本文關(guān)鍵詞： 尖銳濕疣 人乳頭瘤病毒亞型 細(xì)胞免疫功能　出處：《中國艾滋病性病》2017年12期 　論文類型：期刊論文

【摘要】：目的分析不同病程尖銳濕疣(CA)患者感染人乳頭瘤病毒(HPV)亞型情況和細(xì)胞免疫功能。方法收集CA患者468例,設(shè)立病程3個月的258例患者為A組,3個月的210例患者為B組,同時設(shè)立對照組30例。CA患者取疣體細(xì)胞進(jìn)行HPV-脫氧核糖核酸(DNA)分型檢測,抽取靜脈血檢測淋巴細(xì)胞亞群和艾滋病病毒抗體。對照組取泌尿生殖系統(tǒng)脫落細(xì)胞,并抽取靜脈血,檢測同CA患者。結(jié)果 468例CA患者中,HPV亞型檢出率由高到低依次HPV6(34.2%),HPV11(26.5%),HPV52(12.0%)、HPV16(10.3%)。A、B兩組患者共檢出HPV亞型陽性結(jié)果為754個,低危型321個,占42.6%,高危型433個,占57.4%。A組364個,其中低危型180個(49.5%),高危型184個(50.5%);B組390個,其中低危型141個(36.2%),高危型249個(63.8%)。B組患者多重感染比例為43.8%(92/210),A組為27.1%(70/258),差異有統(tǒng)計學(xué)意義(χ2=14.23,P0.01)。CA患者CD4+、CD4+/CD8+低于對照組,CD8+高于對照組,其中B組顯示的差異更為顯著。結(jié)論 HPV高危亞型感染以及與高危亞型合并的多重感染,同時機(jī)體細(xì)胞免疫功能低下是CA復(fù)發(fā)的重要因素。
[Abstract]:Objective to analyze the subtypes and cellular immune function of human papillomavirus (HPV) infection in patients with CAA with different course of disease. Methods A group of 258 patients with 3 months course of disease and 210 patients with 3 months course of disease were selected as group B and 468 patients with CA. At the same time, 30 patients with CA in the control group were selected to take out warts cells for HPV-DNA DNA typing, and venous blood was extracted to detect lymphocyte subsets and HIV antibodies, while the control group took exfoliated cells from the genitourinary system and extracted venous blood. Results in 468 patients with CA, the positive rate of HPV subtype was 754, 321 low, 42.6, 433 high-risk type, 57.44.A, 57.40.The positive rate of HPV subtype was 754, 321 low risk type, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, 42.6%, respectively, and the positive results of HPV subtype were 754, 42.6, 57.44.A, 57.44.The positive results were 754, 321 low risk type, 42.6%, 42.6%, 42.6%, 42.6%, 42.6% and 42.6%, respectively, in 468 patients with CA. Among them, 180 cases of low risk type were 49.55%, 184 cases of high risk type (184 cases) were divided into group B (390 cases), there were 141 cases with low risk type (36.2%) and 249 cases with high risk type (group B with 63.8%). The rate of multiple infection in group B was 43.82%. The ratio of multiple infection in group A was 27.1% 70% 258U, the difference was statistically significant (蠂 2, 14.23%, P 0.01A, CA, P 0.01M, CA), and the ratio of CD4 / CD8 in patients with CD4 / CD8 was lower than that in control group (P < 0.05), but the ratio of CD 4 / CD 8 in group B was significantly lower than that in group B (P < 0.05). Conclusion HPV high risk subtype infection and multiple infection combined with high risk subtype, and low cellular immune function are important factors for CA recurrence.
【作者單位】： 廣州市皮膚病防治所;
【分類號】：R752.53

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