【摘要】： 目的：本研究使用激光共聚焦顯微鏡對(duì)光動(dòng)力治療鮮紅斑痣前后的療效進(jìn)行評(píng)價(jià)。 方法：本研究共選取34位臨床上確診為鮮紅斑痣的患者,給予兩次光動(dòng)力治療。第一次光動(dòng)力治療有約四分之一的患者為對(duì)照組,第二次光動(dòng)力治療不設(shè)對(duì)照組。每位患者分別于每次治療前,治療即刻后,治療四天后,治療8周后行共聚焦顯微鏡檢查。 結(jié)果：未治療的鮮紅斑痣皮損處與同一患者正常皮膚比較,平均血管密度和平均血管直徑均較大,有統(tǒng)計(jì)學(xué)差異。對(duì)照組第一次治療前與第一次治療后8周比較,平均血管密度和平均血管直徑無(wú)統(tǒng)計(jì)學(xué)差異。治療組第一次治療前與第二次治療后8周比較,平均血管密度有統(tǒng)計(jì)學(xué)差異,平均血管直徑無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論：共聚焦顯微鏡是一種觀察光動(dòng)力治療鮮紅斑痣有效,無(wú)創(chuàng)的檢測(cè)方法。
[Abstract]:Objective: to evaluate the efficacy of laser confocal microscopy before and after photodynamic treatment of nevus. Methods: in this study, 34 patients with nevus were treated twice with photodynamic therapy. About 1/4 of the patients in the first photodynamic therapy were in control group, and the second photodynamic therapy was not in the control group. Each patient was examined by confocal microscopy 8 weeks after each treatment, immediately after treatment, 4 days after treatment. Results: the mean blood vessel density and mean vessel diameter of the untreated nevus were larger than that of the normal skin of the same patient (P < 0.05). There was no significant difference in mean vessel density and mean vessel diameter between the control group and the control group before the first treatment and 8 weeks after the first treatment. In the treatment group, the mean vessel density was significantly different from that in the second treatment group at 8 weeks after the first treatment, and there was no significant difference in the mean vessel diameter between the first treatment group and the second treatment group. Conclusion: confocal microscope is an effective and non-invasive method for observing photodynamic therapy of nevus.
【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R758.51

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