本文選題：積雪苷 + 外敷　； 參考：《中國藥房》2017年02期

【摘要】：目的:觀察積雪苷外敷并口服聯(lián)合曲尼司特治療外傷瘢痕增生的臨床療效及安全性。方法:選取2014年12月-2015年12月邢臺市人民醫(yī)院皮膚科收治的外傷瘢痕增生患者126例,根據(jù)用藥方案的不同將其分為對照組和觀察組,各63例。兩組患者均給予曲尼司特膠囊,每次0.1 g,tid;觀察組患者在此基礎(chǔ)上外敷積雪苷霜軟膏適量,每天3~4次,并加服積雪苷片,每次12~24 mg,tid。兩組患者均治療8周。比較兩組患者臨床療效、1年內(nèi)復(fù)發(fā)率、平均用藥時間、癥狀消失時間、治療滿意度,以及不良反應(yīng)發(fā)生情況。結(jié)果:治療后,觀察組患者治療總有效率(93.65%)明顯高于對照組(77.78%),1年內(nèi)復(fù)發(fā)率(4.76%)明顯低于對照組(15.87%),差異均有統(tǒng)計學(xué)意義(P0.05);觀察組患者平均用藥時間和癥狀消失時間明顯短于對照組,治療滿意度明顯高于對照組,差異均有統(tǒng)計學(xué)意義(P0.05);觀察組患者不良反應(yīng)發(fā)生率(6.35%)明顯低于對照組(17.46%),差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:積雪苷外敷并口服聯(lián)合曲尼司特治療外傷瘢痕增生療效顯著,可降低患者瘢痕增生復(fù)發(fā)率,縮短其用藥時間和癥狀消失時間,且安全性較好。
[Abstract]:Objective: to observe the clinical efficacy and safety of topical application of snow glycoside combined with tranilast in the treatment of traumatic scar hyperplasia. Methods: 126 patients with traumatic scar hyperplasia admitted in Department of Dermatology of Xingtai people's Hospital from December 2014 to December 2015 were divided into control group (n = 63) and observation group (n = 63). The patients in both groups were given tranilast capsule 0.1 g / d each time, and the patients in the observation group were treated with a proper amount of snow glycoside cream on this basis, 3 times a day, 4 times a day, and added with snow glycoside tablet, 124mg / d each time. Both groups were treated for 8 weeks. The clinical efficacy, recurrence rate, average time of medication, time of symptom disappearance, treatment satisfaction and adverse reaction were compared between the two groups. Results: after treatment, the total effective rate of treatment in the observation group was significantly higher than that in the control group (77.78) and the recurrence rate within one year was 4.76) significantly lower than that in the control group (15.87g / kg), the difference was statistically significant (P 0.05), the average time of medication and symptom disappearance in the observation group was significantly shorter than that in the control group. The treatment satisfaction was significantly higher than that in the control group (P 0.05), and the incidence of adverse reactions in the observation group was 6.35%, which was significantly lower than that in the control group (P 0.05). Conclusion: the treatment of scar hyperplasia by external application of snow glycoside and oral combined with tranilast is effective, which can reduce the recurrence rate of scar hyperplasia, shorten the time of medication and the time of symptom disappearance, and the safety is good.
【作者單位】： 邢臺市人民醫(yī)院皮膚科;邢臺市人民醫(yī)院中醫(yī)外科;河北醫(yī)科大學(xué)第四醫(yī)院皮膚科;
【基金】：河北省衛(wèi)生廳科研基金項目(No.20150174)
【分類號】：R751.05

【相似文獻】

相關(guān)期刊論文 前10條

1 蔡金星;;積雪苷的臨床應(yīng)用[J];海峽藥學(xué);2007年09期

2 崔福W，

本文編號：1823720