本文選題：麻風(fēng)病　切入點(diǎn)：IL-　出處：《中國免疫學(xué)雜志》2014年08期

【摘要】：目的:通過檢測麻風(fēng)病患者血清IL-10及外周血CD4+CD25+Foxp3+調(diào)節(jié)性T細(xì)胞(Treg)的水平,分析它們相互間的關(guān)系,探討IL-10及調(diào)節(jié)性T細(xì)胞引起麻風(fēng)患者免疫功能異常的機(jī)制。方法:用流式細(xì)胞微球芯片捕獲技術(shù)(CBA)檢測30例麻風(fēng)患者及25例正常對(duì)照血清IL-10的濃度;用流式細(xì)胞儀檢測51例麻風(fēng)患者及56例正常對(duì)照外周血Treg細(xì)胞的水平。結(jié)果:麻風(fēng)患者血清IL-10濃度(130.00±54.27)pg/ml比對(duì)照組(15.64±7.11)pg/ml高(P0.05);外周血Treg細(xì)胞水平(17.626±8.1977)%比對(duì)照組(9.998±1.7062)%高(P0.05);麻風(fēng)患者治愈后血清IL-10的濃度與外周血Treg細(xì)胞水平呈正相關(guān)線性關(guān)系(P0.05)。結(jié)論:IL-10及Treg細(xì)胞的調(diào)控失衡可能是引起麻風(fēng)發(fā)病的原因之一。
[Abstract]:Aim: to investigate the relationship between serum IL-10 and peripheral blood CD4 CD25 Foxp3 regulatory T cell regs in leprosy patients, and to explore the mechanism of IL-10 and regulatory T cells inducing immune dysfunction in leprosy patients.Methods: the levels of serum IL-10 in 30 leprosy patients and 25 normal controls were detected by flow cytometry microsphere capture technique, and the levels of Treg cells in peripheral blood of 51 leprosy patients and 56 normal controls were detected by flow cytometry.緇撴灉:楹婚鎮(zhèn)ｈ，

本文編號(hào)：1713421