本文選題：-氨基酮戊酸　切入點：光動力　出處：《中國皮膚性病學雜志》2014年09期 　論文類型：期刊論文

【摘要】：目的探討5-氨基酮戊酸光動力療法(ALA-PDT)治療宮頸內膜外移伴人類乳頭瘤病毒(HPV)亞臨床感染的療效。方法將68例宮頸內膜外移伴HPV亞臨床感染患者隨機分為兩組,每組34例。治療組完成1療程的ALA-PDT治療,共3次,每次間隔7~10d;對照組采用傳統(tǒng)的微波治療1次;隨訪3個月后判斷臨床療效,1年后比較HPV轉陰率。結果治療組34例經1療程治療后完全緩解率為73.53%(25/34);部分緩解率為26.47%(9/34)。對照組34例完全緩解率為88.24%(30/34);部分緩解率為11.76%(4/34)。治療組34例僅有輕度腹部墜脹及陰道分泌物稍增多,未出現陰道出血及宮頸疤痕。微波對照組34例均出現陰道排液、出血,4例宮頸疤痕。隨訪1年后治療組HPV轉陰率88.24%;對照組HPV轉陰率32.35%。ALA-PDT與傳統(tǒng)的微波治療相比,完全緩解率差異無統(tǒng)計學意義(P=0.12);HPV轉陰率差異有統(tǒng)計學意義(P0.01)。結論 ALA-PDT治療宮頸內膜外移伴HPV亞臨床感染,副作用少,療效可靠。
[Abstract]:Objective to investigate the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of subclinical infection of cervical endometrium with human papillomavirus (HPV). Methods Sixty-eight patients with HPV subclinical infection were randomly divided into two groups. 34 cases in each group. The treatment group completed a course of ALA-PDT treatment for 3 times, every time at intervals of 7: 10 days, while the control group was treated with traditional microwave therapy once; Results after one course of treatment, the complete remission rate of 34 cases in the treatment group was 73.53 / 34 / 34, the partial remission rate was 26.47% / 34 / 34, the complete remission rate in the control group was 88.24% 30 / 34% and the partial remission rate was 11.76 4 / 34%. In the treatment group, 34 cases had only slight abdominal bloating and a slight increase in vaginal secretion. There was no vaginal bleeding or cervical scar. Vaginal effusion was found in 34 cases and cervix scar in 4 cases in microwave control group. After one year follow-up, the negative rate of HPV in treatment group was 88.240.The negative rate of HPV in control group was 32.35%. ALA-PDT was compared with traditional microwave therapy. There was no significant difference in complete remission rate (P < 0.01). Conclusion ALA-PDT has less side effect and reliable curative effect in the treatment of cervical endometrium with subclinical infection of HPV.
【作者單位】： 佛山市婦幼保健院;廣州醫(yī)科大學附屬第三醫(yī)院;
【基金】：佛山市衛(wèi)生局科研項目(2013160) 廣東省自然科學基金項目(S2012040006869) 廣東省醫(yī)學科研基金項目(廣東省衛(wèi)生廳A2012273) 廣州市科技計劃項目(穗科信字[2013]166號,2013J4100102)
【分類號】：R752.53

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本文編號：1596048