白癜風(fēng)與老年性白斑臨床特征和皮損超微結(jié)構(gòu)比較
本文選題:白癜風(fēng) + 老年性白斑 ; 參考:《中國皮膚性病學(xué)雜志》2016年08期
【摘要】:目的評價白癜風(fēng)與老年性白斑的病因?qū)W及臨床表現(xiàn)和轉(zhuǎn)歸的異同,以期為白癜風(fēng)的病因和治療方法的研究提供全新的理論支持。方法采用調(diào)查問卷、查體和電子顯微鏡等手段獲得患者在病因、皮損超微結(jié)構(gòu)和臨床特征等方面異同的數(shù)據(jù)。結(jié)果白癜風(fēng)和老年性白斑共同特征為皮損表現(xiàn)均呈瓷白色;超微結(jié)構(gòu)均無可見黑素細胞。但兩者卻存在其他諸多不同:白癜風(fēng)可以發(fā)生于各個年齡段;皮損常常反復(fù)加重并融合成大片損害;而老年性白斑主要發(fā)生于成年人,尤其是中年以上患者,皮損數(shù)目可以不斷增多,但皮損面積卻一直維持在黃豆大小以下。結(jié)論白癜風(fēng)和老年性白斑同屬色素脫失類疾病,但除了皮損顏色改變相似外,二者臨床表現(xiàn)有較大差異,二者的對比研究也許會為白癜風(fēng)的研究提供不同的思路。
[Abstract]:Objective to evaluate the etiology, clinical manifestation and outcome of vitiligo and senile plaque in order to provide new theoretical support for the study of the etiology and treatment of vitiligo. Methods the data of etiology, ultrastructure and clinical features of lesions were obtained by questionnaire, physical examination and electron microscope. Results the common features of vitiligo and senile leukoplakia were that the lesions were porcelain white and no melanocytes were found in the ultrastructure. But there are many other differences: vitiligo can occur at all ages; lesions are often repeatedly aggravated and fused into large areas of damage; and age-related leukoplakia occurs mainly in adults, especially in patients older than middle age. The number of skin lesions can be increased, but the area of skin lesions has been maintained below the size of soybeans. Conclusion vitiligo and senile leukoplakia are both pigmented loss diseases, but there are great differences in their clinical manifestations except for the same color changes in skin lesions. The comparative study between the two may provide different ideas for the study of vitiligo.
【作者單位】: 西安交通大學(xué)第一附屬醫(yī)院皮膚性病科;
【基金】:國家自然科學(xué)基金面上項目(81171504)
【分類號】:R758.41
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