本文選題：銀屑病 + AIM��； 參考：《安徽醫(yī)科大學(xué)學(xué)報(bào)》2016年10期

【摘要】：目的探討AIM2基因多態(tài)性的遺傳模式與銀屑病表型的相關(guān)性。方法研究團(tuán)隊(duì)前期通過外顯子芯片研究表明AIM2(rs2276405)基因是中國漢族人尋常型銀屑病的易感基因之一,以此為基礎(chǔ),運(yùn)用PLINK 1.07和SPSS 20.0軟件對(duì)16 876例銀屑病患者和22 920例健康對(duì)照者的基因型-表型數(shù)據(jù)和各表型的遺傳模式進(jìn)行統(tǒng)計(jì)分析。結(jié)果基因型和等位基因分布結(jié)果顯示A為最小等位基因,G為風(fēng)險(xiǎn)基因。遺傳模式分析顯示顯性模式是AIM2基因多態(tài)性位點(diǎn)的最佳遺傳模式。與對(duì)照組比較,在顯性遺傳模式中PASI≤20(OR=0.83,P=1.10×10~(-7))的分布較PASI20(OR=0.91,P=3.62×10~(-1))更顯著,其次,家族史陰性(OR=0.82,P=6.85×10~(-8))較家族史陽性患者(OR=0.90,P=1.01×10~(-1))統(tǒng)計(jì)學(xué)差異更有顯著性。各表型在病例與對(duì)照之間比較差異無統(tǒng)計(jì)學(xué)意義。結(jié)論 AIM2(rs2276405)與中國漢族人尋常型銀屑病的發(fā)病有顯著相關(guān)性,在各亞型中顯性遺傳模式是尋常型銀屑病的最佳遺傳模式,可能與家族史陰性的輕中度尋常型銀屑病患者有關(guān),并因此可能導(dǎo)致尋常型銀屑病臨床表型的多樣性。
[Abstract]:Objective to investigate the association between AIM2 gene polymorphism and psoriasis phenotype.Methods the exon microarray study showed that the AIM2 rs2276405) gene was one of the susceptible genes for psoriasis vulgaris in Chinese Han people.Genotypic data and genetic patterns of 16 876 psoriasis patients and 22 920 healthy controls were analyzed by PLINK 1.07 and SPSS 20.0 software.Results the results of genotype and allele distribution showed that A was the least allele and G was a risk gene.Genetic pattern analysis showed that dominant pattern was the best genetic model for polymorphic loci of AIM2 gene.There was no significant difference in phenotypes between cases and controls.Conclusion AIM2 rs2276405) has a significant correlation with the incidence of psoriasis vulgaris in Chinese Han nationality. The dominant genetic pattern is the best genetic model of psoriasis vulgaris in all subtypes, and may be associated with mild to moderate psoriasis with negative family history.This may lead to phenotypic diversity in psoriasis vulgaris.
【作者單位】： 安徽醫(yī)科大學(xué)第一附屬醫(yī)院皮膚性病科;
【基金】：國家自然科學(xué)基金(編號(hào):81271747)
【分類號(hào)】：R758.63

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本文編號(hào)：1748845