本文選題：無創(chuàng)性 + 生物力學(xué)　； 參考：《安徽醫(yī)科大學(xué)》2017年碩士論文

【摘要】：研究背景皮膚生物力學(xué)性能的重要特征是皮膚彈性性能,它的大小由皮膚膠原纖維彈力纖維及其數(shù)量和排列關(guān)系決定。面部皮膚的彈性是皮膚老化的重要指標(biāo)。近年國(guó)外皮膚彈性的研究文獻(xiàn)較多,以往活體皮膚彈性測(cè)量多針對(duì)相對(duì)非曝光部位進(jìn)行。近十年來,皮膚彈性的測(cè)量得到了很大的發(fā)展,在體測(cè)量部位有所增加,并出現(xiàn)了一些新的測(cè)量技術(shù)。這些技術(shù)的原理多基于張力,牽引力、扭力和吸力等,基于吸力原理的測(cè)試儀使用較廣泛。利用這種測(cè)試儀可以研究皮膚的光老化和彈性的關(guān)系,還可以研究在生理和病理狀況下皮膚彈性的變化規(guī)律。Germany CK公司的儀器正是依據(jù)負(fù)壓吸力設(shè)計(jì)的,負(fù)壓吸力和皮膚形變是這種設(shè)備的測(cè)試原理。將皮膚吸進(jìn)探頭的孔徑里,一段時(shí)間后再釋放。被吸進(jìn)探頭內(nèi)的皮膚深度是由一個(gè)光學(xué)檢測(cè)體系獲得,這種系統(tǒng)是彼此非接觸的。探頭內(nèi)有發(fā)光器和收光器和彼此相對(duì)的棱鏡構(gòu)成,皮膚的深度與發(fā)出光和收到光的比值具有正比關(guān)系,在測(cè)量過程中皮膚抵抗負(fù)壓(緊實(shí))以及回到原來狀態(tài)的能力(彈性)用曲線顯示出來(拉伸長(zhǎng)度/時(shí)間)。Cutometer MPA 580測(cè)試程序簡(jiǎn)便迅速,得到的彈性參數(shù)不受皮膚厚度大小的影響,是用來研究皮膚生理性老化和光老化的較好指標(biāo)。研究目的本研究旨在通過對(duì)不同年齡的中國(guó)漢族健康人群的無創(chuàng)性皮膚彈性測(cè)試,分析其與年齡和部位的相關(guān)性,并了解健康人群的皮膚彈性水平,探討影響皮膚彈性的因素,為其提供有效的預(yù)防措施。實(shí)驗(yàn)材料與方法用德國(guó)CK公司生產(chǎn)的MPA580無創(chuàng)性皮膚彈性測(cè)試儀檢測(cè)669例中國(guó)漢族健康志愿者(年齡范圍在3-70歲,平均年齡=30.96歲),分別測(cè)試前額、左眼角鼻尖、左鼻唇溝、左頸部、左前臂屈側(cè)、臍下、左脛前皮膚彈性。結(jié)果非暴露部位皮膚彈性相對(duì)于面部暴露部位高;參數(shù)R1、R4、R9與年齡呈正相關(guān);彈性總量R2、凈彈性量R5、彈性比值R7與年齡呈負(fù)相關(guān),眼角部位下降最明顯,30歲以后下降加快。眼角、鼻唇溝、頸前區(qū)、前臂屈側(cè)R9值隨年齡明顯增長(zhǎng),頸部R7與年齡的相關(guān)性最高,相關(guān)系數(shù)為0.706。結(jié)論本研究首次通過對(duì)大樣本的健康漢族人群的皮膚彈性測(cè)試,建立中國(guó)健康漢族人群皮膚彈性數(shù)據(jù)庫,為病理狀態(tài)下皮膚彈性變化情況提供一個(gè)對(duì)照平臺(tái),對(duì)皮膚病的預(yù)防、診斷和療效評(píng)估提供基礎(chǔ)。為影響皮膚彈性水平的因素提供了依據(jù),而且找到了在體無創(chuàng)性評(píng)價(jià)皮膚老化程度的簡(jiǎn)單有效方法,即通過與年齡相關(guān)性最高的頸部R7值(彈性比值)(|r|=0.706)的測(cè)量,利用線性回歸方程來量化皮膚老化程度,及估算皮膚年齡。
[Abstract]:Background the important feature of skin biomechanical properties is skin elasticity, which is made up of collagen fibers. Elastic fibers and their quantity and arrangement are determined. The elasticity of facial skin is an important index of skin aging. In recent years, there have been many researches on skin elasticity in foreign countries. In the past, the measurement of skin elasticity in vivo was mostly carried out on the relatively unexposed site. In the last ten years, the measurement of skin elasticity has been greatly developed, and some new measuring techniques have appeared. The principles of these techniques are based on tension, traction, torsion and suction. This instrument can be used to study the relationship between photoaging and elasticity of skin, as well as the regularity of skin elasticity in physiological and pathological conditions. The instrument of Germany CK Company is designed on the basis of negative suction. Negative suction and skin deformation are the testing principles of this equipment. Suck the skin into the aperture of the probe and release it after a while. The depth of skin absorbed into the probe is obtained by an optical detection system that is non-contact with each other. The probe is composed of a luminator and a light collector and a relative prism. The depth of the skin is proportional to the ratio of the light emitted to the light received. The ability of skin to resist negative pressure (compaction) and to return to its original state (elasticity) was shown by the curve during the measurement. (the test program of stretch length / time, Cutometer MPA 580 was simple and rapid, and the obtained elastic parameters were not affected by the thickness of skin. It is a good index for studying physiologic aging and photoaging of skin. Objective the purpose of this study was to analyze the correlation between noninvasive skin elasticity and age and site of healthy Chinese Han people of different ages, and to explore the factors influencing skin elasticity. To provide effective preventive measures. Materials and methods 669 healthy Chinese Han nationality volunteers (aged 3-70 years, mean age 30.96 years) were tested by MPA580 non-invasive skin elasticity tester made by CK Company in Germany. The forehead, left eye angle and nasal tip, left nasolabial sulcus were measured respectively. Left neck, left forearm flexion, subumbilical, left tibial anterior skin elastic. Results the skin elasticity of the non-exposed area was higher than that of the face exposed site, the parameter R _ (1) C _ (4) C _ (4) C _ (9) was positively correlated with the age, the total elasticity R _ (2), the net elastic value (R _ 5) and the elastic ratio (R _ 7) were negatively correlated with the age, and the decrease of the corner of the eye was more obvious after 30 years. The R9 value of eye angle, nasolabial sulcus, anterior cervical area and forearm flexion increased significantly with age, and the correlation coefficient between neck R7 and age was the highest, the correlation coefficient was 0.706. Conclusion for the first time, the skin elasticity database of healthy Han population in China was established by testing the skin elasticity of a large sample of healthy Han population, which provided a control platform for the change of skin elasticity in pathological condition and the prevention of dermatosis. Diagnosis and evaluation of efficacy provide the basis. It provides the basis for influencing the factors of skin elasticity level, and finds a simple and effective method to evaluate the skin aging degree in vivo, that is, by measuring the cervical R7 value (r = 0.706), which has the highest correlation with age. Linear regression equation was used to quantify skin aging and to estimate skin age.
【學(xué)位授予單位】：安徽醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R751

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