【摘要】：目的：本研究通過對我院皮膚科2008年9月至2010年9月期間確診的113例兒童孢子絲菌病患者采用伊曲康唑進(jìn)行治療觀察,評估伊曲康唑治療兒童孢子絲菌病的臨床療效及安全性,為有效治療兒童孢子絲菌病、降低其復(fù)發(fā)率提供科學(xué)依據(jù)。 方法：113例患兒口服伊曲康唑膠囊5mg/kg體重,每日1次,囑患兒將藥物與油性食物同服；療程12周。若皮損炎癥明顯,加服抗生素1周。療程期間以及療程結(jié)束后2周末,每2周隨訪1次,觀察并詳細(xì)記錄皮損變化,全身及局部藥物不良反應(yīng),包括主、客觀癥狀。治療前后查血、尿常規(guī)及肝、腎功能。并于停藥后1個(gè)月、3個(gè)月、6個(gè)月各隨訪一次,隨訪內(nèi)容包括肝、腎功能變化及有無復(fù)發(fā)等。 結(jié)果：伊曲康唑治療兒童孢子絲菌病療效顯著,療程2周時(shí),總有效率為5.31%；療程4周時(shí),總有效率為40.71%；療程6周時(shí),總有效率為92.04%；療程8周時(shí),總有效率達(dá)98.23%。隨著療程的逐漸延長(2周至8周),總有效率不斷升高,差異皆有顯著性(P0.05)。而療程至8周以后,總有效率不變,基愈病例數(shù)持續(xù)增多。停藥后1個(gè)月隨訪113例患者中復(fù)發(fā)者2例,繼續(xù)治療1個(gè)月痊愈,肝功能異常者3例,繼續(xù)隨診恢復(fù)正常,無腎功能改變；停藥3個(gè)月隨訪復(fù)發(fā)1例,繼續(xù)治療1個(gè)月痊愈,肝腎功能變化的例數(shù)為0；停藥后6個(gè)月隨訪無復(fù)發(fā)。 結(jié)論：伊曲康唑治療兒童孢子絲菌病療效確切,不良反應(yīng)較少,肝腎功能損害發(fā)生率較低,服用方便,為治療的一種較好選擇。
[Abstract]:Objective: to evaluate the efficacy and safety of itraconazole in the treatment of spore mycosis in children by using itraconazole in 113 children who were diagnosed in our department of dermatology from September 2008 to September 2010. To provide a scientific basis for the effective treatment of spore mycosis in children and the reduction of its recurrence rate. Methods 113 children were given itraconazole capsule (5mg/kg) once a day for 12 weeks. If inflammation is evident, take antibiotics for 1 week. The patients were followed up every 2 weeks during the course of treatment and 2 weeks after the treatment. The changes of skin lesions, systemic and local adverse drug reactions, including subjective and objective symptoms, were observed and recorded in detail. Blood, urine routine and liver and kidney function were examined before and after treatment. The patients were followed up for 1 month, 3 months and 6 months, including liver, renal function and recurrence. Results: itraconazole was effective in the treatment of spore mycosis in children. The total effective rate was 5.31 at 2 weeks, 40.71at 4 weeks, 92.044 at 6 weeks and 98.23 at 8 weeks. With the gradual extension of the course of treatment (2 weeks to 8 weeks), the total effective rate continuously increased, the differences were significant (P0.05). After 8 weeks of treatment, the total effective rate remained unchanged, and the number of cases of basal healing continued to increase. Two of 113 patients were followed up for 1 month after drug withdrawal, 2 patients were cured after 1 month of continuous treatment, 3 patients with abnormal liver function returned to normal and no changes of renal function were followed up, 1 case was followed up for 3 months, and 1 case was cured after 1 month of treatment. The number of patients with liver and kidney function changes was 0, and no recurrence occurred 6 months after withdrawal. Conclusion: itraconazole is a better choice for the treatment of spore mycosis in children, with less adverse reactions, lower incidence of liver and kidney function damage and convenient administration of itraconazole.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R756.6

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