發(fā)布時(shí)間：2018-07-04 17:22

  本文選題：型糖尿病 + 胰島素受體底物��； 參考：《重慶醫(yī)科大學(xué)學(xué)報(bào)》2016年11期

【摘要】：目的:探究胰島素受體底物2(insulin receptor substrate 2,IRS2)基因單核苷酸多態(tài)性位點(diǎn)Gly1057Asp與環(huán)境間的交互作用對(duì)2型糖尿病(type 2 diabetes mellitus,T2DM)易感性的影響。方法:對(duì)772例無血緣關(guān)系的中國重慶漢族人(T2DM 467例,健康對(duì)照305例)進(jìn)行病例-對(duì)照研究。應(yīng)用限制性片段長度多態(tài)性聚合酶鏈反應(yīng)聯(lián)合基因測序法檢測IRS2基因Gly1057Asp位點(diǎn)基因型,分析其與T2DM的相關(guān)性。采用多因子降維法(multifactor dimensionality reduction,MDR)分析Gly1057Asp位點(diǎn)與老齡、肥胖及高甘油三酯血癥間的交互作用對(duì)T2DM易感性的影響。結(jié)果:IRS2基因Gly1057Asp位點(diǎn)與T2DM相關(guān),GG基因型個(gè)體T2DM患病風(fēng)險(xiǎn)是AA基因型的1.42倍(OR=1.422,95%CI=1.037~1.949,P=0.029)。MDR分析顯示Gly1057Asp位點(diǎn)、年齡、腰圍和血漿三酰甘油四個(gè)因素構(gòu)成的交互模型具有統(tǒng)計(jì)學(xué)意義(P=0.001)。在老齡(年齡60歲)或腹型肥胖者中,Gly1057Asp位點(diǎn)GG或GA基因型個(gè)體T2DM患病風(fēng)險(xiǎn)明顯增加;在腹型肥胖的高甘油三酯血癥者中,除年齡在40~60歲且具AA基因型者外,其余均易患T2DM(OR=3.342,95%CI=1.168~9.561,P=0.026)。結(jié)論:同時(shí)具有IRS2基因Gly1057Asp位點(diǎn)GG基因型、腹型肥胖和高甘油三酯血癥的中國重慶漢族人,可能是T2DM的高危易感人群。
[Abstract]:Objective: To investigate the effect of the interaction between the single nucleotide polymorphism site (Gly1057Asp) of the insulin receptor substrate 2 (insulin receptor substrate 2, IRS2) gene and the environment on type 2 diabetes mellitus (type 2 diabetes mellitus, T2DM) susceptibility. Methods: 772 cases of Chongqing Han people in China (T2DM 467 cases, 305 healthy controls) were carried out. Case control study. The restriction fragment length polymorphism polymerase chain reaction (PCR) combined gene sequencing was used to detect the genotype of IRS2 gene Gly1057Asp, and the correlation with T2DM was analyzed. The multiple factor dimensionality reduction (multifactor dimensionality reduction, MDR) was used to analyze the Gly1057Asp locus with aging, obesity and hypertriglyceridemia. The effect of interaction on T2DM susceptibility. Results: the Gly1057Asp locus of the IRS2 gene is associated with T2DM. The risk of T2DM disease in the GG genotype is 1.42 times the AA genotype (OR=1.422,95%CI=1.037~1.949, P=0.029).MDR analysis shows the Gly1057Asp site, age, waist circumference and plasma three glycerol four factors have statistical meaning. Meaning (P=0.001). Among the elderly (age 60) or abdominal obesity, the risk of T2DM in the Gly1057Asp locus GG or GA genotype individuals increased significantly; among those with high triglyceride in abdominal obesity, the rest were susceptible to T2DM (OR= 3.342,95%CI=1.168~9.561, P=0.026) except for the age of 40~60 and the AA genotypes. Gly1057Asp locus GG genotype, abdominal obesity and hypertriglyceridemia in Han Chinese in Chongqing, China, may be a high-risk susceptible group of T2DM.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院內(nèi)分泌科;重慶醫(yī)科大學(xué)感染性疾病分子生物學(xué)教育部重點(diǎn)實(shí)驗(yàn)室;吉首大學(xué)醫(yī)學(xué)院藥理教研室與疾病基因研究室;
【基金】：國家臨床重點(diǎn)�？平ㄔO(shè)資助項(xiàng)目(編號(hào):財(cái)社[2011]170號(hào)) 重慶市衛(wèi)生局中醫(yī)藥科技課題資助項(xiàng)目(編號(hào):2010-2-134)
【分類號(hào)】：R587.1

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