發(fā)布時間：2019-01-05 08:16

【摘要】：目的腦梗死患者中關(guān)于亞臨床甲狀腺功能和內(nèi)脂素、內(nèi)皮素關(guān)系的研究較少。文中旨在探討腦梗死合并亞臨床甲狀腺功能減退(簡稱甲減)患者甲狀腺功能與內(nèi)脂素、內(nèi)皮素的關(guān)系。方法入選2011年1月至2017年7月海南醫(yī)學院第二附屬醫(yī)院內(nèi)分泌科及老年病科腦梗死患者200例。將其分為4組:對照組[腦梗死合并甲狀腺功能正常,促甲狀腺激素(TSH)、游離甲狀腺素(FT4)、游離三碘甲狀腺原氨酸(FT3)均正常,n=40]、輕度亞臨床甲減組(4≤TSH10 m IU/L,FT3、FT4正常,n=60)、重度亞臨床甲減組(TSH≥10 m IU/L,FT3、FT4正常,n=60)、臨床甲減組(TSH≥4 m IU/L,FT3、FT4降低,n=40)。其中輕度亞臨床甲減組隨機分為輕度服藥亞組、輕度未服藥亞組;重度亞臨床甲減組患者隨機分為重度服藥亞組、重度未服藥亞組,每組30例。2個服藥組在常規(guī)治療基礎(chǔ)上加用左甲狀腺素片;2個未服藥組采用常規(guī)治療。記錄所有患者年齡、性別、BMI、血壓、血糖、血脂、甲狀腺功能等,比較患者內(nèi)脂素、內(nèi)皮素的差異。結(jié)果重度亞臨床甲減組、臨床甲減組內(nèi)脂素含量[(46.3±10.1)、(49.5±13.6)ng/m L]較對照組[(40.2±9.7)ng/m L]明顯升高(P0.05)。重度服藥亞組6個月時內(nèi)脂素較重度未服藥亞組升高[(42.9±6.4)ng/m L vs(39.3±5.5)ng/m L,P0.05]。結(jié)論相對于甲狀腺功能正常的腦梗死患者,重度亞臨床甲減合并腦梗死患者與內(nèi)脂素關(guān)系更密切。對腦梗死患者應積極篩查甲狀腺功能,及早發(fā)現(xiàn)和干預重度亞臨床甲減非常必要。
[Abstract]:Objective to study the relationship between subclinical thyroid function and endothelin in patients with cerebral infarction. The purpose of this study was to investigate the relationship between thyroid function and endothelin (et) in patients with subclinical hypothyroidism (hypothyroidism) after cerebral infarction. Methods from January 2011 to July 2017, 200 patients with cerebral infarction in Department of Endocrinology and Department of Geriatrics, second affiliated Hospital of Hainan Medical College were selected. It was divided into four groups: control group [cerebral infarction with normal thyroid function, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3) were normal, nm40]. Mild subclinical hypothyroidism (4 鈮，

本文編號：2401507