【摘要】：目的探究豬油與植物黃油飲食對不同部位脂肪組織單核細(xì)胞趨化蛋白-1(MCP-1)表達(dá)水平的影響。方法 2015年4—6月,選取健康的初斷乳SPF級、Wistar雄性大鼠49只,隨機(jī)分為對照組(CON組,n=7)、豬油組(L組,n=21)、植物黃油組(M組,n=21)。CON組大鼠采用基礎(chǔ)飼料喂養(yǎng),L組大鼠采用含豬油的高脂飼料喂養(yǎng),M組大鼠采用含植物黃油的高脂飼料喂養(yǎng)。3組大鼠均飼養(yǎng)8周,結(jié)束時(shí)將L組和M組大鼠按體質(zhì)量增加量的前1/3和后1/3分別分為豬油-肥胖傾向組(L-OP組,n=7)、植物黃油-肥胖傾向組(M-OP組,n=7)和豬油-肥胖抵抗組(L-OR組,n=7)、植物黃油-肥胖抵抗組(M-OR組,n=7),其余棄去。比較5組大鼠體質(zhì)量增加量、附睪周脂肪系數(shù)、腎周脂肪系數(shù)及皮下、附睪周、腎周脂肪組織MCP-1表達(dá)水平。結(jié)果 L-OP組、MOP組大鼠體質(zhì)量增加量均大于CON組(P0.05);L-OP組、M-OP組、M-OR組大鼠附睪周脂肪系數(shù)均大于CON組(P0.05);L-OP組、L-OR組、M-OP組、M-OR組大鼠腎周脂肪系數(shù)均大于CON組(P0.05)。5組大鼠附睪周脂肪組織MCP-1表達(dá)水平比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05);L-OP組、L-OR組、M-OP、M-OR組大鼠皮下脂肪組織MCP-1表達(dá)水平均高于CON組(P0.05);M-OP組、M-OR組大鼠腎周脂肪組織MCP-1表達(dá)水平均高于CON組(P0.05)。結(jié)論與豬油相比,植物黃油更能引起皮下、腎周脂肪組織MCP-1表達(dá)水平升高。
[Abstract]:Objective to investigate the effect of lard and vegetable butter diet on the expression of monocyte chemoattractant protein-1 (MCP-1) in adipose tissues. Methods from April to June 2015, 49 male Wistar rats were randomly divided into three groups: control group (CON group, n = 7), lard group (L group, n = 21), vegetable butter group (M group, n = 21). CON group). Rats in group L were fed with high fat diet containing lard, and rats in group M were fed with high fat diet containing vegetable butter. At the end of the study, rats in group L and group M were divided into lard obesity prone group (L-OP group, n = 7) and butter-obesity prone group (M-OP group), respectively. The rest were abandoned in the lard obesity resistance group (L-OR group, nong7 group), butter-obesity resistance group (M-OR group, nong7 group) and lard fat resistance group (L-OR group, nong7 group). The body weight increase, peri-epididymal fat coefficient, perirenal fat coefficient and MCP-1 expression levels in subcutaneous, peri-epididymal and perirenal adipose tissues were compared among the five groups. Results the increase of body mass in L-OP group and MOP group was higher than that in CON group (P0.05), the periepididymal fat coefficient in L-OP group, M-OP group and M-OR group was higher than that in CON group (P0.05). The perirenal fat coefficients of L-OP group, L-OR group, M-OP group and M-OR group were higher than that of CON group (P0.05). There was no significant difference in the expression of MCP-1 in peri-epididymal adipose tissue in 5 groups (P0.05). The expression of MCP-1 in subcutaneous adipose tissue of L-OP group, L-OR group and M-OPN M-OR group was higher than that of CON group (P0.05). The expression of MCP-1 in perirenal adipose tissue in M-OP group and M-OR group was higher than that in CON group (P0.05). Conclusion compared with lard, vegetable butter can induce more subcutaneous and elevated MCP-1 expression in perirenal adipose tissue.
【作者單位】： 中國醫(yī)科大學(xué)公共衛(wèi)生學(xué)院兒少衛(wèi)生與婦幼保健學(xué)教研室;鄂東醫(yī)療集團(tuán)黃石市中心醫(yī)院質(zhì)量管理部;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81373018)
【分類號】：R589.2

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