本文選題：THz-TDS技術(shù)　切入點：透射式　出處：《天津大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】：近年來,隨著太赫茲時域光譜(THz-TDS)技術(shù)的發(fā)展,該技術(shù)在醫(yī)療診斷領(lǐng)域的研究得到更廣闊的應(yīng)用。由于生物大分子的振動能級大多數(shù)都處于THz波段,因此,THz-TDS技術(shù)能夠用來研究生物組織的信息,有望成為研究生物組織的有效手段,并在分子水平上揭示癌變組織的一些特征。這種新型的光譜技術(shù)除自身具有一些獨特的優(yōu)越性外,在醫(yī)學(xué)診斷上與傅里葉紅外光譜法之間存在一定的相近性。與傳統(tǒng)的病理學(xué)診斷相比,THz-TDS技術(shù)在醫(yī)學(xué)領(lǐng)域的發(fā)展可能提供快速無損的診斷結(jié)果,而且對癌變組織的前期診斷具有更高的敏感性。 本文簡要闡述了太赫茲時域光譜技術(shù)的原理與應(yīng)用潛力,著重介紹了該技術(shù)在醫(yī)療診斷領(lǐng)域的研究工作。對實驗室的THz-TDS系統(tǒng)進(jìn)行改進(jìn):將原有的手動掃描成像系統(tǒng)改為電機(jī)自動控制的掃描系統(tǒng),重新設(shè)計加工了二維平移臺的機(jī)械結(jié)構(gòu)。利用透射式太赫茲時域光譜技術(shù)獲取人體正常皮膚組織和癌變組織的THz時域光譜,并對得到THz譜線進(jìn)行分析。首先對實驗得到透過樣品的THz時域信號的數(shù)據(jù)成像描繪出樣品的輪廓以及產(chǎn)生病變組織的大致區(qū)域;再經(jīng)過傅立葉變換得到頻域信號,進(jìn)一步計算得出樣品多個測量點對THz的吸收曲線,通過觀察這些曲線得出在1.35THz、1.65THz和2.2THz處樣品的吸收峰最為明顯。利用這三個敏感吸收峰的數(shù)據(jù)分別對樣品成像,結(jié)果顯示在1.35THz和1.65THz處皮膚組織中癌變成分對THz吸收明顯。成像結(jié)果中吸收強(qiáng)烈的部位接近于病理診斷的癌變部位,而在2.2THz處的成像中這一位置與病理診斷的位置相差很大。結(jié)果表明在皮膚組織診斷中THz的頻段應(yīng)控制在2.2THz以下的低頻范圍。 通過對比研究正常皮膚組織和癌變組織的太赫茲光譜發(fā)現(xiàn),正常皮膚組織與癌變組織的THz譜線表現(xiàn)出很大的差異性。對于這種結(jié)果有學(xué)者分析是水對THz的吸收比較強(qiáng)烈,而癌變組織與健康組織相比,由于營養(yǎng)成分更豐富,含水量也較高。因此,在吸收特性上二者存在差異。而本文認(rèn)為差異還應(yīng)該來源于癌變組織中成分變化帶來綜合的影響。研究顯示THz-TDS技術(shù)在生物醫(yī)學(xué)上診斷的可行性。
[Abstract]:In recent years, with the development of terahertz time-domain spectroscopy (THz) technique, this technique has been widely used in the field of medical diagnosis. Most of the vibrational energy levels of biomolecules are in the THz band. Therefore, THz-TDS technology can be used to study the information of biological tissue, and it is expected to be an effective means to study biological tissue. Some characteristics of cancerous tissue are revealed at the molecular level. This new spectral technique has some unique advantages in addition to its own unique advantages. Compared with the traditional pathological diagnosis, the development of THz-TDS technology in medical field may provide rapid and nondestructive diagnostic results. Moreover, it is more sensitive to the early diagnosis of cancerous tissue. In this paper, the principle and application potential of terahertz time-domain spectroscopy are briefly described. This paper emphatically introduces the research work of this technology in the field of medical diagnosis. The THz-TDS system in the laboratory is improved: the original manual scanning imaging system is changed into an automatic motor control scanning system. The mechanical structure of the two-dimensional translation platform was redesigned. The THz time-domain spectra of normal skin and cancerous tissues were obtained by using the transmission terahertz time-domain spectroscopy (THz). The THz spectral lines are analyzed. Firstly, the contour of the sample and the region of the diseased tissue are described by the data imaging of the THz time-domain signal through the sample, and then the frequency-domain signal is obtained by Fourier transform. The absorption curves of THz at several measuring points of samples were further calculated. By observing these curves, the absorption peaks of the samples at 1.35 THZ 1.65 THz and 2.2 THz were obtained. The data of the three sensitive absorption peaks were used to image the samples respectively. The results showed that the canceration components in skin tissues at 1.35 THz and 1.65 THz absorbed THz obviously, and the areas with strong absorption in imaging results were close to those diagnosed by pathology. The results show that the frequency band of THz in skin tissue diagnosis should be controlled in the low frequency range below 2.2 THz. A comparative study of the terahertz spectra of normal skin and cancerous tissues shows that the THz spectra of normal skin and cancerous tissues show a great difference, and some scholars have analyzed that the absorption of THz by water is relatively strong. The cancerous tissue is more abundant in nutrition and higher in water content than healthy tissue. In this paper, the difference should also come from the comprehensive influence of the change of components in cancerous tissue. The study shows that THz-TDS technique is feasible in biomedical diagnosis.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R739.5;R319

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 煙鳳蕓;皮膚組織癌變特性的太赫茲光譜研究[D];天津大學(xué);2012年

，

本文編號：1569072