【摘要】：目的惡性黑色素瘤(malignant melanoma,MM)是臨床上較為常見(jiàn)的高度惡性腫瘤,長(zhǎng)期以來(lái)致殘率和死亡率相當(dāng)高。本研究探討隔離熱灌注化療(hyperthermic isolated limb perfusion,HILP)技術(shù)應(yīng)用于MM的治療效果,并總結(jié)熱灌注經(jīng)驗(yàn)。方法收集2002-01-01-2016-06-30甘肅省腫瘤醫(yī)院骨與軟組織腫瘤科收治的93例ⅡB~Ⅲ期肢體MM患者的臨床資料,根據(jù)治療方案,將72例HILP配合手術(shù)患者納入觀察組,21例未行HILP的手術(shù)患者為對(duì)照組,術(shù)后隨訪觀察療效、局部復(fù)發(fā)、轉(zhuǎn)移、并發(fā)癥及化療毒性反應(yīng)等情況,兩組5年無(wú)瘤生存率(disease free survival,DFS)及5年總生存率(overall survival,OS)比較采用χ~2檢驗(yàn)。結(jié)果觀察組完全緩解率(complete response,CR)為63.9%(46/72),部分緩解率(partial response,PR)為26.4%(19/72),總緩解率(owerall response,OR)為90.3%,局部復(fù)發(fā)率(local recurrence,LR)為11.1%(8/72),保肢率(limb salvage,LS)為95.8%(69/72)。無(wú)死亡、致殘等嚴(yán)重并發(fā)癥,Wieberdink毒性反應(yīng)分級(jí)均為Ⅰ~Ⅲ級(jí)。觀察組與對(duì)照組5年DFS分別為44.4%(16/36)和14.3%(3/21),差異有統(tǒng)計(jì)學(xué)意義,P=0.02;5年OS分別為52.8%(19/36)和19.0%(4/21),差異有統(tǒng)計(jì)學(xué)意義,P=0.01。結(jié)論 HILP療效確切,毒副作用小,且安全性高,能降低LR,提高5年DFS及OS,該技術(shù)可在臨床上廣泛推廣及應(yīng)用。
[Abstract]:Objective malignant melanoma (malignant melanoma,MM) is one of the most common malignant tumors. The purpose of this study was to investigate the efficacy of isolated hyperthermic infusion chemotherapy (hyperthermic isolated limb perfusion,HILP) in the treatment of MM and summarize the experience of hyperthermic perfusion. Methods the clinical data of 93 patients with stage 鈪，

本文編號(hào)：2202910