發(fā)布時(shí)間：2018-04-15 17:15

  本文選題：白芍總苷 + 組胺受體拮抗劑　； 參考：《中國(guó)皮膚性病學(xué)雜志》2017年10期

【摘要】：目的評(píng)價(jià)三聯(lián)藥物方案治療慢性自發(fā)性蕁麻疹的臨床療效及安全性。方法將2014年4月-2016年4月本科診治的130例慢性自發(fā)性蕁麻疹患者采用隨機(jī)數(shù)字表法分為兩組,各65例。對(duì)照組予地氯雷他定聯(lián)合左西替利嗪,治療組予地氯雷他定聯(lián)合左西替利嗪及白芍總苷,療程均為8周。結(jié)果治療組近期療效顯著優(yōu)于對(duì)照組,治療組患者風(fēng)團(tuán)持續(xù)時(shí)間顯著短于對(duì)照組,治療組患者治療后UAS7評(píng)分顯著低于對(duì)照組和其治療前UAS7評(píng)分,治療組患者復(fù)發(fā)率顯著低于對(duì)照組,以上差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。但是兩組患者不良反應(yīng)發(fā)生率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論三聯(lián)藥物治療慢性自發(fā)性蕁麻疹可有效緩解患者的臨床癥狀和體征,降低遠(yuǎn)期復(fù)發(fā)風(fēng)險(xiǎn),且安全性好。
[Abstract]:Objective to evaluate the efficacy and safety of triple drug regimen in the treatment of chronic spontaneous urticaria.Methods 130 patients with chronic spontaneous urticaria from April 2014 to April 2016 were randomly divided into two groups, 65 cases in each group.The control group received desloratadine combined with levo-cetirizine, the treatment group received desloratadine combined with levocetirizine and total glucoside of paeony for 8 weeks.Results the short-term curative effect of the treatment group was significantly better than that of the control group. The duration of wind mass in the treatment group was significantly shorter than that in the control group. The UAS7 score of the treatment group was significantly lower than that of the control group and its UAS7 score before treatment.The recurrence rate in the treatment group was significantly lower than that in the control group, and the difference was statistically significant (P 0.05).However, there was no significant difference in the incidence of adverse reactions between the two groups (P 0.05).Conclusion Triple drug therapy for chronic spontaneous urticaria can effectively relieve the clinical symptoms and signs, reduce the long-term risk of recurrence, and the safety is good.
【作者單位】： 達(dá)州市中心醫(yī)院皮膚科;
【分類號(hào)】：R758.24

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