發(fā)布時間：2018-06-18 05:05

  本文選題：皮膚屏障 + 神經(jīng)酰胺�。� 參考：《中國皮膚性病學(xué)雜志》2016年09期

【摘要】：目的研究保濕劑對成人輕度特應(yīng)性皮炎治療前后皮膚角質(zhì)層神經(jīng)酰胺含量及含水量的變化。方法本實(shí)驗(yàn)選取25例成人輕度特應(yīng)性皮炎患者和10例健康對照者進(jìn)行研究,特應(yīng)性皮炎患者外用保濕劑治療;采用膠帶剝離法采集實(shí)驗(yàn)組和對照組前臂屈側(cè)皮膚角質(zhì)層樣本,用高效液相色譜 質(zhì)譜法聯(lián)用定量檢測角質(zhì)層神經(jīng)酰胺3含量,用SOFT 5.5皮膚性質(zhì)測試儀測定皮膚含水量;分析治療前后患者皮膚神經(jīng)酰胺3含量及含水量的變化,并根據(jù)EASI評分法評價療效。結(jié)果實(shí)驗(yàn)組皮膚角質(zhì)層神經(jīng)酰胺3含量(0.89±0.49)ng/mg、含水量(31.97±12.04)均低于健康對照組[(10.22±2.69)ng/mg和(67.81±11.05)],兩組差異有統(tǒng)計(jì)學(xué)意義(P0.05);實(shí)驗(yàn)組治療4周后皮膚角質(zhì)層神經(jīng)酰胺3含量(2.28±0.69)ng/mg和含水量(50.54±17.22)均高于治療前,差異有統(tǒng)計(jì)學(xué)意義(P0.05);EASI評分治療后(0.73±0.66)較治療前(2.37±1.50)下降,差異有統(tǒng)計(jì)學(xué)意義(P0.05);皮膚含水量與角質(zhì)層神經(jīng)酰胺3含量呈正相關(guān)關(guān)系(r=0.51,P0.05),與EASI評分呈負(fù)相關(guān)關(guān)系(r=-0.49,P0.05)。結(jié)論成人輕度特應(yīng)性皮炎患者皮膚角質(zhì)層神經(jīng)酰胺3含量下降,使用保濕劑輔助治療能促進(jìn)患者癥狀減輕。
[Abstract]:Objective to study the changes of ceramide content and water content in keratinocytes of adult patients with mild atopic dermatitis treated with moisturizer. Methods 25 adult patients with mild atopic dermatitis and 10 healthy controls were selected to study the treatment of atopic dermatitis with external moisturizer, and the samples of the cuticle of the forearm flexion of the experimental group and the control group were collected by using adhesive tape stripping method. The content of ceramide 3 in the cuticle and the skin water content in the cuticle were measured by HPLC / MS, and the changes of ceramide 3 content and water content in the skin before and after treatment were analyzed. The curative effect was evaluated according to EASI scoring method. Results the content of ceramide 3 in the cuticle of the experimental group was 0.89 鹵0.49 ng / mg and the water content was 31.97 鹵12.04), which was significantly lower than that in the healthy control group (10.22 鹵2.69)ng/mg and 67.81 鹵11.05), and the content of ceramide 3 and water content in the cuticular layer of the experimental group were 2.28 鹵0.69)ng/mg and 50.54 鹵17.22 respectively after 4 weeks of treatment. The difference was statistically significant (P 0.05 鹵0.66) compared with that before treatment (2.37 鹵1.50), and the skin water content was positively correlated with the content of ceramide 3 in the cuticle, and negatively correlated with the EASI score. Conclusion the content of ceramide 3 in the keratinocytes of patients with mild atopic dermatitis was decreased.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第二醫(yī)院皮膚科;
【基金】：廣東省科技計(jì)劃2013年資助課題(2013B021800297)
【分類號】：R758.2

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