【摘要】：目的：觀察蜂房退疣飲聯(lián)合氨基酮戊酸光動力（ALA-PDT)療法治療扁平疣的臨床療效及對患者T細(xì)胞亞群的影響。 方法：將43例扁平疣患者隨機(jī)分成2組，治療組22例，內(nèi)服蜂房退疣飲聯(lián)合ALA-PDT治療；對照組21例，單純應(yīng)用ALA-PDT治療。每周復(fù)診1次，為1療程，皮疹未消退者再行下1療程治療。療程4周，，觀察兩組的臨床療效及不良反應(yīng)，同時觀察比較3個月后兩組復(fù)發(fā)率及治療前后患者T細(xì)胞亞群水平的變化。 結(jié)果：臨床療效：兩組總有效率均為100%；治愈率治療組為90.91%，對照組為85.71%，治療組治愈率略高于對照組，差異無統(tǒng)計學(xué)意義（P0.05）；治療組治療次數(shù)少于對照組，差異有統(tǒng)計學(xué)意義（P0.05）；3個月后隨訪，治療組復(fù)發(fā)率低于對照組，差異有統(tǒng)計學(xué)意義（P0.05）。實驗室檢測：治療前，兩組CD8~+水平均高于正常對照組，CD4~+、CD4~+/CD8~+均低于正常對照組（P0.05）；治療后，治療組CD8~+水平有明顯下降，CD4~+、 CD4~+/CD8~+水平有明顯上升，均有統(tǒng)計學(xué)意義（P0.05）；對照組治療前后血清CD4~+、CD8~+、CD4~+/CD8~+水平未見明顯變化（P㧐0.05）；治療后二組比較，治療組CD8~+水平低于對照組，CD4~+、CD4~+/CD8~+水平高于對照組，差異有統(tǒng)計學(xué)意義（P㩳0.05）。 結(jié)論：蜂房退疣飲聯(lián)合ALA-PDT治療扁平疣的臨床療效確切，可以明顯縮短治療療程，降低復(fù)發(fā)率，其作用機(jī)理可能與調(diào)整體內(nèi)T細(xì)胞亞群水平有關(guān)。
[Abstract]:Objective: to observe the clinical effect and the effect on T cell subsets of patients with verruca plana treated by Bei Fang Tuiyou Yin and Aminolevulinic Acid photodynamic (ALA-PDT). Methods: Forty-three patients with verruca plana were randomly divided into two groups: the treatment group (n = 22), treated with hive verruca decoction and ALA-PDT, and the control group (n = 21, treated with ALA-PDT alone). Return visit once a week for a course of treatment, rash did not subside the next course of treatment. After 4 weeks of treatment, the clinical efficacy and adverse reactions of the two groups were observed, and the changes of the recurrence rate and the T cell subsets before and after treatment in the two groups were observed and compared at the same time. Results: the total effective rate of the two groups was 100. The cure rate was 90.91 in the treatment group and 85.71 in the control group. The cure rate in the treatment group was slightly higher than that in the control group, the difference was not statistically significant (P0.05), the number of times of treatment in the treatment group was less than that in the control group, and the difference was statistically significant (P0.05). After 3 months follow-up, the recurrence rate in the treatment group was lower than that in the control group, the difference was statistically significant (P0.05). Laboratory test: before treatment, the levels of CD8~ in the two groups were higher than those in the normal control group, CD4~, CD4~ / CD8~ were lower than those in the normal control group (P0.05), after treatment, the CD8~ level in the treatment group was significantly decreased, the CD4~, CD4~ / CD8~ levels were significantly increased (P0.05), and the levels of CD4~ and CD4~ / CD8~ in the treatment group were significantly higher than those in the control group (P0.05). The levels of serum CD4~, CD8~, CD4~ / CD8~ in the control group were not significantly changed before and after treatment, and the levels of CD8~, CD4~ and CD4~ / CD8~ in the treatment group were lower than those in the control group (P0. 05). Conclusion: the clinical curative effect of honeycomb Tuiyou decoction combined with ALA-PDT in the treatment of verruca plana is definite, which can shorten the course of treatment and reduce the recurrence rate. The mechanism may be related to adjusting the level of T cell subsets in vivo.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R752.52

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 董玉玲;中藥治療扁平疣40例療效觀察[J];河北醫(yī)學(xué);1998年09期

2 嚴(yán)先瓊;;氟尿嘧啶聚肌胞外涂治療扁平疣療效觀察[J];華西醫(yī)學(xué);2006年02期

3 劉超;;冷凍聯(lián)合藥物治療扁平疣80例療效觀察[J];現(xiàn)代預(yù)防醫(yī)學(xué);2011年04期

4 譚亞平;;四聯(lián)療法治療扁平疣62例的療效觀察[J];重慶醫(yī)學(xué);2008年17期

5 王春釗;;中西醫(yī)結(jié)合治療扁平疣48例[J];中國社區(qū)醫(yī)師(醫(yī)學(xué)專業(yè));2011年18期

6 郭硯;;干擾素局部注射治療扁平疣30例療效觀察[J];青海醫(yī)藥雜志;2008年05期

7 易繼科;;耳針治療扁平疣32例療效觀察[J];中國初級衛(wèi)生保健;1988年05期

8 宋穎R

本文編號：2285236