本文選題：基底細(xì)胞乳頭狀瘤 + MMP-��； 參考：《中國(guó)腫瘤臨床》2014年16期

【摘要】：目的:研究基底細(xì)胞乳頭狀瘤(basal cell papilloma,BCP)患者曝光部位皮損、非曝光部位皮損以及正常皮膚組織中MMP-1和PTEN蛋白的表達(dá),探討B(tài)CP的發(fā)病與皮膚光老化之間的關(guān)系。方法:選取曝光部位皮損50例,非曝光部位皮損50例,正常皮膚30例。采用免疫組織化學(xué)Elivison法檢測(cè)各組MMP-1和PTEN蛋白的表達(dá)情況,比較各組間差異。選取曝光部位皮損90例,分為3組,分別為外用遮光劑二氧化鈦霜組、安慰劑組和未用藥組,用藥3個(gè)月后比較3組皮損MMP-1的表達(dá)。結(jié)果:曝光部位皮損MMP-1的表達(dá)評(píng)分較正常對(duì)照組顯著升高(P0.01),非曝光部位皮損MMP-1的表達(dá)評(píng)分與對(duì)照組無(wú)顯著性差異(P0.05)。曝光部位皮損和非曝光部位皮損PTEN蛋白的表達(dá)評(píng)分均較正常對(duì)照組顯著降低(P0.01)。3個(gè)月后,外用二氧化鈦霜組MMP-1的表達(dá)評(píng)分較未用藥組明顯降低(P0.05)。結(jié)論:MMP-1在曝光部位的BCP中呈現(xiàn)高表達(dá)。PTEN蛋白在曝光部位和非曝光部位的BCP中呈現(xiàn)低表達(dá)。紫外線照射導(dǎo)致的皮膚光老化可能是曝光部位BCP發(fā)生的一個(gè)誘發(fā)因素。
[Abstract]:Objective: to study the expression of MMP-1 and PTEN protein in the exposed and unexposed lesions of basal cell cell papillomonas papillomata (BCP) patients, and to explore the relationship between the pathogenesis of BCP and skin photoaging.Methods: 50 cases of exposure lesions, 50 cases of non-exposure lesions and 30 cases of normal skin were selected.Immunohistochemical Elivison method was used to detect the expression of MMP-1 and PTEN protein in each group.90 cases of skin lesions at exposure site were divided into 3 groups: external shading group, placebo group and untreated group. The expression of MMP-1 in skin lesions of 3 groups was compared after 3 months of treatment.Results: the expression score of MMP-1 in skin lesions at exposure site was significantly higher than that in normal control group (P 0.01), but there was no significant difference in MMP-1 expression score between exposure site and control group (P 0.05).The expression of PTEN protein in the exposed and unexposed lesions was significantly lower than that in the control group (P 0.01). After 3 months, the expression of MMP-1 in the titanium dioxide cream group was significantly lower than that in the untreated group.Conclusion the high expression of MMP 1 in exposed BCP and the low expression of PTEN protein in BCP of exposure site and non exposure site were observed.UV-induced skin photoaging may be a predisposing factor for BCP at exposure site.
【作者單位】： 天津市公安醫(yī)院皮膚科;
【分類號(hào)】：R739.5
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本文編號(hào)：1739704