中年人群體育鍛煉與血脂血糖水平的橫斷面研究
發(fā)布時(shí)間：2018-11-18 18:35
【摘要】：背景隨著生活水平的提高及生活方式的改變,我國(guó)人群高血脂、糖尿病的患病率也持續(xù)升高。血脂異常、糖尿病是心血管疾病的獨(dú)立危險(xiǎn)因素。加強(qiáng)生活方式干預(yù)可改善機(jī)體的血脂水平,降低或推遲糖尿病的發(fā)生。大量隨機(jī)對(duì)照試驗(yàn)證據(jù)顯示,體力活動(dòng)對(duì)血脂異常等具有良好的保護(hù)作用,增加體力活動(dòng)可降低糖尿病人糖化血紅蛋白(HbAlc)水平,有利于糖尿病病人的血糖控制。另外,國(guó)外也有人群研究報(bào)道增加體力活動(dòng)可以改善血脂水平,降低糖尿病的發(fā)生風(fēng)險(xiǎn)。但是關(guān)于社區(qū)人群多樣性體育鍛煉與血脂、血糖水平之間的關(guān)聯(lián)的研究還較少。此外,國(guó)內(nèi)相關(guān)的人群研究也較為缺乏。本研究在我國(guó)南北方城鄉(xiāng)中年人群中探討體育鍛煉能耗與血脂、血糖水平之間的關(guān)聯(lián)。目的探討體育鍛煉與血脂水平的關(guān)聯(lián)；探討體育鍛煉與血糖水平之間的關(guān)系。方法研究人群來(lái)自于中國(guó)心血管流行病學(xué)多中心協(xié)作研究對(duì)象中北京、廣州城鄉(xiāng)四組人群,共計(jì)3644名,年齡35-59歲,剔除了資料不完整或缺失的研究對(duì)象58名,排除調(diào)查時(shí)有腦卒中、冠心病及惡性腫瘤病史等的194人,共有3392名作為本次分析對(duì)象。采用調(diào)查問(wèn)卷法收集一般人口統(tǒng)計(jì)學(xué)資料、疾病史、行為生活習(xí)慣及平時(shí)體育鍛煉情況等數(shù)據(jù),并進(jìn)行體格檢查及生化指標(biāo)的檢測(cè)。采用代謝當(dāng)量值(MET)估計(jì)體育鍛煉強(qiáng)度,并根據(jù)其鍛煉時(shí)間計(jì)算平時(shí)每日體育鍛煉能量能耗(Energy Expenditure of Exercise, EEexer)。采集空腹靜脈血,采用統(tǒng)一的標(biāo)準(zhǔn)化方法測(cè)定總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯(TG)及血糖(Glu)水平,并利用所測(cè)血脂指標(biāo)計(jì)算非高密度脂蛋白膽固醇(non HDL-C)及低密度脂蛋白膽固醇(LDL-C)水平(Friedewald公式)。使用SAS 9.3進(jìn)行統(tǒng)計(jì)分析,計(jì)量資料用均數(shù)±標(biāo)準(zhǔn)差表示,利用方差分析進(jìn)行組間差異比較,計(jì)數(shù)資料用百分位數(shù)表示,采用卡方檢驗(yàn)進(jìn)行比較；利用協(xié)方差分析,采用三種模型評(píng)估體育鍛煉能耗與TC、LDL-C、non HDL-C、HDL-C、TG及血糖水平之間的關(guān)聯(lián),模型1：控制年齡、城鄉(xiāng)、文化程度；模型2：在模型1基礎(chǔ)上控制吸煙、飲酒、BMI；模型3：在模型2基礎(chǔ)上進(jìn)一步控制體育鍛煉以外的體力活動(dòng)能耗(Energy Expenditure ofPhysical Activity outside of Exercise,EEPA);以P小于0.05為組間差異具有顯著性。結(jié)果1. 研究人群的體育鍛煉情況在總?cè)巳褐?有體育鍛煉的有1487人,占總?cè)巳旱?3.84%(1487/3392)；男性中有體育鍛煉的有773人,占男性的46.74%(773/1654)；女性中有714人,占的41.08%(714/1738)�？�?cè)巳�、男、女性體育鍛煉人群中,鍛煉能耗中位數(shù)分別為2.56 MET·h·d1、2.52 MET·h·d-1、2.63 MET·h·d-1。2. 體育鍛煉能耗與血脂水平之間的關(guān)聯(lián)根據(jù)研究人群體育鍛煉情況為三組,即無(wú)體育鍛煉組、體育鍛煉日均耗能(EEexer)中位數(shù)以下組(體育鍛煉較少組)和中位數(shù)以上組(體育鍛煉較多組)。利用協(xié)方差分析,評(píng)估體育鍛煉能耗與血脂水平之間的關(guān)聯(lián)。單因素分析：男性中,與無(wú)鍛煉組相比,兩個(gè)體育鍛煉組血清non HDL-C水平較高(P0.05), HDL-C水平較低(P0.05)。血清TC、LogTG、LDL-C三組間均無(wú)顯著差異(P0.05)。女性中,兩鍛煉組TC、LogTG、non HDL-C水平高于無(wú)鍛煉組(P0.05), HDL-C、LDL-C三組間無(wú)顯著差異(P0.05)多因素分析：女性總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、非高密度脂蛋白膽固醇(non HDL-C)、甘油三酯(LogTG)兩鍛煉組要低于無(wú)鍛煉組,其中LDL-C及non HDL-C水平組間差異有統(tǒng)計(jì)學(xué)意義(P0.05)；與無(wú)鍛煉組比,女性體育鍛煉較多組LDL-C及non HDL-C水平降低約0.14mmol/L (P=0.0075)、 0.14mmol/L (P=0.0145);男性TC、LDL-C、non HDL-C、TG水平兩鍛煉組要低于無(wú)鍛煉組,但差異無(wú)統(tǒng)計(jì)學(xué)意義。高密度脂蛋白膽固醇(HDL-C)在男/女性中,三組間差別均無(wú)統(tǒng)計(jì)學(xué)意義。3. 體育鍛煉能耗與血糖水平之間的關(guān)聯(lián)單因素分析顯示,男、女性中兩鍛煉組血糖水平要低于無(wú)鍛煉組,組間差異均有統(tǒng)計(jì)學(xué)意義(P0.05)多因素分析顯示,男、女性中,與無(wú)鍛煉組比,兩鍛煉組血糖水平顯著較低,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。兩兩比較顯示,體育鍛煉較高組(EEexer2.63 MET·h·d-1)與無(wú)鍛煉人群相比,男性血糖水平降低0.17mmol/L (P0.05),女性降低0.14mmol/L (P0.05)。結(jié)論一定量的業(yè)余時(shí)間體育鍛煉有利于改善女性L(fǎng)DL-C、non HDL-C水平。體育鍛煉可改善男、女性血糖水平,二者中血糖水平均隨著鍛煉能耗的升高而降低。
[Abstract]:With the improvement of living standard and the change of life style, the prevalence of hyperlipemia and diabetes in our population is also rising. Dyslipidemia, diabetes is an independent risk factor for cardiovascular disease. Strengthening lifestyle intervention can improve the blood lipid level of the body, reduce or delay the occurrence of diabetes. A large number of randomized controlled trials have shown that physical activity has a good protective effect on dyslipidemia and the like, and the increase of physical activity can reduce the level of glycosylated hemoglobin (HbAlc) in patients with diabetes, and is beneficial to the control of blood sugar in patients with diabetes. In addition, there are also a group of studies abroad to report that the increase of physical activity can improve the level of blood fat and reduce