本文關(guān)鍵詞： LPP 白癜風(fēng) 單核苷酸多態(tài)性 相關(guān)性 中國蒙古族　出處：《中國皮膚性病學(xué)雜志》2016年09期 　論文類型：期刊論文

【摘要】：目的探討LPP(Lim domain containing preferred translocation partner in lipoma)基因多態(tài)性與中國蒙古族人群白癜風(fēng)患者的遺傳相關(guān)性。方法收集425例蒙古族白癜風(fēng)及503例蒙古族健康對照外周血,選擇位于LPP基因區(qū)域的4個單核苷酸多態(tài)性(SNP)位點(diǎn)(rs13076312,rs13091753,rs1464510和rs1559810),應(yīng)用連接酶檢測反應(yīng)(Ligase detection reaction,LDR)進(jìn)行基因分型。利用PLINK1.07軟件進(jìn)行統(tǒng)計(jì)分析,χ~2檢驗(yàn)比較病例組及對照組等位基因頻率及基因型頻率,并計(jì)算等位基因的相對危險(xiǎn)度估計(jì)值比值比(OR)及其95%可信區(qū)間(95%CI)。結(jié)果 2個SNP(rs13076312_C,rs1464510_G)等位基因頻率在白癜風(fēng)組顯著低于對照組(P0.01)。rs13076312在顯性模式下,基因型頻率在白癜風(fēng)組與對照組間差異有統(tǒng)計(jì)學(xué)意義(P0.01),rs1464510在隱形遺傳模式下,白癜風(fēng)組基因型頻率明顯低于對照組,差異均具統(tǒng)計(jì)學(xué)意義(P0.01)。兩個SNP(rs13091753和rs1559810)等位基因頻率在白癜風(fēng)組和對照組中差異無統(tǒng)計(jì)學(xué)意義(P0.09)。結(jié)論 LPP基因多態(tài)性與蒙古族白癜風(fēng)具有相關(guān)性。
[Abstract]:Objective to investigate the genetic association of LPP(Lim domain containing preferred translocation partner in lipomia with Chinese Mongolian patients with vitiligo. Methods Peripheral blood samples were collected from 425 Mongolian patients with vitiligo and 503 healthy controls. Four single nucleotide polymorphisms (SNPs) loci, rs13076312, rs13091753, rs1464510 and rs1559810, located in the region of LPP gene, were selected for genotyping. PLINK1.07 software was used for statistical analysis and 蠂 2 test for comparison of alleles between case group and control group. Because of frequency and genotype frequency, Results the frequencies of two SNPs 13076312Cnrs1464510G alleles in vitiligo group were significantly lower than those in control group (P0.01n.rs13076312) in dominant mode. There was significant difference in genotype frequency between vitiligo group and control group. The genotype frequency of vitiligo group was significantly lower than that of control group. The allelic frequencies of two SNP(rs13091753 and rs1559810 alleles were not significantly different in vitiligo group and control group. Conclusion there is a correlation between LPP gene polymorphism and Mongolian vitiligo.
【作者單位】： 內(nèi)蒙古醫(yī)科大學(xué)附屬醫(yī)院皮膚科;呼倫貝爾市人民醫(yī)院皮膚科;錫林浩特市蒙醫(yī)院;
【基金】：國家自然科學(xué)基金(81160189)
【分類號】：R758.41
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本文編號：1505823