本文選題：HPV型 + 跖疣��； 參考：《安徽醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的檢測感染成人跖疣患者的人乳頭瘤病毒(human papillomavirus,HPV)型,了解中國成人跖疣患者中HPV型的分布并探討其與臨床特征之間的關(guān)系。方法采用PCR(Polymerase Chain Reaction,PCR)技術(shù)檢測221例成人跖疣患者HPV型;使用TA克隆(TA cloning)載體技術(shù)對混合感染的病毒進行分型;記錄患者的年齡、病程、癥狀和疣體數(shù),分析HPV型與患者臨床特征之間的關(guān)聯(lián)性。結(jié)果檢測標本的陽性率為97.3%(215/221)。本研究總共檢測出3個“屬”和5個“種”(α“屬”第4和8“種”,γ“屬”第1“種”,μ“屬”第1和2“種”),共7個“型”(HPV 27、1、2、57、63、65和7)。單一HPV型感染患者占96%(206/215),其型別有HPV 27、2、57和7(Alpha屬)、HPV-65(Gamma屬)和HPV 1、63(Mu屬),分別占44.7%、12.1%、7.3%、0.5%、0.5%、33.5%和1.5%�；旌闲透腥净颊哒�4.0%(9/215),混合型別有HPV-1和27、HPV-1和2、HPV-2和27、HPV-1、2和27,分別占55.6%(5/9)、22.2%(2/9)、11.1%(1/9)和11.1%(1/9),HPV-1/27在混合感染中最多見。單一型感染型別構(gòu)成與按照比例權(quán)重分布法計算的型別構(gòu)成相似。22例鑲嵌疣均為單一型感染,所感染的型別有HPV-27、2、1、7、57和63,分別占50.0%(11/22)、22.7%(5/22)、13.6%(3/22)、4.5%(1/22)、4.5%(1/22)和4.5%(1/22)。HPV 2、27和57三種型別感染跖疣患者之間的中位年齡、病程、疣體個數(shù)、疼痛的發(fā)生率和性別比均無差異(P值0.05)。HPV 27感染者具有年齡30歲、病程1年、疣體個數(shù)2個、疼痛發(fā)生率低少見的特點,與α屬感染者相似。HPV 1感染者與年齡≤30歲、病程≤1年、疣體數(shù)≤2個和疼痛高發(fā)生率相關(guān),與μ屬感染者基本相同。結(jié)論HPV 27、2、57和1是感染成人跖疣患者的主要HPV型。HPV 1和27型感染者的臨床特征存在很大差異。跖疣相關(guān)HPV型與患者的臨床特征之間存在著緊密的相關(guān)性。
[Abstract]:Objective to investigate the distribution of human papillomavirus (HPV) in Chinese adults with metatarsal warts and its relationship with clinical features. Methods the HPV type of 221 adult patients with metatarsal warts was detected by PCR Polymerase chain reaction PCR, TA clone TA cloning-based vector technique was used to type the mixed infection virus, and the age, course, symptoms and warts of the patients were recorded. To analyze the relationship between HPV type and clinical features of patients. Results the positive rate of the tested specimens was 97.3 / 221%. A total of 3 "genera" and 5 "species" ("4th and 8th" species "of 偽" genera "," 1st "species of 緯" genera "and" 1st and 2nd "species of 渭" genera) were detected in this study. The patients with single HPV-type infection accounted for 96 / 206 / 215, and there were 27HPV-2C57 and 7(Alpha belonging to HPV-65Gamma) and HPV-63Mu (44.7 12.30.5% and 1.533%, respectively). HPV-1 and HPV-2 and HPV-1 and 27HPV-2 and HPV-1 / 27, 55.6 / 9 / 2 / 22. 2 / 9 / 11 / 1 / 9, respectively, and 11.1 / 1 / 9 / 1 / 27 of HPV-1 / 27 were most common in mixed infections. The composition of single type infection was similar to that calculated by the method of proportional weight distribution. 22 cases of mosaic verruca were all single type infection. The types of infection included HPV-272HPV2HPV2HPV2HPV757 and HPV-27, accounting for 50.05 / 22 / 22 / 22.7g / 522 / 13.6A / 3 / 22 / 4.555 / 1.22) and 4.522.HPV227 / 57 respectively. There was no difference in the median age, course of disease, number of warts, incidence of pain and sex ratio among the three types of verruca infections (P = 0.05.HPV-27). There was no difference in age (P = 0.05.HPV27) between the three types of warts infected with HPV-277.The incidence of pain and sex ratio was 0.05.HPV27. In one year, the number of warts was 2, and the incidence of pain was low and rare. The incidence of pain was similar to that of 偽 -infected persons. HPV1 infection was correlated with age 鈮，

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