【摘要】：研究目的:通過(guò)測(cè)定唾液酸(SA)在類(lèi)風(fēng)濕關(guān)節(jié)炎(RA)患者和健康對(duì)照組血清中水平并進(jìn)行對(duì)比,分析其與RA的實(shí)驗(yàn)室檢查結(jié)果及臨床表現(xiàn)之間的相關(guān)性,進(jìn)一步探討SA在RA發(fā)病機(jī)制中的作用及臨床意義。研究方法:共收集120例RA患者和60例健康對(duì)照者。用酶法測(cè)定兩組血清SA水平并比較;將RA患者血清SA與其紅細(xì)胞沉降率(ESR)、C反應(yīng)蛋白(CRP)、類(lèi)風(fēng)濕因子(RF)、抗環(huán)瓜氨酸肽抗體(抗CCP抗體)等檢查結(jié)果,以及病程、治療時(shí)間、關(guān)節(jié)腫脹計(jì)數(shù)(SJC)、關(guān)節(jié)疼痛計(jì)數(shù)(TJC)及疾病活動(dòng)度評(píng)分(DAS-28)進(jìn)行相關(guān)性分析。統(tǒng)計(jì)學(xué)分析采用t檢驗(yàn)、U檢驗(yàn)、卡方檢驗(yàn)及Pearson相關(guān)檢驗(yàn)。結(jié)果:1.RA患者的血清SA水平(864.05±167.70)明顯高于健康對(duì)照組(570.99±67.37),差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。2.RA患者血清SA水平與其CRP、ESR、RF、抗CCP抗體水平均呈正相關(guān),但只有與CRP和ESR的相關(guān)性具有統(tǒng)計(jì)學(xué)意義(r=0.53,P=0.00;r=0.52,P=0.00;r=0.06,P=0.55;r=0.01,P=0.89)。3.RA患者SA水平與年齡、TJC、SJC、DAS-28(CRP)、DAS-28(ESR)、Sharp評(píng)分均呈正相關(guān)(r=0.07,P=0.43;r=0.32,P=0.00;r=0.22,P=0.02;r=0.47,P=0.00;r=0.47,P=0.00;r=0.13,P=0.58),但只有與TJC、SJC、DAS-28(CRP)、DAS-28(ESR)的相關(guān)性具有統(tǒng)計(jì)學(xué)意義(P0.05);與病程、治療時(shí)間呈負(fù)相關(guān)性(r=-0.09,P=0.31;r=-0.06,P=0.51),差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。分析結(jié)果顯示:1.RA的疾病活動(dòng)度與血清SA水平有關(guān)。2.蛋白質(zhì)糖基化末端SA的缺失可能與RA的發(fā)病有關(guān)。3.免疫球蛋白糖鏈的SA缺失可能誘發(fā)自身免疫反應(yīng),導(dǎo)致滑膜炎癥從而致病。4.聯(lián)合應(yīng)用Ig G0、Siglec-1、RF及抗CCP抗體有助于RA的早期診斷和治療效果的評(píng)價(jià)。5.血清SA水平可作為監(jiān)測(cè)RA病情變化、指導(dǎo)治療的臨床指標(biāo)。
[Abstract]:Objective: to determine the serum levels of sialic acid (SA) in patients with rheumatoid arthritis (RA) and healthy controls, and to analyze the correlation between sialic acid (SA) and the laboratory results and clinical manifestations of RA. To further explore the role and clinical significance of SA in the pathogenesis of RA. Methods: 120 RA patients and 60 healthy controls were collected. Serum SA levels were measured by enzyme method in two groups, and the results of serum SA and erythrocyte sedimentation rate (ESR) / C reactive protein, (CRP), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP antibody), course of disease, treatment time, etc.) of RA patients were compared. Joint swelling count (SJC), joint pain count (TJC) and disease activity score (DAS-28) were analyzed. T test, chi-square test and Pearson correlation test were used in statistical analysis. Results the serum SA level in RA patients (864.05 鹵167.70) was significantly higher than that in healthy controls (570.99 鹵67.37). The difference was statistically significant (P0.05). 浣嗗彧鏈変笌CRP鍜孍SR鐨勭浉鍏蟲(chóng)，

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