【摘要】： 目的：在延邊大學(xué)附屬醫(yī)院皮膚科門診就診的小兒特應(yīng)性皮炎(atopic dermatitis, AD)患者,通過觀察血清總IgE水平和過敏原特異性IgE抗體以及過敏原的調(diào)查研究,為預(yù)防和診治延邊地區(qū)小兒AD提供可靠的科學(xué)依據(jù)。 方法：本研究中所用資料均來自2006年3月到2009年3月到延邊大學(xué)附屬醫(yī)院皮膚科門診就診并確定為AD的患者,共200例。分為兩個組,即嬰幼兒組和小兒組,每組100例,每組又按民族分為朝漢兩個小組,每組各50例。同時選擇38例正常體檢小兒為對照組。用敏篩定量過敏原檢測系統(tǒng),定量檢測血清中總IgE和過敏原特異性IgE抗體。所有數(shù)據(jù)均用SPSS.10.0統(tǒng)計學(xué)軟件進行統(tǒng)計學(xué)處理。結(jié)果：(1)在200例被檢患者中,血清總IgE水平超過正常值上線100IU/ml的有114例(57%)。(2)在200例被檢患者中血清特異性IgE陽性111例(55.5%)。(3)在200例被檢患者中血清特異性IgE陽性111例中只對1種過敏原發(fā)生陽性反應(yīng)的有50例(25%),對2種過敏原呈陽性反應(yīng)39例(19.5%),對2種以上過敏原呈陽性反應(yīng)22例(11%)。(4)在200例被檢患者中血清特異性IgE只有吸入組呈陽性反應(yīng)的有43例(21.5%)。(5)在200例被檢患者中血清特異性IgE只有食入組呈陽性反應(yīng)的有46例(23%)。(6)在200例被檢患者中血清特異性IgE吸入、食入組均呈陽性反應(yīng)的有23例(11.5%)。(7)在200例被檢患者中陽性率較高的特異性過敏原依次為牛奶45(22.5%)、牛肉羊肉39(19.5%)、戶塵螨粉塵螨35(17.5%)、魚蝦蟹16(8.0%)。(8)從年齡上看,嬰幼兒組的100例中陽性率較高的特異性過敏原依次為牛奶24(24%),牛肉羊肉20(20%),戶塵螨粉塵螨19(19%),小麥9(9%),小兒組的100例中陽性率較高的特異性過敏原依次為牛奶21(21%),牛肉羊肉19(19%),戶塵螨粉塵螨16(16%),點青霉分枝孢霉煙曲霉交鏈孢霉11(11%)。 結(jié)論：(1)AD患者有IgE合成增加。(2)AD患者為多種抗原過敏。(3)延邊地區(qū)小兒AD患者陽性率較高的特異性過敏原依次為牛奶、牛肉羊肉、戶塵螨粉塵螨、魚蝦蟹。(4)朝鮮族與漢族AD患者總IgE值及特異性IgE檢測,無顯著差異。
[Abstract]:Objective: To investigate the serum total IgE level, allergen specific IgE antibody and allergen in children with atopic dermatitis (AD) in the dermatology outpatient department of Yanbian University Affiliated Hospital, and to provide reliable scientific basis for the prevention and treatment of AD in Yanbian area.
Methods: The data used in this study were from the dermatology outpatient clinic of Yanbian University Affiliated Hospital from March 2006 to March 2009, 200 cases were divided into two groups: infant group and children group, 100 cases in each group, 50 cases in each group according to nationality. All the data were analyzed by SPSS.10.0 statistical software. Results: (1) Among 200 patients, 114 (57%) had serum total IgE levels exceeding 100 IU/ml of the normal value. Of the 200 patients examined, only 50 (25%) had positive reactions to one allergen, 39 (19.5%) had positive reactions to two allergens, and 22 (11%) had positive reactions to more than two allergens. 43 (21.5%) of the inhalation group were positive. (5) Of the 200 patients examined, only 46 (23%) were positive for serum specific IgE in the ingestion group. (6) Serum specific IgE was inhaled in 200 patients and 23 (11.5%) were positive in the ingestion group. (7) Specific allergens with high positive rates were found in 200 patients. Milk 45% (22.5%), beef and mutton 39% (19.5%), house dust mite 35% (17.5%) and fish, shrimp and crab 16% (8.0%). (8) From the age point of view, the specific allergens with higher positive rate in 100 cases of infant group were milk 24% (24%), beef and mutton 20% (20%), house dust mite 19% (19%) and wheat 9% (9%). The allergens were milk 21% (21%), beef and mutton 19% (19%), house dust mite 16% (16%) and Penicillium fumigatus 11% (11%).
Conclusion: (1) AD patients have increased IgE synthesis. (2) AD patients are allergic to a variety of antigens. (3) The higher positive rate of specific allergens in children with AD in Yanbian is milk, beef and mutton, household dust mites, dust mites, fish, shrimp and crabs. (4) There is no significant difference in total IgE value and specific IgE detection between Korean and Han AD patients.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R758.2

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