【摘要】：患者男,80歲。周身色素沉著、灰褐色斑丘疹伴癢1年,水皰1周。斑塊組織病理示:表皮角化過度,乳頭瘤樣增生,真皮淺層多量炎性細胞浸潤。水皰組織病理示:表皮下形成大皰,皰內(nèi)可見嗜酸性粒細胞、淋巴細胞、中性粒細胞。免疫熒光示:Ig G,Ig M,C3呈線狀沉積。胃鏡示:食管下端一菜花狀隆起,表面粗糙不平,管腔狹窄。組織病理示:癌組織呈腺管狀或巢團狀,細胞核大深染;免疫組織化學(xué)結(jié)果:癌組織CK18(+),C-erb B-2(+)。診斷:惡性黑棘皮病,食管癌(腺癌),大皰性類天皰瘡。
[Abstract]:The patient was 80 years old. Pigmentation, grayish brown macular papules with itching for 1 year and blister for 1 week. The histopathology of the plaques showed that epidermis keratosis, papillomatous hyperplasia and multiple inflammatory cell infiltration in the superficial dermis. Blister histopathology showed that bullae was formed under the epidermis, eosinophils, lymphocytes and neutrophils were found in the blister. The immunofluorescence showed that the C _ 3 of G _ (G) G _ (鈪，

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