發(fā)布時(shí)間：2018-07-09 12:25

  本文選題：型糖尿病 + 脂代謝��； 參考：《中國老年學(xué)雜志》2016年15期

【摘要】：目的探討老年2型糖尿病患者脂代謝水平與認(rèn)知功能的相關(guān)性。方法隨機(jī)抽取老年2型糖尿病入院患者150例,按總膽固醇(TC)值分為A組(TC5.2 mmol/L)、B組(TC 5.2 mmol/L~5.7 mmol/L)、C組(TC5.7 mmol/L)各50例,入院時(shí)均應(yīng)用蒙特利爾認(rèn)知評估量表(Mo CA)及簡易精神狀態(tài)量表(MMSE)測試其認(rèn)知功能。結(jié)果 A組Mo CA因子分?jǐn)?shù)及總分高于B、C組(P0.05,P0.01);B組的命名、抽象思維及記憶延遲因子的分?jǐn)?shù)及總分明顯高于C組(P0.01);B組的視空間、注意、語言、定向力因子分?jǐn)?shù)高于C組(P0.05)。A組MMSE因子分?jǐn)?shù)及總分與B組比較無統(tǒng)計(jì)學(xué)差異(P0.05),但明顯高于C組(P0.01);B組的記憶力、回憶因子分?jǐn)?shù)及總分明顯高于C組(P0.01),而定向力、注意力及計(jì)算力、語言因子分?jǐn)?shù)及總分分?jǐn)?shù)高于C組(P0.05)。結(jié)論 TC、高密度脂蛋白膽固醇(HDL-C)、載脂蛋白(Apo)A-I值越高,認(rèn)知功能越好;甘油三酯(TG)、低密度脂蛋白膽固醇(LDL-C)、ApoB-100及脂蛋白a(Lpa)值越高,認(rèn)知功能越差;極LDL-C(VLDL-C)值與認(rèn)知功能無關(guān)。
[Abstract]:Objective to investigate the correlation between lipid metabolism and cognitive function in elderly type 2 diabetes mellitus. Methods 150 elderly patients with type 2 diabetes mellitus were randomly divided into two groups: group A (TC5.2 mmol / L), group B (TC 5.2 mmol / L) and group C (TC5.7 mmol / L). The cognitive function was measured by the Montreal Cognitive Assessment scale (MOCA) and the Mini-Mental State scale (MMSE) on admission. Results the scores and total scores of Mo CA factor in group A were higher than those in group B (P0.05 / P0.01). The scores and total scores of abstract thinking and memory retardation in group A were significantly higher than those in group C (P0.01). The score of directional force factor was higher than that of group C (P0.05). The score and total score of MMSE in group A were not significantly different from those in group B (P0.05), but significantly higher than those in group C (P0.01). The scores of recall factor and total score in group A were significantly higher than those in group C (P0.01), while the ability of orientation, attention and calculation were significantly higher than those in group C (P0.01). Language factor score and total score were higher than C group (P0.05). Conclusion High density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A-I and triglyceride (TG), low density lipoprotein cholesterol (LDL-C), ApoB-100 and lipoprotein a (LPA) are associated with lower cognitive function, while very low density lipoprotein cholesterol (VLDL-C) is not associated with cognitive function.
【作者單位】： 武漢市中心醫(yī)院心內(nèi)科;
【分類號】：R587.1

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