光動力療法治療尿道口尖銳濕疣的臨床療效觀察
發(fā)布時間：2018-08-14 17:14
【摘要】： 本研究采用先用10%ALA溶液敷藥一次,30 min再用10%ALA乳膏敷藥一次,3h后用635 nm的紅光照射的光動力治療方案于2008年7月至2009年3月治療就診于我科的108例尿道口尖銳濕疣患者,觀察該方案的療效及安全性。經(jīng)1~6次治療,108例患者中104例痊愈,痊愈率96.3%;1次治療后痊愈率44.4%。104例患者治療后隨訪12個月,共有8例(7.69%)患者復發(fā)。所有經(jīng)治患者未發(fā)生系統(tǒng)不良反應,約半數(shù)患者光照時局部出現(xiàn)輕度灼傷或刺痛感,均可耐受。本研究方案與液氮、電離子、CO2激光以及外用細胞毒性藥物、免疫調(diào)節(jié)劑相比具有療效好、不良反應小、復發(fā)率低的優(yōu)點;與國內(nèi)外已報道的單純外用ALA溶液或單純外用ALA乳膏的方案比較具有操作簡便、敷藥時間短等優(yōu)勢,具有臨床應用價值。
[Abstract]:From July 2008 to March 2009, 108 patients with condyloma acuminatum of urethral orifice were treated with 10%ALA solution for 30 min and 10%ALA cream for 3 h, followed by 635nm red light irradiation, from July 2008 to March 2009, in our department, 108 patients with condyloma acuminatum of urethral orifice were treated. To observe the efficacy and safety of the regimen. 104 of 108 patients were cured after 1 and 6 times of treatment, and the cure rate was 96. 3%. The recovery rate was 44. 4%. 104 cases were followed up for 12 months after treatment. There were 8 cases (7. 69%) relapsed. There were no systemic adverse reactions in all the patients, and about half of the patients had mild burns or tingling during illumination, which could be tolerated. Compared with liquid nitrogen, electric ion CO _ 2 laser and external cytotoxic drugs, this scheme has the advantages of better curative effect, less adverse reaction and lower recurrence rate. Compared with ALA solution or ALA cream reported at home and abroad, it has the advantages of simple operation, short application time, and has clinical application value.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R752.53
本文編號：2183552
[Abstract]:From July 2008 to March 2009, 108 patients with condyloma acuminatum of urethral orifice were treated with 10%ALA solution for 30 min and 10%ALA cream for 3 h, followed by 635nm red light irradiation, from July 2008 to March 2009, in our department, 108 patients with condyloma acuminatum of urethral orifice were treated. To observe the efficacy and safety of the regimen. 104 of 108 patients were cured after 1 and 6 times of treatment, and the cure rate was 96. 3%. The recovery rate was 44. 4%. 104 cases were followed up for 12 months after treatment. There were 8 cases (7. 69%) relapsed. There were no systemic adverse reactions in all the patients, and about half of the patients had mild burns or tingling during illumination, which could be tolerated. Compared with liquid nitrogen, electric ion CO _ 2 laser and external cytotoxic drugs, this scheme has the advantages of better curative effect, less adverse reaction and lower recurrence rate. Compared with ALA solution or ALA cream reported at home and abroad, it has the advantages of simple operation, short application time, and has clinical application value.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R752.53
【參考文獻】
相關(guān)期刊論文 前10條
1 謝寶剛,黃慧芳,黃劍東,陳耐生,黃金陵;K562細胞攝取光敏劑ZnPcS_2P_2的測定及藥代動力學[J];光譜學與光譜分析;2004年11期
2 郭紅衛(wèi);尖銳濕疣的免疫學發(fā)病機制[J];國外醫(yī)學.皮膚性病學分冊;2001年05期
3 鄭和義;朱學駿;連石;蘇曉紅;賴維;李軍;王愛平;朱威;蔣明軍;萬苗堅;;5%咪喹莫特乳膏治療尖銳濕疣的多中心、隨機雙盲、對照研究[J];國際皮膚性病學雜志;2006年01期
4 林善良;光動力治療藥物研究進展[J];國外醫(yī)學(放射醫(yī)學核醫(yī)學分冊);1999年03期
5 梁伶;復發(fā)性尖銳濕疣誘發(fā)因素的探討[J];廣西醫(yī)科大學學報;2001年03期
6 章偉,錢伊弘,張剛,顧志英;0.5%鬼臼毒素治療尖銳濕疣的療效分析[J];臨床皮膚科雜志;2001年03期
7 路濤,陳萍,王俐,黃雄,陳有仁;CO_2激光聯(lián)合5%咪喹莫特軟膏治療尖銳濕疣療效觀察[J];臨床皮膚科雜志;2005年05期
8 李軍;;電離子加5%咪喹莫特乳膏治療尖銳濕疣療效觀察[J];浙江臨床醫(yī)學;2008年08期
9 陳木開;謝繼璜;李玉華;廖綺曼;韓建德;;光動力治療尖銳濕疣療效和影響因素分析[J];中國熱帶醫(yī)學;2009年10期
10 肖立新;韓秀娟;;更昔洛韋聯(lián)合液氮冷凍治療尖銳濕疣臨床觀察[J];臨床和實驗醫(yī)學雜志;2008年08期
，本文編號：2183552
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