甲狀腺功能異;颊哐⒐谴x及骨密度特點的臨床研究
發(fā)布時間:2018-08-25 20:22
【摘要】:目的觀察甲狀腺功能減退癥及甲狀腺功能亢進癥對骨密度以及骨代謝相關指標的影響。方法納入甲狀腺功能減退癥女性37例為甲減組,甲狀腺功能亢進癥女性41例為甲亢組,健康體檢女性人員40例為對照組。觀察3組甲狀腺功能指標血游離三碘甲狀腺原氨酸(FT_3)、游離甲狀腺激素(FT_4)和高敏感促甲狀腺激素(TSH);骨代謝指標血Ca~(2+)、血P~(3+)、1,25-(OH)_2D_3、甲狀旁腺激素(PTH)、堿性磷酸酶(ALP)、血清Ⅰ型膠原羧基端吡啶并啉交聯(lián)肽(ICTP)以及血清骨鈣蛋白(BGP)以及左側股骨頸、正位腰椎1-4(L_(1-4))的骨密度情況。結果甲亢組血清FT_3、FT_4、ALP、BGP、ICTP水平高于對照組(P0.05),甲亢組血清TSH水平低于對照組(P0.05)。甲減組血清TSH水平高于對照組(P0.05),而血清FT_3、FT_4、ALP、BGP、ICTP水平顯著低于對照組(P0.05)。甲亢及甲減組L1-4及左股骨頸骨密度顯著低于對照組(P0.05)。3組受試者PTH、CT、Ca~(2+)、P~(3+)、1,25-(OH)_2D_3比較無統(tǒng)計學意義(P0.05)。結論甲亢及甲減都可以引起骨量丟失,骨密度降低;主要通過影響骨轉化來實現(xiàn)的;應該重視甲狀腺功能異常引起的骨密度及骨代謝異常。
[Abstract]:Objective to investigate the effects of hypothyroidism and hyperthyroidism on bone mineral density and bone metabolism. Methods 37 women with hypothyroidism, 41 women with hyperthyroidism and 40 healthy women as control group were included. Serum free triiodothyronine (FT_3), free thyroid hormone (FT_4) and hypersensitive thyrotropin (TSH);) were measured in the three groups. Serum Ca~ (2), serum P3 ~ (3), 25 (OH) 2D3, parathyroid hormone (PTH), alkaline phosphatase (ALP), serum type 鈪,
本文編號:2203997
[Abstract]:Objective to investigate the effects of hypothyroidism and hyperthyroidism on bone mineral density and bone metabolism. Methods 37 women with hypothyroidism, 41 women with hyperthyroidism and 40 healthy women as control group were included. Serum free triiodothyronine (FT_3), free thyroid hormone (FT_4) and hypersensitive thyrotropin (TSH);) were measured in the three groups. Serum Ca~ (2), serum P3 ~ (3), 25 (OH) 2D3, parathyroid hormone (PTH), alkaline phosphatase (ALP), serum type 鈪,
本文編號:2203997
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