【摘要】：目的:探討手部濕疹的潛在病因及該類(lèi)患者對(duì)日常接觸致敏原的敏感性,并分析其性別、年齡和職業(yè)特點(diǎn)。 方法:研究對(duì)象為2008年7月至2009年4月間在廣州醫(yī)學(xué)院第二附屬醫(yī)院皮膚科就診的手部慢性濕疹患者共110例,所有入選患者15天內(nèi)未使用過(guò)糖皮質(zhì)激素,7天內(nèi)未使用過(guò)免疫調(diào)節(jié)劑,3天內(nèi)未服用過(guò)抗組胺藥,并排除濕疹處于急性期的患者以及孕婦。應(yīng)用“瑞敏”斑貼試劑盒檢測(cè)患者對(duì)日常接觸致敏原的敏感性,結(jié)果按陰性、可疑陽(yáng)性、弱陽(yáng)性、強(qiáng)陽(yáng)性、極強(qiáng)陽(yáng)性、刺激性反應(yīng)分類(lèi)分級(jí)判定。分別按性別、年齡、職業(yè)分組,分析各種過(guò)敏原的總體陽(yáng)性率及在不同組別中的陽(yáng)性率。采用SPSS 13.0統(tǒng)計(jì)軟件,用χ2檢驗(yàn)分析陽(yáng)性率差異的顯著性,P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果:受檢的110例患者中有94例(85.5%)斑貼試驗(yàn)出現(xiàn)陽(yáng)性反應(yīng),位列前5種最常見(jiàn)的致敏原分別為重鉻酸鉀、硫酸鎳、氯化鈷、芳香混合物和甲醛,男性患者中對(duì)苯二胺基質(zhì)、秋蘭姆混合物及黑橡膠混合物的陽(yáng)性檢出率明顯高于女性。不同年齡段各種致敏原陽(yáng)性率差異無(wú)顯著性意義。從事某些特定職業(yè)的患者(工人、家庭主婦、布匹銷(xiāo)售員等)陽(yáng)性率明顯較高。 結(jié)論:斑貼試驗(yàn)有助于明確手部濕疹患者的接觸性致敏原,對(duì)提高其治療的針對(duì)性,并通過(guò)避免或去除致敏原切斷過(guò)敏反應(yīng),達(dá)到治愈并防止復(fù)發(fā)甚至根治的目的,有極其重要的臨床意義。
[Abstract]:Objective: to investigate the potential etiology of hand eczema and its sensitivity to daily exposure allergens, and to analyze its sex, age and occupational characteristics. Methods: from July 2008 to April 2009, 110 patients with chronic eczema of hand were treated in Department of Dermatology, second affiliated Hospital of Guangzhou Medical College, all of whom had not used glucocorticoid in 15 days. No immunomodulators were used in 7 days, no antihistamines were taken in 3 days, and eczema patients and pregnant women were excluded. The sensitivity of the patients to daily contact allergens was determined by using the "Ruimin" patch kit. The results were classified according to negative, suspicious positive, weak positive, strong positive, very strong positive and irritating reaction classification. The total positive rate of each allergen and the positive rate in different groups were analyzed according to sex, age and occupation. Using SPSS 13.0 statistical software, 蠂 2 test was used to analyze the significance of positive rate, P0.05 as the difference was statistically significant. Results: 94 (85.5%) of 110 patients were positive for patch test. The most common allergens were potassium dichromate, nickel sulfate, cobalt chloride, aromatic mixture and formaldehyde. The positive rates of p-phenylenediamine matrix, chylum mixture and black rubber mixture in male patients were significantly higher than those in women. There was no significant difference in the positive rate of allergens between different age groups. The positive rate of patients (workers, housewives, cloth salesmen, etc.) in certain occupations was significantly higher. Conclusion: patch test is helpful to identify contact allergen in patients with hand eczema, to improve the pertinence of treatment, and to cure and prevent recurrence or even radical cure by avoiding or removing allergen. Has extremely important clinical significance.
【學(xué)位授予單位】：廣州醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類(lèi)號(hào)】：R758.2

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