the risk of diabetes. However, the study of the association between the physical exercise of the community and the level of blood fat and blood sugar is less. In addition, there is a lack of research on the population in the country. The relationship between the energy consumption of physical exercise and the level of blood fat and blood sugar was discussed in the middle-aged and rural middle-aged people in the south of China. Objective To study the relationship between physical exercise and blood lipid level, and to explore the relationship between physical exercise and blood sugar level. Methods A total of 3,44 study subjects from Beijing and Guangzhou, aged 35 to 59, were selected from China's cardiovascular and epidemiological multi-center cooperation study, and 58 of the subjects were excluded from incomplete or missing data. There were 194 cases of coronary heart disease and the history of malignant tumor, with a total of 3392 as the subject of this analysis. The data of general population statistics, the history of the disease, the behavior of behavior and the physical exercise of the general population were collected by the questionnaire method, and the physical examination and the biochemical indexes were tested. The exercise intensity is estimated by the amount of metabolism (MET) and the energy energy of exercise of exercise is calculated on the basis of the exercise time. fasting venous blood was collected and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and blood glucose (Glu) levels were determined by a unified standardized method, and the non-high-density lipoprotein cholesterol (non-HDL-C) and the low-density lipoprotein cholesterol (LDL-C) level (Friedewald formula) were calculated using the measured blood lipid index. The statistical analysis was carried out using SAS 9.3. The mean square standard deviation of the data used for the measurement was expressed by means of variance analysis. The percentile expression of the count data was compared with the test of the card. Using the analysis of the covariance, three models were used to evaluate the energy consumption of physical exercise and TC, LDL-C, Association between non-HDL-C, HDL-C, TG and blood glucose levels, model 1: control age, urban and rural, cultural level; model 2: control smoking, drinking, BMI on the basis of model 1; model 3: The energy consumption of physical activity (EEPA) other than physical exercise was further controlled on the basis of model 2. Results 1. The physical exercise of the study population in the general population, there were 1487 people with physical exercise, 43. 84% of the total population (1487/ 3392), 773 of the male with physical exercise, 46. 74% of the male (773/ 1654), and 714 in the female, accounting for 41.08% (714/ 1738). The median energy consumption was 2.56 MET 路 h 路 d1, 2.52 MET 路 h 路 d-1, 2.63 MET 路 h 路 d-1. The association between the energy consumption of physical exercise and the level of blood fat was divided into three groups according to the study population, that is, there was no physical exercise group, and the average daily energy consumption of physical exercise (EEx) was the following group (lower group of physical exercise) and the above group (group of physical exercises). The correlation between the energy consumption of physical exercise and the level of blood fat was assessed by the analysis of covariance. Single factor analysis: Compared with the non-exercise group, the serum non-HDL-C level in the two exercise groups was higher (P0.05), and the level of HDL-C was lower (P0.05). There was no significant difference between the three groups of serum TC, LogTG and LDL-C (P0.05). In women, the levels of TC, LogTG and non-HDL-C in both exercise groups were higher than that in the non-exercise group (P0.05), and there was no significant difference between the three groups of HDL-C and LDL-C (P0.05): total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C). The levels of LDL-C and non-HDL-C decreased by about 0.14mmol/ L (P = 0. 