顯效16例(32.43%),有效率為64.86%。觀察組療效較對照組明顯增高,差異有統(tǒng)計學(xué)意義(P0.05)。與對照組相比,觀察組顯效時間顯著縮短,同時痊愈時間也顯著降低[(41.87±5.63)d vs(72.41±7.82)d,P0.01]。觀察組不良反應(yīng)率較對照組增高(17.95%vs 2.70%,P0.01)。但不良反應(yīng)癥狀表現(xiàn)輕微,不需處理。結(jié)論 308 nm準分子激光聯(lián)合外搽5%米諾地爾溶液治療斑禿相比對照組療效顯著,值得臨床推廣。
[Abstract]:Objective to observe the efficacy of 308th nm excimer laser combined with 5% minodil solution in the treatment of alopecia areata. Methods two hundred and two patients with alopecia areata were randomly divided into two groups. The observation group (n = 52) received local irradiation of alopecia areata skin lesions with 308th nm excimer laser (twice a week) and applied 5% minodil solution (1 mL/ twice a day). The patients were treated for 3 months. In the control group, 50 cases were treated with 5% minodil solution. Results in the observation group, 52 cases were effective, among which 28 cases (53.85%) were cured, 17 cases (33.33%) were obviously effective, and the effective rate was 87.18%. Of the 50 cases in the control group, 16 cases (32.43%) were cured and 16 cases (32.43%) were obviously effective. The effective rate was 64.86%. The therapeutic effect of the observation group was significantly higher than that of the control group, the difference was statistically significant (P0.05). Compared with the control group, the effective time and recovery time in the observation group were significantly shorter than those in the control group [(41.87 鹵5.63) d vs (72.41 鹵7.82) days, P0.01]. The adverse reaction rate in the observation group was higher than that in the control group (17.95%vs 2.70%, P0.01). However, the symptoms of adverse reactions were mild and did not need to be dealt with. Conclusion 308th nm excimer laser combined with external application of 5% minodil solution in the treatment of alopecia areata is more effective than that of the control group, which is worthy of clinical application.
【作者單位】： 廣東省佛山市第一人民醫(yī)院皮膚科;
【分類號】：R758.71

【參考文獻】

相關(guān)期刊論文 前6條

1 張麗榮,王春華,賀艷麗,劉愛華;米諾地爾外用治療脫發(fā)的研究及臨床評價[J];國外醫(yī)藥(合成藥 生化藥 制劑分冊);2000年01期

2 陳聲利,孫建方;米諾地爾治療脫發(fā)的藥理與臨床研究[J];國外醫(yī)學(xué).皮膚性病學(xué)分冊;2004年05期

3 劉琴;楊春俊;張學(xué)軍;楊森;;308nm準分子激光治療斑禿進展[J];國際皮膚性病學(xué)雜志;2006年04期

4 劉愛民;yす，

本文編號：2460591