本文選題：光動(dòng)力 + 基底細(xì)胞癌��； 參考：《寧夏醫(yī)科大學(xué)》2011年碩士論文

【摘要】：目的探討光動(dòng)力療法(5-aminolevulinic acid-photodynamic therapy,ALA-PDT)治療BCC及SCC臨床療效、安全性及復(fù)發(fā)率。 方法臨床治療前后療效觀察,對(duì)于癌腫較大或浸潤(rùn)較深者每次治療前先行液氮冷凍,療程為4-8周。末次治療后進(jìn)行療效評(píng)價(jià),分別于治療后3、6、12和24月觀察復(fù)發(fā)率,同時(shí)觀察不良反應(yīng)。 結(jié)果36例患者中19例完全有效,治愈率為52.8%,包括14例淺表型BCC和5例結(jié)節(jié)型BCC。部分緩解為25.0%,總有效率為86.1%,無(wú)效率為13.9%。仍在隨訪中,目前暫未發(fā)現(xiàn)復(fù)發(fā)患者。 結(jié)論外用ALA-PDT方法治療BCC及SCC療效存在差異。對(duì)淺表型BCC治愈率高,結(jié)節(jié)型BCC有效,但治愈率偏低,建議顏面等特殊部位且較小者,有美容要求或不能耐受手術(shù)的患者臨床上可作為首選治療方案。對(duì)于較大腫瘤不易手術(shù)切除患者可作為術(shù)前準(zhǔn)備治療。但對(duì)SCC療效欠佳,尚需進(jìn)一步臨床觀察療效。
[Abstract]:Objective to investigate the efficacy, safety and recurrence rate of 5-aminolevulinic acid-photodynamic therapy in the treatment of BCC and SCC. Methods the therapeutic effect before and after treatment was observed. The patients with large cancer or deep infiltration were frozen with liquid nitrogen before each treatment. The course of treatment was 4-8 weeks. The curative effect was evaluated after the last treatment. The recurrence rate was observed at 12 and 24 months after treatment and the adverse reactions were observed at the same time. Results among the 36 patients, 19 cases were completely effective, the cure rate was 52.8%, including 14 cases of superficial BCC and 5 cases of nodular BCC. The total effective rate was 86.1, and the inefficiency was 13.9. Still in follow-up, at present, no recurrence has been found. Conclusion there are differences in the efficacy of ALA-PDT in the treatment of BCC and SCC. The cure rate of superficial BCC is high, the nodular BCC is effective, but the cure rate is low. It is suggested that the patients with special position and small face, who have cosmetic requirements or can not tolerate surgery can be regarded as the first choice in clinic. For patients with large tumors who are not easily resected surgically, it can be used as preparation for treatment before operation. However, the efficacy of SCC is not good, and further clinical observation is needed.
【學(xué)位授予單位】：寧夏醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R739.5

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