本文選題：原發(fā)性舍格倫綜合征 + Th22�。� 參考：《佳木斯大學(xué)》2015年碩士論文

【摘要】：目的:探討原發(fā)性舍格倫綜合征pSS的發(fā)病機(jī)制。方法:本課題擬通過流式細(xì)胞儀檢測Th22在pSS患者和健康人外周血中的表達(dá)情況,并用ELISA檢測pSS患者和健康人血漿中IL-22的水平,同時(shí)觀察患者腺體破壞輕、中、重三種程度的pSS患者外周血中這些細(xì)胞亞群及其細(xì)胞因子的變化,從而探討Th22和IL-22在pSS發(fā)病中量的變化。結(jié)果:pSS患者外周血中的Th22細(xì)胞及其細(xì)胞因子的表達(dá)頻率明顯高于健康對(duì)照組,并且Th22及其細(xì)胞因子IL-22的表達(dá)量隨著病情的逐步加重而逐步增加。結(jié)論:針對(duì)Th22細(xì)胞活性調(diào)節(jié)及IL-22效應(yīng)通路進(jìn)行的干預(yù)很可能成為臨床治療原發(fā)性舍格倫綜合征的新靶點(diǎn)。
[Abstract]:Objective: to investigate the pathogenesis of PSS in patients with primary Schaeglen syndrome. Methods: the expression of Th22 in peripheral blood of PSS patients and healthy people was detected by flow cytometry, and the levels of IL-22 in plasma of PSS patients and healthy people were detected by Elisa. The changes of these cell subsets and their cytokines in peripheral blood of patients with severe PSS were studied to explore the changes of Th22 and IL-22 in the pathogenesis of PSS. Results the expression frequency of Th22 cells and their cytokines in patients with PSS was significantly higher than that in healthy controls, and the expression of Th22 and its cytokines IL-22 increased gradually with the exacerbation of the disease. Conclusion: the intervention of Th22 cell activity regulation and IL-22 effect pathway may be a new target for the clinical treatment of primary Schegren syndrome.
【學(xué)位授予單位】：佳木斯大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：R593.2

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本文編號(hào)：2109320