本文選題：酒渣鼻　切入點(diǎn)：蠕形螨　出處：《蘭州大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 酒渣鼻是一種發(fā)生在顏面中部,以皮膚潮紅、毛細(xì)血管擴(kuò)張及丘疹、膿皰為表現(xiàn)的慢性皮膚病,發(fā)病機(jī)制尚不清楚。近年來研究表明蠕形螨的感染密度與酒渣鼻的發(fā)生有密切的關(guān)系。蠕形螨的感染與面部皮脂分泌量的多少有一定的關(guān)系,但缺乏一種對油脂分泌量客觀評估的方法。 目的：1.本研究旨在探討蠕形螨在酒渣鼻病因和發(fā)病機(jī)制中的作用,為酒渣鼻的治療提供更充分的科學(xué)依據(jù)；2.通過定量測試皮膚生理指標(biāo),檢測蠕形螨病患者皮膚油脂和pH,探討蠕形螨感染的酒渣鼻患者面部皮膚生理功能的特點(diǎn),以期指導(dǎo)治療和日常皮膚護(hù)理。 方法：選擇于2009年5月～2009年12月到蘭州大學(xué)第二醫(yī)院就診的酒渣鼻患者65例和正常對照組60例,采用擠壓法取材：采用粉刺擠壓器擠壓患者和健康者前額、鼻和下頜三個(gè)部位,刮取面積為1cm2,平均螨蟲感染密度取以上三個(gè)部位的平均值。取標(biāo)本(皮脂分泌物)于玻片上,以10%氫氧化鉀液制片,觀察到蟲體為陽性。面部皮膚生理指標(biāo)采用無創(chuàng)性皮膚生理指標(biāo)檢測儀分別對酒渣鼻患者和對照組面部的油脂和pH進(jìn)行測定。 結(jié)果：酒渣鼻患者面部蠕形螨的感染密度明顯高于正常對照組(P0.05)。丘疹膿皰期和鼻贅期螨蟲感染密度均高于紅斑期(均P0.05)；丘疹膿皰期的螨蟲感染密度與鼻贅期相比,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。面部感染蠕形螨酒渣鼻患者面部的油脂高于未感染蠕形螨的健康對照組(P0.05)；面部感染人蠕形螨酒渣鼻患者面部的酸堿度與未感染蠕形螨的健康對照組相比,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：面部蠕形螨感染可能是酒渣鼻的致病因素之一,面部皮膚油脂分泌過多是蠕形螨感染的易感因素。
[Abstract]:Rosacea is a central area of the face, the skin flushing, telangiectasia and papules, pustules, chronic skin disease manifestations, pathogenesis is still unclear. Recent studies show that the density of Demodex infection and rosacea are closely related to the occurrence of infection with Demodex. Facial sebum secretion somewhat the relationship, but the lack of a method for objective assessment of the oil secretion.
Objective: This study aimed to investigate the 1. Demodex mites in the etiology and pathogenesis of rosacea, provide more adequate scientific basis for the treatment of rosacea; 2. by quantitative measurement of skin physiology index, detection of demodicidosis were skin oils and pH, to explore the characteristics of rosacea patients with facial skin physiological function of Demodex infection, guide in the period of treatment and daily skin care.
Methods: from May 2009 to December 2009 to the Second Hospital Affiliated to Lanzhou University for treatment of rosacea patients 65 cases and 60 cases of normal control group, by using the method of extrusion: the acne squeezer patients and healthy forehead, nose and chin three parts, scraping area is 1cm2, the average density of infected mites average take the above three parts of the value. The specimens (sebaceous secretion) on a slide with 10% potassium hydroxide solution method, observed the body was positive. Facial skin physiological indexes by non-invasive skin physiology index tester respectively rosacea patients and controls facial oils and pH were measured.
Results: the density of infection in patients with rosacea Demodex was significantly higher than normal control group (P0.05). Papulopustule and rosacea mite infection density was higher than that in erythema stage (P0.05); papulopustule period mite infection density and rhinophyma period compared with no significant difference (P0.05) facial demodex infection in rosacea. The oil was higher than that of patients with facial demodex infection in healthy control group (P0.05); facial demodex infection in patients with rosacea facial pH and the healthy control group without demodex infection compared with no significant difference (P0.05).
Conclusion: may be one of the pathogenic factors of rosacea infection Demodex facial skin, excessive oil secretion is the predisposing factor of infection Demodex.

【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R758.734

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本文編號(hào)：1600640