本文選題：成人線狀I(lǐng)gA大皰性皮病 + 　； 參考：《中國(guó)皮膚性病學(xué)雜志》2017年03期

【摘要】：目的了解成人線狀I(lǐng)g A大皰性皮病的臨床特點(diǎn)。方法回顧性分析本院經(jīng)治的4例及既往國(guó)內(nèi)文獻(xiàn)報(bào)道的15例成人線狀I(lǐng)g A大皰性皮病的臨床資料。結(jié)果共19例,其中男12例,女7例,平均發(fā)病年齡(39.42±17.12)歲。皮損好發(fā)于軀干及四肢,頭、面、頸、口腔黏膜和會(huì)陰部位亦可受累。較之兒童型,成人皮疹更具多形性。典型皮損組織病理示:表皮下水皰或裂隙形成,真皮乳頭及真皮淺層可見(jiàn)中性、嗜酸性粒細(xì)胞及淋巴細(xì)胞等炎癥細(xì)胞浸潤(rùn)。直接免疫熒光見(jiàn)基底膜帶Ig A線狀沉積,可伴C_3沉積,部分伴Ig G和Ig M沉積。氨苯砜、糖皮質(zhì)激素及多種免疫抑制劑等治療效果較好。結(jié)論本病好發(fā)于20~50歲人群,病程慢性,部分可自行緩解,診斷依賴(lài)組織病理及直接免疫熒光檢查,治療首選氨苯砜。
[Abstract]:Objective to investigate the clinical features of linear Ig A bullous dermatosis in adults. Methods the clinical data of 4 cases treated by our hospital and 15 cases of adult linear Ig A bullous dermatosis were retrospectively analyzed. Results there were 19 cases, including 12 males and 7 females, with an average age of 39.42 鹵17.12 years. Lesions may occur in the trunk and limbs, head, face, neck, oral mucosa and perineum. Adult rashes are more pleomorphic than children's. Histopathology of typical lesions showed the formation of subepidermal blister or fissure, neutrophil, eosinophilic granulocyte and lymphocyte infiltration in dermis papilla and superficial dermis. Direct immunofluorescence was observed in the basal membrane zone with Ig A linear deposition, which could be accompanied by CST3 deposition, and partly with Ig G and IgM deposition. Dapsone, glucocorticoid and various immunosuppressants are effective. Conclusion the disease is prone to occur in 2050 years old people, the course of disease is chronic, partial self-remission, the diagnosis depends on histopathology and direct immunofluorescence examination, the first choice of treatment is dapsone.
【作者單位】： 鄭州大學(xué)臨床醫(yī)學(xué)系;
【分類(lèi)號(hào)】：R758.66

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相關(guān)期刊論文 前10條

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本文編號(hào)：1992863