【摘要】：目的探討飲酒及其他生活方式因子的交互作用對2型糖尿病(type 2diabetes mellitus,T2DM)發(fā)生風(fēng)險(xiǎn)的影響。方法 2015年6月—2016年2月,利用簡單隨機(jī)抽樣方法,在淮南市東方醫(yī)院與淮南市體檢中心分別選取320例T2DM患者和640例同期健康體檢者,比較兩組間一般人口學(xué)信息、飲酒、吸煙、體力活動和飲食行為方面的差異,運(yùn)用非條件Logistic回歸與廣義多因子降維法(GMDR)進(jìn)行統(tǒng)計(jì)分析。結(jié)果 (1)Logistic回歸分析結(jié)果顯示:調(diào)整混雜因素后,各食物條目攝入得分相對于Q1,糧谷類(OR=0.301,95%CI 0.153~0.628)、蔬菜水果類(OR=0.444,95%CI 0.245~0.806)、奶及奶制品(OR=0.510,95%CI 0.329~0.790)、豆類(OR=0.434,95%CI 0.212~0.901)、紅肉類(OR=0.461,95%CI 0.229~0.926)、西方食物類(OR=0.223,95%CI 0.076~0.652)、含糖飲料類(OR=0.150,95%CI0.035~0.643)攝入得分為Q5以及體質(zhì)指數(shù)24.0(OR=0.189,95%CI 0.109~0.329)為罹患T2DM的保護(hù)因素;而經(jīng)常飲酒(OR=3.936,95%CI 1.145~8.734)、中等強(qiáng)度體力活動5次/周(OR=1.558,95%CI 1.013~2.876)為罹患T2DM的危險(xiǎn)因素。(2)相乘交互作用分析顯示:經(jīng)常飲酒分別與攝入糧谷類(Q5)(OR=0.852,95%CI 0.765~0.949)、蔬菜水果類(Q5)(OR=0.862,95%CI 0.757~0.982)及中等體力活動≥5次/周(OR=0.613,95%CI 0.468~0.803)間存在相乘交互作用。(3)相加交互作用分析顯示:經(jīng)常飲酒分別與高攝入紅肉、含糖飲料及中等體力活動≥5次/周間存在相加交互作用。(4)GMDR法分析顯示:含糖飲料、紅肉和經(jīng)常飲酒三因素間存在交互作用共同影響T2DM的發(fā)生(P=0.001)。結(jié)論經(jīng)常飲酒與其他多種可控因素間存在交互作用共同影響T2DM的發(fā)生。
[Abstract]:Objective to investigate the effects of alcohol consumption and other lifestyle factors on the risk of type 2 diabetes mellitus (type 2diabetes mellitus,T2DM). Methods from June 2015 to February 2016, 320 T2DM patients and 640 healthy people were selected from Dongfang Hospital of Huainan City and Huainan City physical examination Center, respectively. The general demographic information and drinking were compared between the two groups. The differences in smoking, physical activity and dietary behavior were analyzed by non-conditional Logistic regression and generalized multi-factor dimensionality reduction method (GMDR). Results (1) the results of Logistic regression analysis showed that after adjusting for confounding factors, the intake scores of food items were relative to Q1, grains (OR=0.301,95%CI 0.153 0. 628), vegetables and fruits (OR=0.444,95%CI 0. 245 0. 806). Milk and dairy products (OR=0.510,95%CI 0.3290.0.790), beans (OR=0.434,95%CI 0.212o0.901), red meat (OR=0.461,95%CI 0.2290.926), western foods (OR=0.223,95%CI 0.0760.0.652), The intake score of sugary drinks (OR=0.150,95%CI0.035~0.643) was Q5 and BMI 24.0 (OR=0.189,95%CI 0.109 0.329) was the protective factor of T2DM. And frequent drinkers (OR=3.936,95%CI 1.145, 8.734), Five moderate intensity physical activities per week (OR=1.558,95%CI 1.013 ~ 2.876) were risk factors for T2DM. (2) multiplicative interaction analysis showed that regular drinking was associated with grain intake (Q5) (OR=0.852,95%CI 0.7650.949). There is a multiplicative interaction between fruits and vegetables (OR=0.862,95%CI 0.7570.9082) and moderate physical activity (OR=0.613,95%CI 0.468 0.803). (3) the additive interaction analysis shows that: frequent Drinking and high intake of red meat, There was additive interaction between sugary beverage and moderate physical activity (鈮，

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