【摘要】：目的:探討手部濕疹的潛在病因及該類患者對日常接觸致敏原的敏感性,并分析其性別、年齡和職業(yè)特點。 方法:研究對象為2008年7月至2009年4月間在廣州醫(yī)學院第二附屬醫(yī)院皮膚科就診的手部慢性濕疹患者共110例,所有入選患者15天內(nèi)未使用過糖皮質(zhì)激素,7天內(nèi)未使用過免疫調(diào)節(jié)劑,3天內(nèi)未服用過抗組胺藥,并排除濕疹處于急性期的患者以及孕婦。應(yīng)用“瑞敏”斑貼試劑盒檢測患者對日常接觸致敏原的敏感性,結(jié)果按陰性、可疑陽性、弱陽性、強陽性、極強陽性、刺激性反應(yīng)分類分級判定。分別按性別、年齡、職業(yè)分組,分析各種過敏原的總體陽性率及在不同組別中的陽性率。采用SPSS 13.0統(tǒng)計軟件,用χ2檢驗分析陽性率差異的顯著性,P0.05為差異有統(tǒng)計學意義。 結(jié)果:受檢的110例患者中有94例(85.5%)斑貼試驗出現(xiàn)陽性反應(yīng),位列前5種最常見的致敏原分別為重鉻酸鉀、硫酸鎳、氯化鈷、芳香混合物和甲醛,男性患者中對苯二胺基質(zhì)、秋蘭姆混合物及黑橡膠混合物的陽性檢出率明顯高于女性。不同年齡段各種致敏原陽性率差異無顯著性意義。從事某些特定職業(yè)的患者(工人、家庭主婦、布匹銷售員等)陽性率明顯較高。 結(jié)論:斑貼試驗有助于明確手部濕疹患者的接觸性致敏原,對提高其治療的針對性,并通過避免或去除致敏原切斷過敏反應(yīng),達到治愈并防止復發(fā)甚至根治的目的,有極其重要的臨床意義。
[Abstract]:Objective: to investigate the potential etiology of hand eczema and its sensitivity to daily exposure allergens, and to analyze its sex, age and occupational characteristics. Methods: from July 2008 to April 2009, 110 patients with chronic eczema of hand were treated in Department of Dermatology, second affiliated Hospital of Guangzhou Medical College, all of whom had not used glucocorticoid in 15 days. No immunomodulators were used in 7 days, no antihistamines were taken in 3 days, and eczema patients and pregnant women were excluded. The sensitivity of the patients to daily contact allergens was determined by using the "Ruimin" patch kit. The results were classified according to negative, suspicious positive, weak positive, strong positive, very strong positive and irritating reaction classification. The total positive rate of each allergen and the positive rate in different groups were analyzed according to sex, age and occupation. Using SPSS 13.0 statistical software, 蠂 2 test was used to analyze the significance of positive rate, P0.05 as the difference was statistically significant. Results: 94 (85.5%) of 110 patients were positive for patch test. The most common allergens were potassium dichromate, nickel sulfate, cobalt chloride, aromatic mixture and formaldehyde. The positive rates of p-phenylenediamine matrix, chylum mixture and black rubber mixture in male patients were significantly higher than those in women. There was no significant difference in the positive rate of allergens between different age groups. The positive rate of patients (workers, housewives, cloth salesmen, etc.) in certain occupations was significantly higher. Conclusion: patch test is helpful to identify contact allergen in patients with hand eczema, to improve the pertinence of treatment, and to cure and prevent recurrence or even radical cure by avoiding or removing allergen. Has extremely important clinical significance.
【學位授予單位】：廣州醫(yī)學院
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R758.2

【參考文獻】

相關(guān)期刊論文 前7條

1 吳大軍;江安世;吳秀華;宿宏;;1%硝酸益康唑與0.1%曲安奈德霜治療皮炎濕疹類皮膚病臨床療效觀察[J];臨床皮膚科雜志;2006年08期

2 谷梅,顧有守;手部慢性濕疹斑貼試驗結(jié)果分析[J];嶺南皮膚性病科雜志;1998年02期

3 曾楚若;楊健;楊文林;黃新宇;王霞;;110例手部濕疹斑貼試驗臨床分析[J];嶺南皮膚性病科雜志;2009年04期

4 黨寧寧,王麗華,吳耀梅,張書華;手部濕疹對生活質(zhì)量的影響及派瑞松對其改善的研究[J];中國麻風皮膚病雜志;2005年03期

5 趙娟;;手部慢性濕疹80例斑貼試驗結(jié)果分析[J];內(nèi)蒙古醫(yī)學雜志;2006年10期

6 杜榮昌,王俠生;手部濕疹363例臨床分析[J];中國皮膚性病學雜志;1999年03期

7 付蘭芹;謝文紅;余夢清;郭穎;杜榮昕;閆倩姝;趙們;梁香翠;王寶璽;李俊其;;530例皮炎濕疹類皮膚病斑貼試驗結(jié)果分析[J];中國預(yù)防醫(yī)學雜志;2006年05期

，

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