【摘要】：目的 分析大皰性類天皰瘡的臨床表現(xiàn)、診斷標(biāo)準(zhǔn)、鑒別診斷及輔助檢查特征,提高對該病的認(rèn)識,減少臨床誤診率及漏診率。方法 回顧性分析1例診斷為大皰性類天皰瘡患者的臨床資料,并結(jié)合國內(nèi)外相關(guān)的文獻,對大皰性類天皰瘡特征性臨床表現(xiàn)、診斷、鑒別診斷等進行討論。結(jié)果 患者男性,56歲,全身紅斑、水皰,瘙癢2月余。尼氏征陰性,全身散在分布紅斑,張力性水皰、大皰,部分糜爛,表面血痂。輔助檢查結(jié)果顯示：血常規(guī)：WBC 8.14×109/L, HGB 132g/L, RBC 4.05×1012/L。尿常規(guī)：GLU(3+)組織病理：符合大皰性類天皰瘡。診斷：大皰性類天皰瘡。治療以系統(tǒng)應(yīng)用糖皮質(zhì)激素為主聯(lián)合免疫抑制劑,治療有效。結(jié)論 大皰性類天皰瘡是一種表皮下大皰性皮膚病,常見于老年人,張力性水皰位于正�；蜓装Y性皮膚上,免疫病理學(xué)檢查在表皮基底膜帶有IgG和C3線狀沉積為特點。其需要與天皰瘡、獲得性大皰性表皮松解癥、皰疹樣皮炎和大皰性紅斑狼瘡等疾病鑒別。對于明確大皰性類天皰瘡的患者,要通過臨床癥狀、組織病理學(xué)、免疫學(xué)等各項輔助檢查評估疾病的損害程度,做到早發(fā)現(xiàn)、早診斷、早治療,最大程度降低機體的損傷。
[Abstract]:Objective to analyze the clinical manifestations, diagnostic criteria, differential diagnosis and auxiliary examination features of bullous pemphigoid, to improve the understanding of the disease and to reduce the rate of clinical misdiagnosis and missed diagnosis. Methods the clinical data of a patient with bullous pemphigoid were analyzed retrospectively, and the clinical features, diagnosis and differential diagnosis of bullous pemphigoid were discussed. Results the patient, 56 years old, had erythema, blister and itching for more than 2 months. Nissl's sign negative, the whole body scattered erythema, tension blister, bullous, partial erosion, surface blood scab. The results of auxiliary examination showed that WBC 8.14 脳 109 / L, HGB 132g / L, RBC 4.05 脳 1012 / L, blood routine: WBC 8.14 脳 10 9 / L, HGB 132 g / L, RBC 4.05 脳 10 12 / L. Urine routine: GLU (3) histopathology: in accordance with bullous pemphigoid. Diagnosis: bullous pemphigoid. The therapy is based on the systematic application of glucocorticoid and immunosuppressant. Conclusion bullous pemphigoid is a kind of subepidermal bullous dermatosis, which is common in the elderly. The tensional blister is located on the normal or inflammatory skin, and the immunopathology is characterized by IgG and C3 linear deposition in the epidermal basement membrane. It needs to be distinguished from pemphigus, acquired bullous epidermolysis, herpes dermatitis and bullous lupus erythematosus. For the patients with bullous pemphigoid, the degree of damage should be evaluated by clinical symptoms, histopathology, immunology and other auxiliary examinations, so as to make early detection, early diagnosis, early treatment, and minimize the damage of the body.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：R758.66

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相關(guān)期刊論文 前1條

1 李妍;王娣;陳喜雪;鐘珊;邱于芳;趙俊郁;朱學(xué)駿;;BP180NC16a與大皰性類天皰瘡病情變化的關(guān)系[J];中國皮膚性病學(xué)雜志;2009年06期

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本文編號：2406058