【摘要】： 目的:通過檢測白癜風(fēng)患者血漿中內(nèi)皮素-1和降鈣素基因相關(guān)肽的水平變化,探討二者與白癜風(fēng)發(fā)病及病情活動的相關(guān)性,為白癜風(fēng)的發(fā)病機(jī)制研究及治療提供新的理論依據(jù)。 方法:選擇湖南省衡陽地區(qū)漢族人群白癜風(fēng)患者60名和40名健康志愿者為研究對象,采肘靜脈血5毫升,取血漿,應(yīng)用ELISA法檢測血漿中ET-1及CGRP的濃度。 結(jié)果:1白癜風(fēng)患者血漿中ET-1的濃度低于健康對照組(P0.05),進(jìn)展期白癜風(fēng)患者血漿中ET-1的濃度低于穩(wěn)定期與健康對照組(P0.01),泛發(fā)型白癜風(fēng)患者血漿中ET-1的濃度明顯低于局限型與健康對照組(P0.01)。而穩(wěn)定期與局限型白癜風(fēng)患者血漿中ET-1的濃度與健康對照組無明顯差異(P0.05)。 2白癜風(fēng)患者血漿中CGRP的濃度明顯高于健康對照組(P0.01),進(jìn)展期白癜風(fēng)患者血漿中CGRP的濃度,明顯高于穩(wěn)定期和健康對照組(P0.01),而泛發(fā)型白癜風(fēng)患者血漿中CGRP的濃度明顯高于局限型與健康對照組(P0.01)。而穩(wěn)定期與局限型型白癜風(fēng)患者血漿中CGRP的濃度與健康對照組無明顯差異(P0.05)。 3白癜風(fēng)患者組血漿中的ET-1與CGRP的濃度相關(guān)系數(shù)為-0.72(r=-0.72 p=0.002),呈負(fù)相關(guān)。進(jìn)展期白癜風(fēng)患者血漿中ET-1與CGRP的濃度相關(guān)系數(shù)為-0.45(r=-0.538 p=0.002),呈負(fù)相關(guān)。泛發(fā)型白癜風(fēng)患者血漿中ET-1與CGRP的濃度相關(guān)系數(shù)為-0.52(r=-0.376 p=0.04),呈負(fù)相關(guān)。 結(jié)論:1 ET-1和CGRP與白癜風(fēng)發(fā)病有關(guān)。 2白癜風(fēng)病情活動時,ET-1和CGRP呈負(fù)相關(guān)。
[Abstract]:Objective: to investigate the relationship between plasma endothelin-1 and calcitonin gene-related peptide levels in patients with vitiligo, and to provide a new theoretical basis for the study and treatment of vitiligo. Methods: 60 patients with vitiligo and 40 healthy volunteers in Hengyang area of Hunan province were selected. The plasma levels of ET-1 and CGRP were determined by Elisa. Results the concentration of ET-1 in plasma of patients with vitiligo was lower than that of healthy controls (P0.05), and that of patients with advanced vitiligo was lower than that of healthy controls (P0.01). The concentration of ET-1 in patients with generalized vitiligo was significantly lower than that in patients with generalized vitiligo (P0.01). Limited type and healthy control group (P0.01). However, there was no significant difference in plasma ET-1 levels between stable and localized vitiligo patients and healthy controls (P0.05). 2 the plasma levels of CGRP in vitiligo patients were significantly higher than those in healthy controls (P0.01), and CGRP concentrations in plasma of advanced vitiligo patients were significantly higher than those of healthy controls (P0.01). The plasma levels of CGRP in patients with generalized vitiligo were significantly higher than those in the control group (P0.01). However, there was no significant difference in plasma CGRP concentration between stable and localized vitiligo patients (P0.05). 3 the correlation coefficient between plasma ET-1 and CGRP concentration in patients with vitiligo was -0.72 (r = -0.72 p ~ (0.002), which was negatively correlated. The correlation coefficient between plasma ET-1 and CGRP in patients with vitiligo was -0.45 (r ~ (-0.538) p ~ (0.002), which was negatively correlated. The correlation coefficient between plasma ET-1 and CGRP in patients with generalized vitiligo was -0.52 (r ~ (-0.376) p ~ (0.04), which was negatively correlated. Conclusion 1 et-1 and CGRP are associated with vitiligo. 2 there is a negative correlation between et-1 and CGRP when vitiligo is active.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R758.41

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