【摘要】：扁平苔蘚（Lichen planus，LP）為一種臨床常見的慢性或亞急性炎癥性皮膚疾病，但是目前對該病的研究并不充分，特別是對其發(fā)病機制以及在惡化過程中的相關因素研究較少。一般多認為LP為自身免疫性疾病，因此，本研究通過對患者IL-20在患者患病及治療過程中的表達,以確認IL-20這種免疫因子對于LP進展中的影響。 目的：分析扁平苔蘚發(fā)病過程中，IL-20在患者外周血表達水平變化特點，為該病的發(fā)病機理及進展期治療提供有力的支持，從而完善該病的治療體系。同時，為進一步的確定該病的發(fā)病機制提供有力的臨床依據。 方法：回顧性分析本院門診和住院的30例臨床確診為LP的患者的臨床治療情況，其中，有10例患者經過臨床治療，，LP的癥狀明顯減輕，另有10例患者并無明顯的改善，另有10例患者，癥狀呈明顯的惡化趨勢。為考察上述患者治療過程中的免疫學表達特點，以ELISA試劑盒測定患者外周者血的IL-20的濃度。并進行統(tǒng)計學分析，以確定IL-20在患者體內外周血表達水平及其相關性。 結果：通過對患者的IL-20在患者體內外周血表達水平及其變化特點可知，全部30例患者在治療初期IL-20的表達情況均明顯高于正常人外周血。并且，通過一個治療周期后發(fā)現，LP癥狀減輕的患者，其IL-20的表達有顯著性下降，但是仍然高于正常人外周血；LP癥狀惡化的患者，其IL-20的表達并無顯著變化，該結果表明， IL-20在患者發(fā)生扁平苔蘚的過程中，起到了顯著性的作用。但是，在進一步惡化過程中，IL-20并非主要因素。 結論：IL-20在患者LP發(fā)病過程中起到了顯著性作用，此參數的提高可以大大增加患者LP發(fā)病的風險；而在進一步的惡化過程中， IL-20的影響并不大，LP癥狀減輕的患者，其IL-20的表達有顯著性下降。從而確定，IL-20同患者的發(fā)病關系非常密切。
[Abstract]:Lichen planus (Lichen planus,LP) is a common chronic or subacute inflammatory skin disease, but it is not well studied at present, especially on its pathogenesis and related factors in the process of deterioration. LP is generally considered to be an autoimmune disease. Therefore, the expression of IL-20 in patients during the course of disease and treatment was studied in order to confirm the influence of IL-20, an immune factor, on the progression of LP. Objective: to analyze the changes of IL-20 expression in peripheral blood of patients with lichen planus (Lichen planus), and to provide strong support for the pathogenesis and advanced treatment of Lichen planus, so as to improve the therapeutic system of Lichen planus. At the same time, to further determine the pathogenesis of the disease to provide a strong clinical basis. Methods: the clinical treatment of 30 patients with LP was analyzed retrospectively. Among them, 10 patients with LP were obviously relieved after clinical treatment, and 10 patients had no significant improvement. In the other 10 patients, the symptoms showed an obvious trend of deterioration. In order to investigate the immunological expression characteristics of the patients, the concentration of IL-20 in peripheral blood was measured by ELISA kit. Statistical analysis was carried out to determine the expression of IL-20 in peripheral blood of patients and its correlation. Results: the expression of IL-20 in peripheral blood of all 30 patients was significantly higher than that of normal controls at the beginning of treatment. After a treatment cycle, the expression of IL-20 in patients with mild LP symptoms was significantly decreased, but the expression of IL-20 was still higher than that in patients with normal peripheral blood and LP symptoms, and there was no significant change in the expression of IL-20. The results suggest that IL-20 plays a significant role in the development of lichen planus. However, IL-20 is not a major factor in the process of further deterioration. ConclusionTwo -IL-20 plays a significant role in the pathogenesis of LP, and the increase of this parameter can greatly increase the risk of LP, but in the process of further deterioration, the effect of IL-20 is not significant in patients with lessening of LP symptoms. The expression of IL-20 decreased significantly. Thus it is determined that IL-20 is closely related to the onset of the disease.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R758.65

【參考文獻】

相關期刊論文 前8條

1 弓娟琴;肝炎病毒與皮膚疾病[J];國外醫(yī)學.皮膚性病學分冊;1997年04期

2 張延琳,王嘉陵,丁蕾,逄愛慧,李明,郭三蘭;扁平苔蘚患者血小板聚集和血液流變學研究[J];臨床口腔醫(yī)學雜志;2005年08期

3 丁政云;蔡麗;劉麗娟;李鑫;張曉君;李艷菊;;扁平苔蘚皮損MMP-2、MMP-9的表達及外周血MMP-9的檢測[J];中國麻風皮膚病雜志;2008年02期

4 通拉嘎;龐傳超;張玉榮;;扁平苔蘚病因及發(fā)病機制的研究進展[J];內蒙古民族大學學報(自然科學版);2011年04期

5 周郅軻;李艷軍;李勇堅;;尋常型銀屑病患者外周血單個核細胞Toll樣受體9基因和血清IL-20表達水平的研究[J];中國美容醫(yī)學;2012年12期

6 李澄,開元元,楊忠禮,趨林樾;PCR檢測石蠟包埋三種皮膚病皮損中乙型肝炎病毒觀察[J];中國皮膚性病學雜志;1997年06期

7 丁政云;李鑫;王欣;趙保廷;高順強;劉麗娟;蔡麗;徐素芹;;腫瘤壞死因子α在扁平苔蘚皮損中的表達[J];中華皮膚科雜志;2005年12期

8 李俊琴;李新華;張開明;;銀屑病和扁平苔蘚皮損ki-67及PCNA蛋白的表達[J];中國醫(yī)學文摘(皮膚科學);2008年05期

本文編號：2230482