【摘要】： 本研究采用先用10%ALA溶液敷藥一次,30 min再用10%ALA乳膏敷藥一次,3h后用635 nm的紅光照射的光動(dòng)力治療方案于2008年7月至2009年3月治療就診于我科的108例尿道口尖銳濕疣患者,觀察該方案的療效及安全性。經(jīng)1~6次治療,108例患者中104例痊愈,痊愈率96.3%;1次治療后痊愈率44.4%。104例患者治療后隨訪12個(gè)月,共有8例(7.69%)患者復(fù)發(fā)。所有經(jīng)治患者未發(fā)生系統(tǒng)不良反應(yīng),約半數(shù)患者光照時(shí)局部出現(xiàn)輕度灼傷或刺痛感,均可耐受。本研究方案與液氮、電離子、CO2激光以及外用細(xì)胞毒性藥物、免疫調(diào)節(jié)劑相比具有療效好、不良反應(yīng)小、復(fù)發(fā)率低的優(yōu)點(diǎn);與國(guó)內(nèi)外已報(bào)道的單純外用ALA溶液或單純外用ALA乳膏的方案比較具有操作簡(jiǎn)便、敷藥時(shí)間短等優(yōu)勢(shì),具有臨床應(yīng)用價(jià)值。
[Abstract]:From July 2008 to March 2009, 108 patients with condyloma acuminatum of urethral orifice were treated with 10%ALA solution for 30 min and 10%ALA cream for 3 h, followed by 635nm red light irradiation, from July 2008 to March 2009, in our department, 108 patients with condyloma acuminatum of urethral orifice were treated. To observe the efficacy and safety of the regimen. 104 of 108 patients were cured after 1 and 6 times of treatment, and the cure rate was 96. 3%. The recovery rate was 44. 4%. 104 cases were followed up for 12 months after treatment. There were 8 cases (7. 69%) relapsed. There were no systemic adverse reactions in all the patients, and about half of the patients had mild burns or tingling during illumination, which could be tolerated. Compared with liquid nitrogen, electric ion CO _ 2 laser and external cytotoxic drugs, this scheme has the advantages of better curative effect, less adverse reaction and lower recurrence rate. Compared with ALA solution or ALA cream reported at home and abroad, it has the advantages of simple operation, short application time, and has clinical application value.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R752.53

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