0075), 0.14mmol/ L (P = 0.0145), male TC, LDL-C, non-HDL-C. The level of TG was lower than that of the non-exercise group, but the difference was not significant. The difference of high-density lipoprotein cholesterol (HDL-C) in male/ female was not statistically significant. The analysis of the correlation between the energy consumption and the blood sugar level showed that the blood sugar level of the two exercise groups in the male and female group was lower than that of the non-exercise group, and the difference between the group and the group was statistically significant (P0.05). The blood glucose level of the two exercise groups was significantly lower, and the difference was statistically significant (P0.05). Compared with the non-exercise group, the level of blood glucose decreased by 0.17mmol/ L (P0.05), and that of female was 0.14mmol/ L (P0.05). Conclusion Exercise can improve the level of LDL-C and non-HDL-C in female. Physical exercise can improve the blood sugar level of male and female, and the blood sugar level in both of them decrease with the increase of the energy consumption of exercise.
【學(xué)位授予單位】：北京協(xié)和醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R587.1
本文編號(hào)：2340816
[Abstract]:With the improvement of living standard and the change of life style, the prevalence of hyperlipemia and diabetes in our population is also rising. Dyslipidemia, diabetes is an independent risk factor for cardiovascular disease. Strengthening lifestyle intervention can improve the blood lipid level of the body, reduce or delay the occurrence of diabetes. A large number of randomized controlled trials have shown that physical activity has a good protective effect on dyslipidemia and the like, and the increase of physical activity can reduce the level of glycosylated hemoglobin (HbAlc) in patients with diabetes, and is beneficial to the control of blood sugar in patients with diabetes. In addition, there are also a group of studies abroad to report that the increase of physical activity can improve the level of blood fat and reduce the risk of diabetes. However, the study of the association between the physical exercise of the community and the level of blood fat and blood sugar is less. In addition, there is a lack of research on the population in the country. The relationship between the energy consumption of physical exercise and the level of blood fat and blood sugar was discussed in the middle-aged and rural middle-aged people in the south of China. Objective To study the relationship between physical exercise and blood lipid level, and to explore the relationship between physical exercise and blood sugar level. Methods A total of 3,44 study subjects from Beijing and Guangzhou, aged 35 to 59, were selected from China's cardiovascular and epidemiological multi-center cooperation study, and 58 of the subjects were excluded from incomplete or missing data. There were 194 cases of coronary heart disease and the history of malignant tumor, with a total of 3392 as the subject of this analysis. The data of general population statistics, the history of the disease, the behavior of behavior and the physical exercise of the general population were collected by the questionnaire method, and the physical examination and the biochemical indexes were tested. The exercise intensity is estimated by the amount of metabolism (MET) and the energy energy of exercise of exercise is calculated on the basis of the exercise time. fasting