發(fā)布時(shí)間：2018-06-13 01:16

  本文選題：非阿司匹林類非甾體抗炎藥 + 皮膚癌��； 參考：《腫瘤防治研究》2014年08期

【摘要】：目的評(píng)價(jià)非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風(fēng)險(xiǎn)的關(guān)系。方法檢索PubMed(Medline),EMBASE,BIOSIS,Cochrane圖書館,中國(guó)知網(wǎng)數(shù)據(jù)庫(CNKI)獲取有關(guān)非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風(fēng)險(xiǎn)的研究。按照納入標(biāo)準(zhǔn)進(jìn)行文獻(xiàn)篩查、質(zhì)量評(píng)價(jià)和資料提取。應(yīng)用Stata軟件計(jì)算總體OR值及95%置信區(qū)間,并進(jìn)行偏倚分析。當(dāng)異質(zhì)性可以接受時(shí),選用固定效應(yīng)模型對(duì)各研究原始數(shù)據(jù)進(jìn)行合并。結(jié)果納入非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風(fēng)險(xiǎn)的相關(guān)臨床研究文獻(xiàn)10篇,共12個(gè)獨(dú)立研究,累計(jì)皮膚癌患者482 264例,合并分析結(jié)果:OR值為1.00,95%CI:0.98~1.02。結(jié)論無足夠的證據(jù)證明非阿司匹林類非甾體抗炎藥與皮膚癌發(fā)病風(fēng)險(xiǎn)相關(guān)。仍需大規(guī)模臨床隨機(jī)對(duì)照試驗(yàn)來證實(shí)該結(jié)果。
[Abstract]:Objective to evaluate the relationship between non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of skin cancer. Methods A study on non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of skin cancer was obtained by searching the PubMeden Medline EMBASE Bios Cochrane Library and CNKI. Document screening, quality evaluation and data extraction according to inclusion criteria. Total OR and 95% confidence interval were calculated by Stata software and bias analysis was carried out. When heterogeneity is acceptable, fixed effect models are used to merge the original data. Results there were 10 clinical studies on non-aspirin non-steroidal anti-inflammatory drugs and the risk of skin cancer. There were 12 independent studies in which there were 482,264 patients with skin cancer. The combined analysis showed that the OR value of the combined analysis was 1.0095 CI: 0.98 + 1.02. Conclusion there is insufficient evidence that non-aspirin non-steroidal anti-inflammatory drugs are associated with the risk of skin cancer. Large-scale randomized controlled trials are still needed to confirm the results.
【作者單位】： 南方醫(yī)科大學(xué)南方醫(yī)院肝臟腫瘤中心;南方醫(yī)科大學(xué)腫瘤中心;南方醫(yī)科大學(xué)中西醫(yī)結(jié)合醫(yī)院腫瘤科;
【基金】：廣東省自然科學(xué)基金重點(diǎn)項(xiàng)目(10251051501000008)
【分類號(hào)】：R739.5

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