本文選題：鱗狀細(xì)胞癌 + HIF-1α�。� 參考：《青島大學(xué)》2012年碩士論文

【摘要】：目的研究缺氧誘導(dǎo)因子-1α(HIF-1α)、基質(zhì)金屬蛋白酶-2(MMP-2)在皮膚鱗癌中的表達(dá)及相關(guān)性。 方法應(yīng)用免疫組化法檢測(cè)42例皮膚鱗癌、13例BOWEN病、11例正常皮膚組織中HIF-1α、MMP-2的表達(dá)。 結(jié)果HIF-1α和MMP-2在正常皮膚組織、BOWEN病及皮膚鱗癌中的表達(dá)率為O%、61.54%、73.81%及0%、38.46%、50%,其差異有統(tǒng)計(jì)學(xué)意義(X2=23.675, P0.05;X2=12.955, P0.05).HIF-1α、MMP-2在皮膚鱗癌中的表達(dá)高于正常皮膚組織,差異有統(tǒng)計(jì)學(xué)意義(X2=16.638, P0.05; X2=7.139, P0.05).HIF-1α、 MMP-2在Bowen病中的表達(dá)高于正常皮膚組織,差異有統(tǒng)計(jì)學(xué)意義(P=0.02；P=0.041)。在皮膚鱗癌中HIF-1α與MMP-2的表達(dá)呈正相關(guān)性(rs=0.379,P0.05)。 結(jié)論HIF-1α、MMP-2在皮膚鱗癌中高度表達(dá),兩者在皮膚鱗癌中的表達(dá)具有密切相關(guān)性。
[Abstract]:Objective to study the expression and correlation of hypoxia inducible factor-1 偽 (HIF-1 偽) and matrix metalloproteinase-2 (MMP-2) in cutaneous squamous cell carcinoma (SCC). Methods Immunohistochemical method was used to detect the expression of HIF-1 偽 -MMP-2 in 13 cases of BOWEN's disease and 11 cases of normal skin tissue. Results the expression rates of HIF-1 偽 and MMP-2 in normal skin tissues were 61.54%, 73.81% and 38.4650%, respectively. The difference was statistically significant (P 0.05). The expression of P0.05).HIF-1 偽 MMP-2 in cutaneous squamous cell carcinoma was significantly higher than that in normal skin tissues, and the expression of P0.05).HIF-1 偽 MMP-2 in skin squamous cell carcinoma was significantly higher than that in normal skin tissues. The difference was statistically significant (P 0.05, P 0.05), and the expression of P0.05).HIF-1 偽 and MMP-2 in Bowen's disease was higher than that in normal skin tissue, and the difference was statistically significant (P < 0.05). There was a positive correlation between the expression of HIF-1 偽 and MMP-2 in cutaneous squamous cell carcinoma. Conclusion HIF-1 偽 -MMP-2 is highly expressed in cutaneous squamous cell carcinoma, and there is a close correlation between the expression of MMP-2 and HIF-1 偽 in cutaneous squamous cell carcinoma.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R739.5

【參考文獻(xiàn)】

相關(guān)期刊論文 前3條

1 吳強(qiáng),楊述華,王銳英,葉樹(shù)楠,夏天,馬德彰;干擾RNA沉默HIF-1α在缺氧狀態(tài)下對(duì)骨肉瘤細(xì)胞VEGF表達(dá)的影響[J];癌癥;2005年05期

2 李玉軍,李力,梁朝群,孫顯路,姜天福,紀(jì)祥瑞;低氧誘導(dǎo)因子-1α表達(dá)與胰腺癌增殖和凋亡的關(guān)系[J];青島大學(xué)醫(yī)學(xué)院學(xué)報(bào);2004年01期

3 高勇,王杰軍,王革芳,許青,郭靜;缺氧對(duì)腫瘤細(xì)胞產(chǎn)生和分泌基質(zhì)金屬蛋白酶的影響[J];癌癥;2005年02期

，

本文編號(hào)：1915552