本文選題：尖銳濕疣 + 電離子��； 參考：《大連醫(yī)科大學(xué)》2011年碩士論文

【摘要】：目的:觀察比較三種治療尖銳濕疣方法的療效并探討聯(lián)合治療尖銳濕疣臨床療效。 方法:回顧收集2008年12月~2010年11月就診于大連醫(yī)科大學(xué)附屬二院皮膚科門診,并已確診為尖銳濕疣的患者76例,患者年齡在18-55歲之間,將76例的尖銳濕疣患者隨機分為3組:A組20例、B組21例、C組35例。A、B、C三組患者在年齡、性別、皮損數(shù)目、大小、病程上的差異無顯著性(P0.05),具有可比性。治療前詳細了解患者基本病情和發(fā)病相關(guān)情況,在治療和觀察中,由同一位觀察者進行治療及記錄皮損的愈合情況。A組單純多功能電離子治療機治療;B組多功能電離子治療機治療,外涂干擾素α-2b凝膠于患處,3次/d,連用8周;C組在B組基礎(chǔ)上肌注干擾素α-2b注射液100萬IU,每周3次,4周為一療程,連用2個療程,共8周。B、C組外用干擾素凝膠次數(shù)和方法均相同。6個月后觀察三組患者治療前后皮損變化并記錄其不良反應(yīng)。比較三組治療效果及尖銳濕疣復(fù)發(fā)率。并對結(jié)果采用SPSS17.0統(tǒng)計學(xué)軟件進行統(tǒng)計學(xué)數(shù)據(jù)處理,所得到的數(shù)據(jù)為計數(shù)資料,并使用卡方檢驗,取用P值0.05,差異有統(tǒng)計學(xué)意義。 結(jié)果:三組治愈率分別為35.0%、71.4%及94.3% ,復(fù)發(fā)率分別為65%、28.6%及5.7%。A組單純使用電離子治療尖銳濕疣,復(fù)發(fā)率最高。B組電離子加外用干擾素α-2b凝膠治療,復(fù)發(fā)率較單純電離子治療明顯降低。C組電離子、外用干擾素α-2b凝膠加用肌注干擾素α-2b注射液三聯(lián)療法復(fù)發(fā)率最低。AB兩組間的治愈率比較,單純使用電離子治療尖銳濕疣,治愈率低于電離子加外用干擾素α-2b凝膠治療。X~2= 4.10 P=0.04 ,P0.05,AB兩組間的治愈率的差異具有統(tǒng)計學(xué)意義。AC兩組間的治愈率比較,單純使用電離子治療尖銳濕疣,治愈率同樣低于電離子加外用干擾素α-2b凝膠治療加肌注干擾素α-2b注射液三聯(lián)療法的C組,X~2= 19.66 P=0.01,P0.05。AC兩組間的治愈率的差異具有統(tǒng)計學(xué)意義。BC兩組間的治愈率比較,C組電離子、外用干擾素α-2b凝膠加肌注干擾素α-2b注射液三聯(lián)療法治愈率高于電離子加外用干擾素α-2b凝膠治療。X~2= 3.88 P=0.04 ,P0.05,BC兩組間的治愈率的差異具有統(tǒng)計學(xué)意義。三組的治愈率由高到低為CBA, X~2= 23.23,P=0.01 ,P0.05,ABC三組間的治愈率差異具有統(tǒng)計學(xué)意義,C組的治愈率最高。電離子治療后,肌注干擾素α-2b注射液聯(lián)合外用干擾素α-2b凝膠三聯(lián)治療方法,在治療尖銳濕疣對比電離子聯(lián)合外用干擾素α-2b凝膠和對比單純電離子治療均有明顯的高治愈率和低復(fù)發(fā)率,該差異均有顯著統(tǒng)計學(xué)意義。 結(jié)論:多功能電離子聯(lián)合干擾素凝膠外用、干擾素α-2b注射液肌注三聯(lián)治療方法治療尖銳濕疣復(fù)發(fā)率低。在尖銳濕疣治療中療效確切,可顯著提高治愈率和減少尖銳濕疣復(fù)發(fā)率,與此同時其經(jīng)濟實用、操作簡便,值得臨床推廣。
[Abstract]:Objective: to observe and compare the efficacy of three methods in treating condyloma acuminatum and to explore the clinical effect of combined treatment of condyloma acuminatum. Methods: from December 2008 to November 2010, 76 patients with condyloma acuminatum, aged 18-55 years, who were admitted to the Department of Dermatology, second affiliated Hospital, Dalian Medical University, were retrospectively collected. 76 cases of condyloma acuminatum were randomly divided into 3 groups: group A (n = 20), group B (n = 21) and group C (n = 35). Prior to treatment, we understood in detail the basic condition of the patient and the related situation of the disease, and in the course of treatment and observation, The healing of skin lesions was recorded by the same observer. Group A was treated with simple multifunctional electric ion therapy machine and group B was treated with multifunctional electric ion therapy machine. Interferon 偽 -2b gel was applied to the affected area for three times a day for 8 weeks. Group C was intramuscularly injected with interferon 偽 -2b injection 1 million IUU on the basis of group B for 8 weeks, three times a week for 4 weeks as a course of treatment, and two consecutive courses of treatment. The times and methods of interferon gel were the same in group C for 8 weeks. After 6 months, the changes of skin lesions were observed and the adverse reactions were recorded. The curative effect and recurrence rate of condyloma acuminatum were compared among the three groups. The statistical data were processed by SPSS17.0 software. The data obtained were counted data, and the P value was 0.05 by chi-square test. The difference was statistically significant. Results: the cure rates of the three groups were 35.0% and 94.3%, respectively. The recurrence rates were 6528.6% and 5.7.A, respectively. The electric ions were used to treat condyloma acuminatum. The recurrence rate was the highest in group B and treated with interferon 偽 -2b gel. The recurrence rate of group C was significantly lower than that of group C. the relapse rate of group A was the lowest in combination of interferon 偽 -2b gel and intramuscular injection of interferon 偽 -2b injection. The cure rate of group A was lower than that of group B, and only electric ion was used to treat condyloma acuminatum. The cure rate was lower than that of electric ion plus interferon 偽 -2b gel. Xn2 = 4.10 P0. 04 and P0. 05% AB. The difference of cure rate between the two groups was statistically significant. The cure rate of AC group was higher than that of the other two groups, and only electric ion was used to treat condyloma acuminatum. The cure rate of group C was lower than that of group C treated by electroion plus interferon 偽 -2b gel plus intramuscular injection of interferon 偽 -2b injection. The difference of cure rate between group C and group C was statistically significant. The cure rate of group BC was higher than that of group C. The cure rate of interferon 偽 -2b gel combined with intramuscular interferon 偽 -2b injection was higher than that of electric ion plus interferon 偽 -2b gel. The cure rate of the three groups was from high to low to CBA. The difference of cure rate among the three groups was statistically significant. The cure rate of group C was the highest. After electroion therapy, interferon 偽 -2b injection was injected intramuscularly in combination with interferon 偽 -2b gel. In the treatment of condyloma acuminatum, electric ion combined with interferon 偽 -2b gel and electric ion therapy alone had obvious high cure rate and low recurrence rate, and the difference was statistically significant. Conclusion: multifunctional electroion combined with interferon gel is effective in the treatment of condyloma acuminatum. It is effective in the treatment of condyloma acuminatum. It can significantly improve the cure rate and reduce the recurrence rate of condyloma acuminatum. At the same time, it is economical and practical, simple to operate, and worthy of clinical popularization.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2011
【分類號】：R752.53

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