本文選題：慢性局限性濕疹 + 花椒油��； 參考：《湖北中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的探討外用花椒油治療慢性局限性濕疹的療效。方法1.收集符合入選標(biāo)準(zhǔn)的57例慢性局限性濕疹患者,按照就診順序隨機(jī)分為實(shí)驗(yàn)組和對(duì)照組。實(shí)驗(yàn)組予以花椒油外搽,2次/天,對(duì)照組予以地奈德乳膏外用,2次/天,治療周期為2周。2.在治療前及治療第2周末評(píng)估記錄各觀察指標(biāo)包括瘙癢評(píng)分(VAS)、皮損評(píng)分(EASI),并記錄其不良反應(yīng),由同一人為患者照相,進(jìn)行圖片采集。3.所得數(shù)據(jù)均采用雙側(cè)檢驗(yàn),以秩和檢驗(yàn)比較組內(nèi)治療前后及組間有關(guān)計(jì)量資料,卡方檢驗(yàn)檢驗(yàn)比較計(jì)數(shù)資料,顯著性檢驗(yàn)水平為0.05,P≤0.05為差異有統(tǒng)計(jì)學(xué)意義,P≥0.05為差異無(wú)統(tǒng)計(jì)學(xué)意義,比較療效。結(jié)果1.共55例患者完成了臨床研究。實(shí)驗(yàn)組治愈、顯效、好轉(zhuǎn)、無(wú)效人數(shù)分別為1人、3人、17人、7人,總有效率75%。對(duì)照組治愈、顯效、好轉(zhuǎn)、無(wú)效人數(shù)分別為2人、3人、16人、6人,總有效率77.8%。兩組之間差異無(wú)統(tǒng)計(jì)學(xué)差異P0.05。2.實(shí)驗(yàn)組、對(duì)照組中瘙癢評(píng)分、皮損評(píng)分、癥狀總積分各評(píng)分與初診比較顯著降低,P0.001;實(shí)驗(yàn)組和對(duì)照組癥狀積分相比較,P=0.6920.05,說(shuō)明兩組之間療效沒(méi)有統(tǒng)計(jì)學(xué)差異。3.實(shí)驗(yàn)組瘙癢和皮損評(píng)分分別從治療前的2.38±0.56、12.27±5.73降為0.79±0.71、7.77±4.08(P0.001);對(duì)照組瘙癢和皮損評(píng)分分別從治療前的2.41±0.636、11.72±3.24降為0.76±0.74、7.19±3.48(P0.001);且兩組在治療后評(píng)分較治療前顯著降低(P0.001)。4.實(shí)驗(yàn)組癥狀總積分在治療前為14.64±5.95,治療后降為8.55±4.23,顯著降低;對(duì)照組癥狀總積分在治療前為14.13±3.61,治療后降為7.94±4.00,也顯著降低,且兩組之間癥狀總積分無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論外用花椒油治療慢性局限性濕疹可以有效緩解患者的瘙癢不適、減輕皮損癥狀,同時(shí)安全性高,有較好的推廣價(jià)值。
[Abstract]:Objective to investigate the effect of zanthoxylum oil on chronic localized eczema. (1.) to collect 57 patients with chronic localized eczema, which were randomly divided into experimental and control groups according to the order of admission. The experimental group was treated with zanthoxylum oil outside, 2 times / day, and the control group was treated with Desonide cream for 2 times / day, and the treatment cycle was 2 weeks.2.. Before and after second weeks of treatment, the observation indexes including pruritus score (VAS), skin lesion score (EASI), and their adverse reactions were recorded by the same person, and the data collected by.3. were both bilateral test, and the relative measurement data were compared before and after treatment in the group. The number of data, the level of significant test was 0.05, P < 0.05 was statistically significant, P > 0.05 was no statistical significance, and the effect was compared. Results 1. of the 55 patients completed clinical study. The experimental group was cured, effective, and improved, the number of invalid was 1, 3, 17, 7, total effective, 75%. control group cured, effective, improved, invalid. 2 people, 3 people, 16 people, 6 people, the total effective 77.8%. two groups had no statistical difference between the P0.05.2. experimental group, the control group in the pruritus score, the skin lesion score, the total score of the symptom and the initial diagnosis were significantly lower, P0.001; the experimental group and the control group were compared with the symptom score, P=0.6920.05, indicating that there was no statistical difference between the two groups. The pruritus and skin lesions of the.3. group decreased from 2.38 + 0.56,12.27 + 5.73 before treatment to 0.79 + 0.71,7.77 + 4.08 (P0.001), and the pruritus and skin lesions of the control group decreased from 2.41 + 0.636,11.72 + 3.24 before treatment to 0.76 + 0.74,7.19 + 3.48 (P0.001), and the scores of the two groups were significantly lower than those before treatment (P0.001).4. experimental group. The total score was 14.64 + 5.95 before treatment and decreased to 8.55 + 4.23 after treatment. The total score of symptoms in the control group was 14.13 + 3.61 before treatment and 7.94 + 4 after treatment. There was no significant difference in the total symptom score between the two groups (P0.05). Conclusion external use of pepper oil for chronic localized eczema could effectively relieve the patients. Itching is not good, relieve the symptoms of skin lesions, and at the same time, it has high safety, and has a good promotional value.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R758.23

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