發(fā)布時間：2018-03-24 12:15

  本文選題：惡性淋巴瘤　切入點：帶狀皰疹　出處：《中華醫(yī)院感染學雜志》2014年17期

【摘要】：目的探討惡性淋巴瘤患者化療后繼發(fā)帶狀皰疹的危險因素,指導臨床預防與控制醫(yī)院感染的發(fā)生。方法選取2002年1月-2012年10月血液科住院的123例惡性淋巴瘤患者,其中發(fā)生帶狀皰疹患者51例作為病例組,無帶狀皰疹的患者72例,作為對照組,采用病例對照研究方法對惡性淋巴瘤后帶狀皰疹患者進行分析,先將研究變量做單因素分析,再將有意義的變量進行多因素非條件logistic同歸分析。結(jié)果帶狀皰疹患者的發(fā)病部位以胸肋神經(jīng)區(qū)和腰腹神經(jīng)區(qū)為主,分別占56.86%和27.45%;帶狀皰疹患者的臨床類型以尋常型為主,占86.27%;單因素分析顯示,Ann Arbor分期(Ⅲ、Ⅳ期)、B癥狀、初診時原因不明的發(fā)熱(38℃)、惡性淋巴瘤未緩解狀態(tài)與惡性淋巴瘤患者帶狀皰疹發(fā)病顯著相關(guān)(P0.01),而惡性淋巴瘤達緩解狀態(tài)是具有統(tǒng)計學意義的保護因素(P0.01);進一步行多因素logistic回歸分析,惡性淋巴瘤達緩解狀態(tài)(OR=0.091)、Ann Arbor分期(Ⅰ、Ⅱ期)(OR=0.089)、A癥狀(OR=0.065)與惡性淋巴瘤患者帶狀皰疹發(fā)病呈負相關(guān)(P0.05)。結(jié)論醫(yī)師應(yīng)關(guān)注惡性淋巴瘤患者發(fā)生帶狀皰疹的危險因素,早期給予積極治療。
[Abstract]:Objective to investigate the risk factors of secondary herpes zoster after chemotherapy in patients with malignant lymphoma and to guide clinical prevention and control of nosocomial infection. Methods 123 patients with malignant lymphoma were selected from January 2002 to October 2012. Among them, 51 cases of patients with herpes zoster as case group and 72 cases of patients without herpes zoster as control group were used to analyze the patients with herpes zoster after malignant lymphoma by case-control study. Results the main sites of herpes zoster patients were thoracic costal nerve region and lumbar abdominal nerve area, accounting for 56.86% and 27.45%, respectively, and the clinical types of herpes zoster patients were mainly vulgaris. Univariate analysis showed that Ann Arbor stage (鈪，

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