【摘要】：目的:問卷調(diào)查后分析玫瑰痤瘡發(fā)病的相關(guān)因素;對比奧硝唑、甲硝唑?qū)γ倒屦畀彽闹委熜Ч?探討新的通過殺滅蠕形螨治療玫瑰痤瘡的方法。方法:選定固定診室及醫(yī)生,對2015-10~2016-03間在我科門診進行診斷、治療的253例玫瑰痤瘡患者以問卷方式收集其一般情況、病史及發(fā)病經(jīng)過、生活習慣、加重因素等信息,統(tǒng)計分析玫瑰痤瘡發(fā)病的相關(guān)因素;篩選螨蟲陽性的各型玫瑰痤瘡100例,隨機分為2組,分別采用奧硝唑片、甲硝唑片根據(jù)患者病情治療2~4w,隨訪24w,統(tǒng)計試驗兩組患者螨蟲檢出率、治愈率、總有效率、復發(fā)率,對比奧硝唑與甲硝唑的治療效果。結(jié)果:玫瑰痤瘡患者蠕形螨陽性率為90.51%,誘因或加重因素為日曬(30.83%)、辛辣(30.43%)、化妝品(13.04%)、飲酒(12.65%)、精神緊張(8.70%)、勞累(4.35%)和藥物(0)。隨訪結(jié)束時,奧硝唑治療組螨蟲檢出率為52%,治愈率為30%,總有效率為84%,復發(fā)率為10%;甲硝唑治療組螨蟲檢出率為62%,治愈率為12%,總有效率為50%,復發(fā)率為14%。兩組的治愈率、總有效率差異具有統(tǒng)計學意義(P0.05),螨蟲檢出率、復發(fā)率差異無統(tǒng)計學意義(P0.05)。結(jié)論:玫瑰痤瘡的發(fā)生與日曬、辛辣、化妝品關(guān)系較大;奧硝唑、甲硝唑治療螨蟲陽性的玫瑰痤瘡均有明顯療效,奧硝唑抗蠕形螨治療玫瑰痤瘡效果優(yōu)于甲硝唑。
[Abstract]:Objective: to analyze the related factors of roseacne, to compare the efficacy of ornidazole and metronidazole in the treatment of roseacne, and to explore a new method to treat roseacne by killing Demodex. Methods: a total of 253 patients with roseacne were selected for diagnosis in our department from 2015-10 to 2016-03. The information of general information, history and course of onset, living habits and aggravating factors were collected by questionnaire. The related factors of Acne rosacea were statistically analyzed. 100 cases of rose-acne with positive acariasis were selected and randomly divided into two groups. Ornidazole tablets and metronidazole tablets were treated according to the condition of the patients for 2 weeks and 4 weeks, followed up for 24 weeks. The detection rate, cure rate, total effective rate and recurrence rate of acariasis in the two groups were statistically analyzed. The therapeutic effects of ornidazole and metronidazole were compared. Results: the positive rate of Demodex in rose-acne patients was 90.51.The inducement or aggravating factors were sun (30.83%), spicy (30.43%), cosmetics (13.04%), drinking (12.65%), and stress (8.70%). Fatigue (4.35%) and drugs (0). At the end of follow-up, the detection rate of mite in ornidazole treatment group was 52, the cure rate was 30, the total effective rate was 84 and the recurrence rate was 10. In metronidazole treatment group, the detection rate of mites was 62%, the cure rate was 12, the total effective rate was 50 and the recurrence rate was 14. The difference of cure rate and total effective rate between the two groups was statistically significant (P0.05), but there was no significant difference in the detection rate and recurrence rate of mites (P0.05). Conclusion: the occurrence of rose-acne is closely related to the sun, pungent and cosmetic, ornidazole and metronidazole are effective in treating roseacne with acariasis positive, ornidazole is better than metronidazole in treating rose-acne.
【學位授予單位】：蘭州大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R758.734

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