本文選題：慢性光化性皮炎　切入點(diǎn)：最小紅斑量　出處：《昆明醫(yī)科大學(xué)》2012年碩士論文

【摘要】：目的利用云南地區(qū)慢性光化性皮炎(chronic actinic dermatitis, CAD)發(fā)病率高的優(yōu)勢(shì),對(duì)云南地區(qū)CAD患者和正常人的最小紅斑量和光斑貼試驗(yàn)的差異進(jìn)行測(cè)定和分析,并探討IL-6、TNF-a與CAD患者發(fā)病的相關(guān)性。 方法采用SUV1000型日光模擬器對(duì)21例CAD患者和40例正常對(duì)照者進(jìn)行最小紅斑量的測(cè)定,并采用SS-03AB型紫外線光療儀和標(biāo)準(zhǔn)光斑貼試驗(yàn)試劑盒對(duì)21例CAD患者和21例正常對(duì)照者進(jìn)行光斑貼試驗(yàn)(光源：UVA5J/cm2)應(yīng)用ELISA的方法檢測(cè)CAD患者、正常對(duì)照者血清中IL-6、TNF-a的含量。應(yīng)用SPSS17.0軟件對(duì)數(shù)據(jù)資料進(jìn)行統(tǒng)計(jì)分析。 結(jié)果1、CAD患者組的UVA-MED、UVB-MED分別為26.05J/cm2、28.32mJ/cm2;正常對(duì)照組的UVA-MED、UVB-MED分別為50.06J/cm2、38.25mJ/cm2. CAD患者的UVA-MED、UVB-MED較正常人對(duì)照組明顯降低,P值均0.05。正常對(duì)照組內(nèi)UVA-MED和UVB-MED兩性間差異無統(tǒng)計(jì)學(xué)意義,P均0.05。2、CAD患者、正常人中光斑貼試驗(yàn)陽性率分別為57.1%,47.6%。CAD患者最常見的光變應(yīng)原為芳香混合物(31.25%)、D-松蘿酸(12.50%)和木材合成物(12.50%)；正常人最常見的光變應(yīng)原為芳香混合物(23.08%)、D-松蘿酸(15.38%)、秘魯香脂(15.38%)。經(jīng)檢驗(yàn)CAD患者與正常人對(duì)照組的光斑貼試驗(yàn)結(jié)果差異無統(tǒng)計(jì)學(xué)意義(P0.05)。3、IL-6在CAD患者組血清中為0.953±0.198(pg/ml),低于正常人血清中(3.165±0.772pg/ml)的水平,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。CAD患者組血清中TNF-a和正常人對(duì)照組血清水平無明顯差異,無統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論1、最小紅斑量的測(cè)定提示CAD的發(fā)病與UVA、UVB的照射有關(guān),其中UVA更為敏感。2、CAD患者及正常人對(duì)照組都對(duì)多種(光)接觸性變應(yīng)原呈陽性反應(yīng)。 3、CAD的發(fā)病可能和IL-6的降低有一定的關(guān)系。
[Abstract]:Objective to measure and analyze the difference of minimal erythema amount and light spot patch test between CAD patients and normal subjects in Yunnan province by using the high incidence rate of chronic actinic dermatitis (CAD), and to explore the correlation between IL-6 actinic TNF-a and the incidence of CAD. Methods the minimal erythema was measured in 21 patients with CAD and 40 normal controls by using SUV1000 solar simulator. Using SS-03AB ultraviolet phototherapy instrument and standard spot patch test kit, 21 CAD patients and 21 normal control subjects were tested by ELISA with the light source of: UVA 5J / cm 2. The contents of IL-6 and TNF-a in serum of normal controls were analyzed by SPSS17.0 software. Results 1 the UVA-MED- UVB-MED was 26.05J / cm ~ (-2) (28.32mJ / cm ~ (-2)) in CAD group and 50.06J / cm ~ (-2) UVB-MED was 58.25mJ / cm ~ (2) in normal control group. The value of UVA-MEDUVB-MED in CAD patients was significantly lower than that in normal control group (0.05). There was no significant difference between UVA-MED and UVB-MED in normal control group (P < 0.05). The most common photoallergens in CAD patients were the aromatic mixture of 31. 25% D- arboxylic acid 12.50) and wood compound 12. 50%, respectively. The most common photoallergens in normal people were the aromatic mixture of 23. 08D-pinealic acid 15.38%, Peruvian balsamic acid 15. 38%. There was no significant difference in the results of spot patch test between CAD patients and normal controls. The serum level of IL-6 in CAD patients was 0.953 鹵0.198 mg / ml, which was lower than that in normal controls (3.165 鹵0.772 PG / ml). There was no significant difference in serum levels of TNF-a between the patients with P0.05 and the control group, and there was no significant difference in the serum levels between the two groups. Conclusion 1. The determination of minimal erythema quantity indicates that the pathogenesis of CAD is related to the exposure to UVB, and UVA is more sensitive to UVA and normal control group is positive for many (light) contact allergens. 3 the incidence of IL-6 may be related to the decrease of IL-6.
【學(xué)位授予單位】：昆明醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類號(hào)】：R758.14

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王向東;;沙利度胺片治療慢性光化性皮炎療效觀察[J];華中醫(yī)學(xué)雜志;2007年05期

2 陳浩,鄧丹琪;慢性光化性皮炎[J];臨床皮膚科雜志;2004年02期

3 陳浩,鄧丹琪,周曉鴻,樊應(yīng)俊;慢性光化性皮炎凋亡蛋白表達(dá)的檢測(cè)[J];臨床皮膚科雜志;2005年08期

4 農(nóng)祥;何黎;付蘭;;羥基氯喹治療慢性光線性皮炎臨床療效觀察[J];臨床皮膚科雜志;2007年08期

5 嚴(yán)慧;鄧丹琪;王金煥;蘇偉婷;樊應(yīng)俊;;蒿甲醚對(duì)紫外線照射后HaCaT細(xì)胞表達(dá)Fas和Bcl-2的影響[J];臨床皮膚科雜志;2008年07期

6 周曉鴻,冒長(zhǎng)峙,危群,李學(xué)平,張曉紅;慢性光化性皮炎真皮浸潤(rùn)細(xì)胞免疫表型及角朊細(xì)胞Fas抗原的表達(dá)[J];中國(guó)麻風(fēng)皮膚病雜志;2000年01期

7 呂曉萍,于波,吳文育,童秋生,李放娟;慢性光化性皮炎43例臨床分析[J];中國(guó)麻風(fēng)皮膚病雜志;2004年01期

8 農(nóng)祥;何黎;高燕;付蘭;;慢性光化性皮炎62例臨床分析[J];中國(guó)麻風(fēng)皮膚病雜志;2007年11期

9 李秀麗;廖萬清;盧忠;;上海地區(qū)100例正常人紫外線最小紅斑值測(cè)定[J];中國(guó)麻風(fēng)皮膚病雜志;2008年05期

10 王曉彥;田華;朱秀蘭;烏日娜;;超氧化物歧化酶在慢性光化性皮炎中的表達(dá)[J];內(nèi)蒙古醫(yī)學(xué)雜志;2006年12期

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