Lipoxin A4 can alleviate cerebral ischemia/reperfusion injury by reducing the inflammatory reaction,but it is currently unclear whether it has a protective effect on diabetes mellitus complicated by focal cerebral ischemia/reperfusion injury.In this study,we established rat models of diabetes mellitus using an intraperitoneal injection of streptozotocin.We then induced focal cerebral ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 hours.A... 

【文章來源】：Neural Regeneration Research. 2016,11(04)SCICSCD

【文章頁(yè)數(shù)】：5 頁(yè)

【文章目錄】：
Graphical Abstract
Introduction
Materials and Methods
    Ethics statement and experimental animals
    Induction of DM
    Establishment of rat models of focal cerebral I/R injury
    LXA4 administration
    Neurological deficit evaluation
    Infarct volume
    Western blot assay
    Statistical analysis
Results
    LXA4 improved the neurological function of diabetic rats with cerebral I/R injury
    LXA4 reduced the brain infarct volume in diabetic rats with cerebral I/R injury
    LXA4 decreased TNF-αand NF-κB expression in the cerebral cortex of diabetic rats with cerebral I/R injury
Discussion



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