venous blood was collected and total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and blood glucose (Glu) levels were determined by a unified standardized method, and the non-high-density lipoprotein cholesterol (non-HDL-C) and the low-density lipoprotein cholesterol (LDL-C) level (Friedewald formula) were calculated using the measured blood lipid index. The statistical analysis was carried out using SAS 9.3. The mean square standard deviation of the data used for the measurement was expressed by means of variance analysis. The percentile expression of the count data was compared with the test of the card. Using the analysis of the covariance, three models were used to evaluate the energy consumption of physical exercise and TC, LDL-C, Association between non-HDL-C, HDL-C, TG and blood glucose levels, model 1: control age, urban and rural, cultural level; model 2: control smoking, drinking, BMI on the basis of model 1; model 3: The energy consumption of physical activity (EEPA) other than physical exercise was further controlled on the basis of model 2. Results 1. The physical exercise of the study population in the general population, there were 1487 people with physical exercise, 43. 84% of the total population (1487/ 3392), 773 of the male with physical exercise, 46. 74% of the male (773/ 1654), and 714 in the female, accounting for 41.08% (714/ 1738). The median energy consumption was 2.56 MET 路 h 路 d1, 2.52 MET 路 h 路 d-1, 2.63 MET 路 h 路 d-1. The association between the energy consumption of physical exercise and the level of blood fat was divided into three groups according to the study population, that is, there was no physical exercise group, and the average daily energy consumption of physical exercise (EEx) was the following group (lower group of physical exercise) and the above group (group of physical exercises). The correlation between the energy consumption of physical exercise and the level of blood fat was assessed by the analysis of covariance. Single factor analysis: Compared with the non-exercise group, the serum non-HDL-C level in the two exercise groups was higher (P0.05), and the level of HDL-C was lower (P0.05). There was no significant difference between the three groups of serum TC, LogTG and LDL-C (P0.05). In women, the levels of TC, LogTG and non-HDL-C in both exercise groups were higher than that in the non-exercise group (P0.05), and there was no significant difference between the three groups of HDL-C and LDL-C (P0.05): total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C). The levels of LDL-C and non-HDL-C decreased by about 0.14mmol/ L (P = 0. 0075), 0.14mmol/ L (P = 0.0145), male TC, LDL-C, non-HDL-C. The level of TG was lower than that of the non-exercise group, but the difference was not significant. The difference of high-density lipoprotein cholesterol (HDL-C) in male/ female was not statistically significant. The analysis of the correlation between the energy consumption and the blood sugar level showed that the blood sugar level of the two exercise groups in the male and female group was lower than that of the non-exercise group, and the difference between the group and the group was statistically significant (P0.05). The blood glucose level of the two exercise groups was significantly lower, and the difference was statistically significant (P0.05). Compared with the non-exercise group, the level of blood glucose decreased by 0.17mmol/ L (P0.05), and that of female was 0.14mmol/ L (P0.05). Conclusion Exercise can improve the level of LDL-C and non-HDL-C in female. Physical exercise can improve the blood sugar level of male and female, and the blood sugar level in both of them decrease with the increase of the energy consumption of exercise.
