本文選題：雄激素性禿發(fā)　切入點(diǎn)：代謝綜合征　出處：《浙江大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 目的：探討雄激素性脫發(fā)(androgenetic alopecia, AGA)男性患者多個(gè)可能相關(guān)因素的發(fā)生率,代謝綜合征(metabolic syndmme, MS)、良性前列腺增生(Benign prostatic hyperplasia, BPH)的發(fā)生率以及AGA與心血管病危險(xiǎn)因素間的關(guān)系。方法：選擇2001年1月至3月于浙江大學(xué)醫(yī)學(xué)院附屬第二醫(yī)院國際保健中心參加體檢的符合Norwood-Hamilton分級法I-VII級的63位男性為禿發(fā)組,其中選取符合Norwood-Hamilton分級法III V級及以上的頂禿患者43例,為頂禿組。依禿發(fā)組的年齡結(jié)構(gòu)在上述無禿頂?shù)捏w檢人員中隨機(jī)抽取64人,為對照組。收集AGA患者發(fā)病年齡、家族史、生活精神因素及疾病史等相關(guān)因素,并對其進(jìn)行分析。并且檢測所有人員體質(zhì)量指數(shù)(body mass index, BMI)、總膽固醇、甘油三酯、高密度脂蛋白膽固醇(high density lipopmtein cholesterol, HDL-C)、低密度脂蛋白膽固醇(low density lipopmtein cholesterol, HDL-C).血糖、血尿酸、肝膽B(tài)超及前列腺B超等指標(biāo),通過比較三組上述指標(biāo)的差異,分析AGA男性的MS、心血管病危險(xiǎn)因素的發(fā)生率及聚集性,及其間的相關(guān)性分析及BPH的發(fā)生率。 結(jié)果：(1)63例患者,平均年齡46.19土9.53歲,以40-60為主,大部分患者發(fā)病年齡為31-40歲。其中有34例(53.97%)患者的親屬中有AGA患者,以父親患病的患者例數(shù)最多,為22例占34.92%。20.24%的患者壓力較大。20.63%的患者嗜好油膩及高熱量飲食。36.51%的患者吸煙,34.92%的患者飲酒。15.87%的患者患有高血壓病,6.35%的患者患有糖尿病,3.17%的患者患有冠心病。63例患者臨床分級以ⅢⅤ級(15.87%)、Ⅳ級(14.29%)和V級(19.05%)為常見。(2)根據(jù)三組的檢測結(jié)果,發(fā)現(xiàn)禿發(fā)組的BMI為24.88±3.15Kg/m2,顯著高于對照組(23.81±2.87Kg／m2),差異有顯著性意義(P0.05)；而總膽固醇、甘油三酯、HDL-C.LDL-C.空腹血糖及血尿酸水平差異無顯著性意義(P0.05)。頂禿組的BMI為24.85±3.38Kg／m2,總膽固醇為190.02土30.50mg/dl,顯著高于對照組(23.81±2.87Kg／m2,179.67土31.97mg/dl),差異有顯著性意義(P0.05)；而甘油三酯、HDL-C.LDL-C.空腹血糖及血尿酸無水平差異無顯著性意義(P0.05)。(3)在過重、高血糖、血脂紊亂的危險(xiǎn)因素中,頂禿組的發(fā)生率為89.07%,高于禿發(fā)組的77.78%,而兩組均高于對照組的73.44%。(4)影像學(xué)檢查結(jié)果提示禿發(fā)組9.68%發(fā)現(xiàn)脂肪肝,30.65%發(fā)現(xiàn)肝內(nèi)脂質(zhì)沉積。頂禿組7.14%發(fā)現(xiàn)脂肪肝,30.95%發(fā)現(xiàn)肝內(nèi)脂質(zhì)沉積。兩組結(jié)果相對于對照組(脂肪肝17.46%,肝內(nèi)脂質(zhì)沉積23.81%)均無顯著性差異。禿發(fā)組BPH發(fā)生率為20.51%,頂禿組為12%,相對于對照組(17.24%)無顯著性差異。 結(jié)論：AGA多為中年發(fā)病,為與家族史、生活精神因素及疾病史有關(guān)的多因素疾病。AGA患者中頂禿患者M(jìn)S、心血管病各個(gè)危險(xiǎn)因素及前列腺增生發(fā)生率未明顯高于AGA群體。AGA與MS、心血管病有一定的關(guān)聯(lián)。AGA與BPH未發(fā)現(xiàn)明顯相關(guān)性。
[Abstract]:Objective: to investigate the incidence of multiple related factors in androgenetic alopecia (AGA) male patients with androgenetic alopecia. Metabolic syndrome: the incidence of benign prostatic hyperplasia (BPH) and the relationship between AGA and cardiovascular risk factors. Methods: from January 2001 to March, International Health Care, second affiliated Hospital, School of Medicine, Zhejiang University, China. A total of 63 men who were enrolled in the center's physical examination in accordance with the Norwood-Hamilton classification I-VII were alopecia. Among them, 43 patients with alopecia areata with III V grade and above according to Norwood-Hamilton classification were selected as the alopecia group. 64 patients were randomly selected as control group according to the age structure of the alopecia group. The onset age and family history of AGA patients were collected. Life and mental factors, disease history and other related factors were analyzed. Body mass index (BMI), BMI index, total cholesterol, triglyceride, etc. High density lipopmtein cholesterol (HDL-C), high density lipopmtein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), low density lipopmtein cholesterol (HDL-C), blood glucose, serum uric acid, liver and bile B ultrasound and prostate B ultrasound were compared between the three groups. The incidence and agglomeration of cardiovascular risk factors and their correlation with BPH were analyzed in male patients with AGA. Results the average age of 63 patients was 46.19 鹵9.53 years old, mainly 40-60 years old. The majority of the patients were 31-40 years old. Among them, 34 cases had AGA patients, and the father had the most cases. 22 patients with 34.922.20.24% patients with high pressure, 20.63% patients with greasy and high-calorie diet, 36.51% patients smoking, 34.92% patients with alcohol, 15.87% patients with hypertension, 6.35% patients with diabetes mellitus, 3.17% patients with coronary heart disease and 63 patients with coronary heart disease. According to the results of the three groups, clinical grade 鈪，

本文編號：1622141