【摘要】：目的探討糖尿病患者黃斑區(qū)視網(wǎng)膜結(jié)構(gòu)變化的頻域OCT(Cirrus HD-OCT)特征,將其測量參數(shù)與正常人群的測量結(jié)果進行比較。方法回顧性分析了由Cirrus HDOCT測量的糖尿病患者黃斑區(qū)視網(wǎng)膜的結(jié)構(gòu)參數(shù)。將糖尿病患眼分為了存在糖尿病視網(wǎng)膜病變(diabetic retinopathy,DR)組和不存在DR組(NDR組),納入與糖尿病患者年齡和性別分布相匹配的健康對照者(對照組),并對三組的黃斑區(qū)神經(jīng)纖維層和神經(jīng)節(jié)細胞-內(nèi)叢狀層(ganglion cell-inner plexiform layer,GCIPL)厚度等參數(shù)進行比較。結(jié)果本研究納入了42例(42眼)2型糖尿病患者(DR組26眼,NDR組16眼),以及30例健康對照者(30眼;對照組)。DR組的GCIPL為(77.2±8.7)μm,NDR組為(79.4±11.3)μm,均小于對照組的(83.2±7.6)μm(均為P0.05)。DR組的最小GCIPL為(65.4±9.3)μm,NDR組為(69.7±7.6)μm,均小于對照組的(76.2±9.2)μm(均為P0.05)。黃斑區(qū)各個扇形區(qū)域GCIPL厚度中,DR組的上方、鼻側(cè)和下方區(qū)域,以及NDR組的鼻下和下方區(qū)域明顯變薄,與對照組相比差異均有統(tǒng)計學(xué)意義(均為P0.05)。DR組和NDR組之間的GCIPL厚度相近,差異均無統(tǒng)計學(xué)意義(均為P0.05)。DR組、NDR組和對照組的黃斑區(qū)神經(jīng)纖維層厚度相近,差異均無統(tǒng)計學(xué)意義(均為P0.05)。結(jié)論糖尿病患者在DR出現(xiàn)之前就已經(jīng)出現(xiàn)了GCIPL的變薄,頻域OCT可被用于監(jiān)測糖尿病患者早期出現(xiàn)的視網(wǎng)膜神經(jīng)退行性改變。
[Abstract]:Objective to investigate the frequency-domain OCT (Cirrus HD-OCT (OCT (Cirrus HD-OCT) characteristics of retinal structural changes in diabetic macular area and compare the measured parameters with those of normal subjects. Methods the structural parameters of macular retina measured by Cirrus HDOCT in diabetic patients were analyzed retrospectively. Diabetic eyes were divided into diabetic retinopathy Dr group and non Dr group (NDR group), which included healthy controls matched with age and sex distribution of diabetic patients (control group), and macular nerve in three groups. The thickness of the fibrous layer was compared with the thickness of the ganglion cell-inner plexiform layer (GCIPL). Results 42 patients (42 eyes) with type 2 diabetes mellitus (Dr group, 26 eyes, 16 eyes of NDR group) and 30 healthy controls (30 eyes) were included in this study. The GCIPL of Dr group was (77.2 鹵8.7) 渭 m (79.4 鹵11.3) 渭 m, which was lower than that of control group (83.2 鹵7.6) 渭 m (P0.05). The minimum GCIPL of Dr group was (65.4 鹵9.3) 渭 m (69.7 鹵7.6) 渭 m, which was lower than that of control group (76.2 鹵9.2) 渭 m (P0.05). The thickness of GCIPL in each sector of macular area in Dr group was significantly thinner than that in control group (P0.05). The thickness of GCIPL between Dr group and NDR group was similar to that of Dr group, and the subnasal and inferior regions of NDR group were significantly thinner than that of control group. There was no significant difference (P0.05). The thickness of macular nerve fiber layer in Dr group was similar to that in control group (P0.05). Conclusion GCIPL thinned before Dr appeared in diabetic patients. Frequency domain OCT can be used to monitor retinal neurodegenerative changes in early diabetic patients.
【作者單位】： 中山大學(xué)中山眼科中心海南眼科醫(yī)院海南省眼科重點實驗室;
【基金】：海南省衛(wèi)生和計劃生育委員會普通醫(yī)學(xué)科研項目(編號:瓊衛(wèi)2014資助-055號)~~
【分類號】：R587.2;R774.1

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