【學(xué)位授予單位】：北京協(xié)和醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R587.1
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 吳紅波;陶太珍;顧偉良;陶恭亮;;城市社區(qū)中年人群超重/肥胖現(xiàn)況調(diào)查及影響因素分析[J];九江醫(yī)學(xué);2008年04期
2 周勇;;社區(qū)中年人群超重/肥胖現(xiàn)狀調(diào)查及影響因素分析[J];首都醫(yī)藥;2010年12期
3 謝明仁;連秀珍;俞發(fā)榮;張紅梅;俞貴玲;;中年人群身心健康調(diào)查[J];甘肅科學(xué)學(xué)報(bào);2013年03期
4 沈杰;王冬;解軍;李曉華;;中年人群的自我保健現(xiàn)況及相關(guān)因素分析[J];中國(guó)社會(huì)醫(yī)學(xué);1994年05期
5 俞捷,俞幼娟,顧群,徐潔;干預(yù)措施對(duì)提高社區(qū)中年人群合理營(yíng)養(yǎng)認(rèn)知率的作用[J];上海預(yù)防醫(yī)學(xué)雜志;2005年01期
6 鄧冰;王鳳;庹安軍;歐愛(ài)華;;西部?jī)?nèi)陸與沿海地區(qū)中年人群生存質(zhì)量及影響因素的比較分析[J];貴州醫(yī)藥;2006年03期
7 劉莉莉;李曉玲;Janet sit;;成都市武侯區(qū)中年人群心血管疾病危險(xiǎn)因素的評(píng)估[J];華西醫(yī)學(xué);2007年03期
8 萬(wàn)紅宇;劉建生;田怡;張文燕;;上海市閔行區(qū)體檢中年人群幽門(mén)螺旋桿菌感染狀況調(diào)查[J];實(shí)用醫(yī)學(xué)雜志;2012年10期
9 歐愛(ài)華;梁兆暉;周羅晶;溫麗群;周赫;老膺榮;譚俊軍;鄧冰;王風(fēng);;廣州市與貴陽(yáng)市中年人群生存質(zhì)量及影響因素初探[J];中國(guó)初級(jí)衛(wèi)生保健;2005年10期
10 武陽(yáng)豐,周北凡,李瑩,趙連成,楊軍,匡山,李賢,謝高強(qiáng),張紅葉,吳錫桂,陶壽淇,李義和,劉小清,于學(xué)海,田秀珍,劉利民,夏舜英,王海燕,錢(qián)衛(wèi)沖,朱立光,楊瑞祥,郭東雙,付西漢,阮連生,張文生,郭劍濤,吳兆蘇,吳桂賢,洪震,黃茂盛,袁光固,尹紅,王安兵,褚長(zhǎng)軍,顧吉達(dá),張玉琢,尹其云,張鴻修,?;我國(guó)中年人群心血管病主要危險(xiǎn)因素流行現(xiàn)狀及從80年代初至90年代末的變化趨勢(shì)[J];中華心血管病雜志;2001年02期
相關(guān)會(huì)議論文 前2條
1 張永軍;宋光春;;行為轉(zhuǎn)變理論對(duì)山東中年人體育健身行為干預(yù)實(shí)驗(yàn)[A];中國(guó)科協(xié)2005年學(xué)術(shù)年會(huì)體育科學(xué)分會(huì)場(chǎng)論文摘要匯編[C];2005年
2 李東野;于浩;夏勇;錢(qián)文浩;張超群;李英;葉德壽;;徐州大屯社區(qū)中年人群高血壓病危險(xiǎn)因素的流行病學(xué)調(diào)查研究[A];2005年中國(guó)高血壓年會(huì)論文匯編[C];2005年
相關(guān)重要報(bào)紙文章 前2條
1 范又 李汝正;我國(guó)超重和肥胖者不斷增多[N];光明日?qǐng)?bào);2000年
2 秀秀;在大雅大俗之間跳躍[N];中國(guó)郵政報(bào);2004年
相關(guān)博士學(xué)位論文 前1條
1 武陽(yáng)豐;超重在我國(guó)中年人群的流行趨勢(shì)及與其它心血管病危險(xiǎn)因素的關(guān)系[D];中國(guó)協(xié)和醫(yī)科大學(xué);1996年
相關(guān)碩士學(xué)位論文 前5條
1 秦文;兩種有氧運(yùn)動(dòng)干預(yù)對(duì)中年人群心率變異性的影響[D];西安體育學(xué)院;2015年
2 陳海燕;中年人群體育鍛煉與血脂血糖水平的橫斷面研究[D];北京協(xié)和醫(yī)學(xué)院;2016年
3 劉莉莉;成都市武侯區(qū)中年人群心血管疾病危險(xiǎn)因素的評(píng)估[D];四川大學(xué);2006年
4 郭笑微;水療法方案對(duì)中年人群�；技膊〉木徑夥治鯷D];武漢體育學(xué)院;2015年
5 趙青;成都市區(qū)中年人群休閑體育現(xiàn)狀分析[D];成都體育學(xué)院;2013年
，本文編號(hào)：2340816
本文鏈接：http://sikaile.net/yixuelunwen/nfm/2340816.html
最近更新
教材專(zhuān)著
