【摘要】：目的:檢測糖尿病腎病患者血清中高遷移率族蛋白B1(HMGB1)及相關(guān)炎癥因子和氧化應(yīng)激指標(biāo),探討HMGB1在糖尿病腎病發(fā)生發(fā)展中的作用。方法:收集120例臨床糖尿病腎病及60例單純糖尿病患者的臨床資料及血液標(biāo)本。臨床糖尿病腎病患者按24 h尿白蛋白定量分為微量白蛋白尿組(n=60)和大量白蛋白尿組(n=60)。檢測血液中糖化血紅蛋白(Hb A1c)、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯(TG)、肌酐等水平,并采用酶聯(lián)免疫吸附(ELISA)法檢測血清中HMGB1、晚期糖基化終末產(chǎn)物受體(RAGE)、丙二醛(MDA)、腫瘤壞死因子α(TNF-α)濃度。變量之間相關(guān)性分析采用Pearson相關(guān)性分析。結(jié)果:1臨床糖尿病腎病組血清中HMGB1、RAGE、TNF-α、MDA水平高于單純糖尿病組,且差異具有統(tǒng)計(jì)學(xué)意義(P0.01);2HMGB1、RAGE、TNF-α、MDA在大量白蛋白尿組中表達(dá)量最高;3HMGB1與RAGE、TNF-α、MDA呈正相關(guān)。結(jié)論 :HMGB1在臨床糖尿病腎病患者血清中水平顯著升高,且隨著蛋白尿加重,其血清中的水平亦升高。HMGB1可能通過促進(jìn)炎癥反應(yīng)及氧化應(yīng)激等機(jī)制參與糖尿病腎病發(fā)生發(fā)展。
[Abstract]:Objective: to detect serum high mobility group protein B1 (HMGB1), related inflammatory factors and oxidative stress in patients with diabetic nephropathy, and to explore the role of HMGB1 in the occurrence and development of diabetic nephropathy. Methods: the clinical data and blood samples of 120 cases of clinical diabetic nephropathy and 60 cases of simple diabetes mellitus were collected. The patients with diabetic nephropathy were divided into microalbuminuria group (n 鈮，

本文編號(hào)：2522021