【摘要】：目的探討中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)及紅細(xì)胞分布寬度(RDW)對亞甲炎的診斷價(jià)值。方法回顧性分析2014年4月-2016年10月河南中醫(yī)藥大學(xué)第二附屬醫(yī)院收治的89例亞甲炎患者作為研究組,另選取78例其他甲狀腺疾病患者和80例健康體檢者,比較各組中的紅細(xì)胞分布寬度(RDW)、中性粒細(xì)胞與淋巴細(xì)胞比值(NLR)、甲狀腺球蛋白(Tg)、甲狀腺結(jié)合球蛋白抗體(TG-Ab)、甲狀腺過氧化物酶抗體(TPOAb)、促甲狀腺激素受體抗體(TRAb)、甲狀腺微粒體抗體(TMAb)以及FT3、FT4、TSH之間的差異關(guān)系,采用Pearson相關(guān)分析及多元逐步線性回歸分析RDW、NLR與其他指標(biāo)的關(guān)系,采用ROC曲線來比較各指標(biāo)的診斷價(jià)值。結(jié)果亞甲炎組和其他組的RDW值均高于正常對照組,而NLR值則低于正常對照組;RDW與TSH、TPOAb分別具有相關(guān)性,相關(guān)系數(shù)分別為-0.43和0.33(P0.05);NLR與FT3則呈現(xiàn)正相關(guān),相關(guān)系數(shù)為0.47(P0.05);ROC分析曲線表明,Tg是亞甲炎的最佳診斷指標(biāo),RDW,NLR也可作為較佳診斷指標(biāo)。結(jié)論 NLR、RDW聯(lián)合Tg,更能對亞甲炎做出有效診斷,對于聯(lián)合性分析具有一定的價(jià)值。
[Abstract]:Objective to investigate the diagnostic value of neutrophil / lymphocyte ratio (NLR) and erythrocyte distribution width (RDW) in subthyroiditis. Methods from April 2014 to October 2016, 89 patients with subthyroiditis admitted in the second affiliated Hospital of Henan University of traditional Chinese Medicine were selected as the study group, 78 patients with other thyroid diseases and 80 healthy controls were selected. (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), were compared in each group by comparing the red blood cell distribution width (RDW), neutrophil / lymphocyte ratio (NLR), thyroglobulin (Tg), thyroid binding globulin antibody (TG-Ab) and thyroid peroxidase antibody (TPOAb), The difference of (TMAb) and FT3,FT4,TSH between (TRAb), thyroid microsomal antibody and FT3,FT4,TSH was studied. The relationship between RDW,NLR and other indexes was analyzed by Pearson correlation analysis and multiple stepwise linear regression analysis. ROC curve was used to compare the diagnostic value of each index. Results the RDW value of subthyroitis group and other groups were higher than that of normal control group, but the NLR value was lower than that of normal control group, RDW and TSH,TPOAb had correlation coefficient of -0.43 and 0.33 (P0.05). There was a positive correlation between NLR and FT3, the correlation coefficient was 0.47 (P0.05); ROC analysis curve showed that Tg is the best diagnostic index of subthyroiditis, RDW,NLR can also be used as a better diagnostic index. Conclusion NLR,RDW combined with Tg, is more effective in the diagnosis of thyroiditis.
【作者單位】： 河南中醫(yī)藥大學(xué)第二附屬醫(yī)院檢驗(yàn)科;
【基金】：河南省科技攻關(guān)項(xiàng)目(132102310244)
【分類號】：R446.1;R581.4

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