本文選題：他克莫司 + 外陰��； 參考：《重慶醫(yī)學(xué)》2014年25期

【摘要】：目的評價0.03%他克莫司軟膏治療女童外陰硬化性苔蘚(LS)的療效及安全性。方法 24例女童局部外用0.03%他克莫司軟膏每日2次,連續(xù)4周,再每晚1次,連續(xù)12周,總療程16周。每4周隨訪1次,記錄癥狀和皮損變化。療程結(jié)束后第3、6個月隨訪,記錄復(fù)發(fā)情況。結(jié)果 95.83%的女童對治療有應(yīng)答,療程16周時的完全緩解率高于療程8周時;病程短于1年的女童療效高于病程超過1年的;停藥后6個月的復(fù)發(fā)率高于停藥3個月時。結(jié)論 0.03%他克莫司軟膏治療女童外陰硬化性苔蘚安全、有效。
[Abstract]:Objective to evaluate the efficacy and safety of 0.03% tacrolimus ointment in the treatment of vulva lichen sclerosus in girls. Methods 24 girls were treated with 0.03% tacrolimus ointment twice a day for 4 weeks and once every night for 12 weeks. The total course of treatment was 16 weeks. The patients were followed up every 4 weeks to record the changes of symptoms and lesions. The recurrence was recorded at 3 and 6 months after the end of the course of treatment. Results 95.83% of the girls responded to the treatment, the complete remission rate at 16 weeks of treatment was higher than that at 8 weeks, the curative effect of girls with a course of less than 1 year was higher than that of more than 1 year, and the recurrence rate at 6 months after withdrawal was higher than that at 3 months after withdrawal. Conclusion 0.03% tacrolimus ointment is safe and effective in the treatment of vulvar lichen sclerosus in girls.
【作者單位】： 重慶醫(yī)科大學(xué)兒童醫(yī)院皮膚科;
【分類號】：R751.05

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